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Chemical Structure| 650578-82-8 Chemical Structure| 650578-82-8

Structure of 650578-82-8

Chemical Structure| 650578-82-8

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Product Details of [ 650578-82-8 ]

CAS No. :650578-82-8
Formula : C6H6Cl2FN
M.W : 182.02
SMILES Code : NC1=CC=CC(Cl)=C1F.[H]Cl

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Application In Synthesis of [ 650578-82-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 650578-82-8 ]

[ 650578-82-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 650578-82-8 ]
  • [ 517920-75-1 ]
YieldReaction ConditionsOperation in experiment
Example 15 7-Chloro-6-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride Step A.; A solution of sodium nitrite (12.5 g, 85.9 mmol) and H2O (21.4 mL) was added dropwise at 0 C. to a solution of 3-chloro-2-fluorobenzenamine hydrochloride (2.0 g, 8.45 mmol) in 12N HCl (203.3 mL) and TFA (23.4 mL). The reaction mixture was stirred at 0 C. for 1 h followed by the dropwise addition of a solution of tin(II)chloride (35.8 g, 188.9 mmol) in 12N HCl (51.6 mL) and H2O (6.8 mL) at 0 C. The reaction mixture stirred for 15 h at 20 C. and was filtered and placed under vacuum to give 1-(3-chloro-2-fluorophenyl)hydrazine hydrochloride as a gold solid (23.5 g, 119.0 mmol).
 

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