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Chemical Structure| 641615-38-5 Chemical Structure| 641615-38-5

Structure of 641615-38-5

Chemical Structure| 641615-38-5

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Product Details of [ 641615-38-5 ]

CAS No. :641615-38-5
Formula : C15H14N6
M.W : 278.31
SMILES Code : NC1=CC=C(C)C(NC2=NC=CC(C3=NC=CN=C3)=N2)=C1

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Application In Synthesis of [ 641615-38-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 641615-38-5 ]

[ 641615-38-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 641615-38-5 ]
  • [ 161622-05-5 ]
  • [ 812700-17-7 ]
YieldReaction ConditionsOperation in experiment
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; A mixture of 4-Methyl-N*3*- (4-pyrazin-2-yl-pyrimidin-2-yl)-benzene-1, 3-diamine (0.55 g, 1.98 MMOL), 3-Fluoro-5-trifluoromethyl-benzoic acid (0.43 g, 2.08 MMOL), BOP (1.05 g, 2.38 MMOL) and DIEA (1.25 mL, 7.20 MMOL) is stirred in 9.0 mL of DMF at room temperature overnight. 25 mL of water is added to the precipitate. The resulting suspension is allowed to stir at room temperature for one hour. It is then filtered through a Buchner funnel, air dried and triturated with 10.0 mL of CH30H for 1 hour and dried. 0.80 g of 3-FLUORO-N- [4-METHYL-3- (4-PYRAZIN-2- yl-pyrimidin-2-ylamino)-phenyl]-5-trifluoromethyl-benzamide is obtained as a pale yellow solid. RH NMR (DMSO, 500MHZ) : No. (ppm) 10.49 (s, 1H), 9.49 (s, 1H), 9.10 (s, 1H), 8.79 (s, 2H), 8. 62 (d, 2H, J=4.81 Hz), 8.10-8. 20 (m, 3H), 7.96 (d, 1H, J=8.66Hz), 7. 63 (d, 1H, J=4. 78Hz), 7.48 (dd, 1H, J1=8. 46Hz, J2=2. 05 HZ), 7.26 (d, 1H, J=8.09Hz), 2.26 (s, 3H). API-MS m/z 469.1 ([M+H] +, CALCD 469.1)
 

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