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CAS No. : | 626-60-8 | MDL No. : | MFCD00006375 |
Formula : | C5H4ClN | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | PWRBCZZQRRPXAB-UHFFFAOYSA-N |
M.W : | 113.55 | Pubchem ID : | 12287 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P210-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P370+P378-P362+P364-P403+P233-P501 | UN#: | |
Hazard Statements: | H227-H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.5 g | Stage #1: With lithium diisopropyl amide In tetrahydrofuran at -75℃; for 4 h; Stage #2: With iodine In tetrahydrofuran at -75℃; for 1 h; |
To a cold solution of 3-chloro pyridine (1.0 g, 8.88 mmol) in THF (30.0 mL) was added LDA (5.9 mL, 8.88 mmol) at -75°C. The reaction mixture was stirred at -75°C for 4 h. Iodine (2.2 g, 8.88 mmol) was added and continued stirring at -75°C for 1 h. The reaction mixture was quenched in water at -70°C, extracted with ethyl acetate and concentrated to afford 0.500 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 8.01 (d, J = 5.1 Hz, 1H), 8.14 (d, / = 4.8 Hz, 1H), 8.63 (s, 1H). |