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Chemical Structure| 63-89-8 Chemical Structure| 63-89-8
Chemical Structure| 63-89-8

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Colfosceril palmitate is a drug used as a pulmonary surfactant. It is also a key conponent of LNP as an effective delivery vehicle of mRNA.

Synonyms: 129Y83; 1,2-Dipalmitoyl-sn-glycero-3-phosphorylcholine; 1,2-Dipalmitoyl-sn-glycero-3-PC

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Product Citations

Product Citations

Liu, Yichen ; Kim, Gaeun ; Zhu, Runyao ; Jeon, Hyunsu ; Wang, Yichun ;

Abstract: Tumor hypoxia and poor penetration of therapeutics across tumor-microenvironment barriers remain major obstacles to effective cancer therapy, including photodynamic therapy (PDT). Here we introduce a nanochirality-programmed assembly (L-Chi-GAIN) in which nanochirality drives site-selective assembly that activates oxygen-independent Type-I reactive oxygen species (ROS) generation and reduces hyaluronan-mediated matrix adhesion, thereby permitting deep intratumoral therapy. Glycosylation imparts structural chirality to graphene quantum dots (GQDs), directing site-selective assembly of indocyanine green (ICG) that turns on photoinduced electron transfer (PET), producing a 64-fold increase in ROS relative to free ICG. Nanochirality also modulates assembly–extracellular matrix (ECM) interactions. L-GQDs show a less favorable hyaluronan binding free energy (ΔGbind), thus accelerating interstitial transport and resulting in ∼21-fold deeper tumor penetration by L-Chi-GAIN than conventional nanocarriers. Under near-infrared irradiation, L-Chi-GAIN elicits strong oxidative stress and triggers Gasdermin-D (GSDMD)-dependent pyroptosis, leading to significant suppression of tumor growth. This work offers a nanochirality-guided design strategy for PDT in deep tumors by coupling site-selective assembly with stereoselective navigation of the ECM.

Keywords: Graphene quantum dot ; Solid tumor ; Type-I reactive oxygen species ; Chirality ; Extracellular matrix

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Product Details of DPPC

CAS No. :63-89-8
Formula : C40H80NO8P
M.W : 734.04
SMILES Code : O=P(OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)([O-])OCC[N+](C)(C)C
Synonyms :
129Y83; 1,2-Dipalmitoyl-sn-glycero-3-phosphorylcholine; 1,2-Dipalmitoyl-sn-glycero-3-PC
MDL No. :MFCD00036903
InChI Key :KILNVBDSWZSGLL-KXQOOQHDSA-N
Pubchem ID :452110

Safety of DPPC

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of DPPC

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63-89-8 ]

[ 63-89-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 63-89-8 ]
  • [ 61-73-4 ]
  • C40H80NO8P*C34H24N6O14S4(4-)*4Na(1+) [ No CAS ]
  • 2
  • [ 63-89-8 ]
  • [ 57-09-0 ]
  • [ 61-73-4 ]
  • 2C19H42N(1+)*2Br(1-)*C34H24N6O14S4(4-)*4Na(1+)*2C40H80NO8P [ No CAS ]
  • 3
  • [ 63-89-8 ]
  • [ 57-09-0 ]
  • [ 61-73-4 ]
  • C19H42N(1+)*Br(1-)*C40H80NO8P*C34H24N6O14S4(4-)*4Na(1+) [ No CAS ]
  • 4
  • [ 63-89-8 ]
  • [ 57-09-0 ]
  • [ 61-73-4 ]
  • 3C19H42N(1+)*3Br(1-)*3C40H80NO8P*C34H24N6O14S4(4-)*4Na(1+) [ No CAS ]
 

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