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Chemical Structure| 6277-18-5 Chemical Structure| 6277-18-5

Structure of 6277-18-5

Chemical Structure| 6277-18-5

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Product Details of [ 6277-18-5 ]

CAS No. :6277-18-5
Formula : C4H2INO2S
M.W : 255.03
SMILES Code : O=[N+](C1=CC=C(I)S1)[O-]

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Application In Synthesis of [ 6277-18-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6277-18-5 ]

[ 6277-18-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6277-18-5 ]
  • [ 20358-03-6 ]
  • 5-bromo-N,N-bis(5-nitrothiophen-2-yl)benzo[d]thiazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With cesium fluoride; In dimethyl sulfoxide; at 150℃; for 24h;Inert atmosphere; 2.291 g (0.01 mol) of <strong>[20358-03-6]2-amino-5-bromobenzothiazole</strong> and 12.752 mg (0.05 mol)2-iodo-5-nitrothiophene was added to a 250 mL three-necked flask with DMSO as solvent.Magnetically stirred and argon gas, the oil bath was heated to 150 ° C, and then added 3.038 g (0.02 mol) of cesium fluoride (CsF), reflux reaction for 24 h.The reaction solution was poured into ice water, extracted with dichloromethane, and the solvent was evaporated to -101.The product was purified by column chromatography using ethyl acetate: petroleum ether = 1:10 (volume ratio) as mobile phase and silica gel as stationary phase.The product was collected, dried and dried in vacuo at 80 ° C for 24 h.The product was obtained 3.142 g in 65percent yield.
 

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