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Chemical Structure| 63197-24-0 Chemical Structure| 63197-24-0

Structure of 63197-24-0

Chemical Structure| 63197-24-0

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Product Details of [ 63197-24-0 ]

CAS No. :63197-24-0
Formula : C15H11NO3
M.W : 253.25
SMILES Code : O=C1N(C)C(C2=C1C=CC(OC3=CC=CC=C3)=C2)=O

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Application In Synthesis of [ 63197-24-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63197-24-0 ]

[ 63197-24-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 63197-24-0 ]
  • [ 57830-14-5 ]
YieldReaction ConditionsOperation in experiment
85% In a stirred three-necked flask equipped with 40 g of sodium hydroxide, Add 200 mL of water to dissolve and cool to 0-5 C. Then, 100 g of the intermediate N, methyl-4-phenoxy-phthalimide prepared in the previous step was fed in batches, About 1h cast, 0-5 insulation 1-2h. Thin layer chromatography to the disappearance of raw materials after adding 130g zinc powder and 200mL water, heated to 90 , Insulation reaction 5h, After the end of insulation to room temperature, The filter cake was washed with 50 ml * 2. The filtrate and hydrochloric acid adjusted PH = 1, the temperature to 80 , Insulation 1-2h, after the end of insulation to room temperature, With 30% sodium hydroxide to adjust the pH to 5-7, filter, filter cake washed with water, After drying, add to 150mL methanol at room temperature for half an hour, filter, The filter cake was washed with methanol 30 mL * 2 and the product was removed by drying to give 75 g of product, 85% yield and 99% purity.
  • 2
  • [ 63197-24-0 ]
  • [ 57830-14-5 ]
  • 6-phenoxy-1(3H)-isobenzofuranone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Sodium hydroxide (4.0 g, 0.1 mol), water (45.6 g), zinc powder (23.5 g, 0.36 mol), and 4-phenoxy-N-methyl phthalimide (Formula VHIb, 22.8 g, 0.09 mol) are mixed and heated at reflux for 6 hours. The reaction mixture is cooled to 60C. Toluene (45.6 g) is added, and followed by adding 36% hydrochloric acid (145.8 g). The reaction mixture is heated at reflux for 8 hours, during which zinc powder is dissolved completely. Organic layer is separated and washed with water twice (22.8 g each) after the reaction mixture was cooled to 60C, then concentrated to give the crude mixture of 5- phenoxy-l(3H)-isobenzofuranone of Formula I and 6-phenoxy-l(3H)-isobenzofuranone of Formula Ia (18.3 g, the isomer ratio = 83: 17, the crude yield: 90%.)
 

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