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Chemical Structure| 641615-34-1 Chemical Structure| 641615-34-1

Structure of 641615-34-1

Chemical Structure| 641615-34-1

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Product Details of [ 641615-34-1 ]

CAS No. :641615-34-1
Formula : C9H11N3O
M.W : 177.20
SMILES Code : CN(C)\C=C\C(=O)C1=CN=CN=C1
MDL No. :MFCD09836136

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Application In Synthesis of [ 641615-34-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 641615-34-1 ]

[ 641615-34-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 641615-34-1 ]
  • [ 64513-70-8 ]
  • N-[2-oxo-6-(5-pyrimidyl)pyran-3-yl]cyclopropanecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
8% With acetic anhydride; at 90℃; for 6h; acetic anhydride (2.70 mL, 28.56 mmol) was added to a mixture of 1-(5-pyrimidyl)-3-(dimethylamino)-2-propene-1-one (385 mg, 2.20 mmol) and <strong>[64513-70-8]2-(cyclopropanecarboxamido)acetic acid</strong> (314 mg, 2.20) and the mixture was heated at 90 C. for 6 hours, after which time TLC showed complete consumption of the starting material. The volatiles were removed in vacuo before the crude material was purified by flash chromatography on silica gel (solvent EtOAc) to afford the title compound as a yellow solid (47 mg, 8%). 1H NMR deltaH (DMSO-d6, 300 MHz): 10.12 (br, 1H), 9.32 (s, 1H), 9.20 (s, 2H), 8.26 (d, J=8.0 Hz, 1H), 7.33 (d, J=8.0 Hz, 1H), 2.31 (br, 1H), 0.84-0.82 (m, 4H) ppm. ESI-MS 258.0 [MH]+.
 

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