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Chemical Structure| 629-76-5 Chemical Structure| 629-76-5
Chemical Structure| 629-76-5

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1-Pentadecanol is a natural product with anti-acne activity and can also serve as a starting material for asymmetric synthesis.

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Product Details of 1-Pentadecanol

CAS No. :629-76-5
Formula : C15H32O
M.W : 228.41
SMILES Code : CCCCCCCCCCCCCCCO
MDL No. :MFCD00004759
InChI Key :REIUXOLGHVXAEO-UHFFFAOYSA-N
Pubchem ID :12397

Safety of 1-Pentadecanol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 1-Pentadecanol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 629-76-5 ]

[ 629-76-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 629-76-5 ]
  • [ 3543-75-7 ]
  • [ 1609623-06-4 ]
YieldReaction ConditionsOperation in experiment
With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20℃;Inert atmosphere; Preparation of 4-{5-[Bis-(chloroethyl)-amino]-l-methyl-lH-benzimidazol-2-yl}butyric acid pentadecyl ester (<strong>[3543-75-7]bendamustine</strong> Ci ester): A 250 mL three neck round bottom flask was equipped with an overhead stirrer, thermocouple, temperature controller and nitrogen sweep then charged with 10.0 g (25.34 mmol) of <strong>[3543-75-7]<strong>[3543-75-7]bendamustine</strong> hydrochloride</strong>, 5.85 g (25.6 mmol, 1.01 eq) of pentadecanol, 5.3 g (25.6 mmol, 1.01 eq) of dicyclohexylcarbodiimide (DCC), 100 mL of MDC and 0.31 g (2.54 mmol, 0.1 eq) of DMAP. The reaction was stirred at room temperature overnight at which time an in process analysis indicated the reaction was complete. Solids were removed by vacuum filtration and washed with 25 mL of MDC. The filtrate was washed with saturated aqueous sodium bicarbonate solution (2 X 100 mL), DI water (1 X 100 mL) and brine (1 X 100 mL) before drying over sodium sulfate, filtering and concentrating to dryness in vacuo to an off-white solid. This solid was triturated with 25 mL of MDC and the solid impurities were removed by vacuum filtration and washed with 5 mL of MDC. The filtrate was concentrated to dryness in vacuo to yield 10.8 g (19.0 mmol, 75%) of the product as an off-white solid with an HPLC purity of 94.6A%. NMR (400 MHz, CDC13) delta 7.17 (d, J= 8.76 Hz, 1H), 7.08 (d, J= 2.32 Hz, 1H), 6.78 (dd, J= 2.4, 8.76 Hz, 1H), 4.05 (t, J= 6.8 Hz, 2 H), 3.72 (m, 4H), 3.69 (s, 3H), 3.63 (m, 4H), 2.91 (t, J= 7.4 Hz, 2H), 2.49 (t, J= 7.08 Hz, 2H), 2.18 (m, 2H), 1.60 (m, 2H), 1.32 (m, 24H), 0.88 (t, J= 6.68 Hz, 3H).
 

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