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Chemical Structure| 651728-72-2 Chemical Structure| 651728-72-2

Structure of 651728-72-2

Chemical Structure| 651728-72-2

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Product Details of [ 651728-72-2 ]

CAS No. :651728-72-2
Formula : C16H15ClO6S2
M.W : 402.87
SMILES Code : O=C(OCCS(=O)(C1=CC=C(C)C(S(=O)(Cl)=O)=C1)=O)C2=CC=CC=C2

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Application In Synthesis of [ 651728-72-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 651728-72-2 ]

[ 651728-72-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 651728-72-2 ]
  • [ 117976-90-6 ]
  • 3-{2-[4-(3-methoxypropoxy)-3-methylpyridin-2-yl-methanesulfinyl]benzimidazole-1-sulfon-yl}benzoic acid 2-(toluene-4-sulfonyl)ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With sodium hydrogencarbonate; triethylamine; In dichloromethane; at 20℃; for 1.5h; To a solution [OF 2- [4- (3-METHOXY-PROPOXY)-3-METHYL-PYRIDIN-2-YL-] [METHANESULFINYL]-LH-BENZIMIDAZOLE] sodium salt (RABEPRAZOLE sodium salt, 1.0 g, 2.62 mmol), 5 mL [OF ET3N,] and about 1 g of NaHCO3 in [CH2CL2] (15 mL) was added the sulfonyl chloride (Intermediate 43,1. 27 g, 3.15 mmol, 1.2 eq) in [CH2C12] at room temperature, and then the mixture was stirred for 1.5 h. Thereafter water was added, the mixture was extracted with [CH2CL2,] and the organic layers were dried, and concentrated. The resulting residual oil was purified by column chromatography [(CH2CL2] [1% MEOH INCH2CL2)] to yield 1.5 g (76%) [OF 3-F2- [4- (3-METHOXY-PROPOXY)-3-METHYL-PYRIDIN-2-YL-] [METHANESULFINYL]-BENZIMIDAZOLE-L-SULFONYL}] benzoic acid [2- (TOLUENE-4-] sulfonyl) ethyl ester (Intermediate 48) as an off-white foam. 'H NMR (CDC13, 400 MHz) [T52.] 09 (m, 2 H), 2.24 (s, 3 H), 2.29 (s, 3 H), 3.34 (s, [3 H),] 3.57 (m, 4 H), 4.13 (t, 2 H), 4.65 (m, 2 H), 5.05 (dd, [2 H),] 6.75 (d, [1] H), 7.20 (d, 2 H), 7.41 (t, [1] H), 7.50 (t, [1] H), 7.58 (t, 1 [H), 7.] 77 [(M,] 3 H), 8.01 (t, 2 H), 8.19 (d, [1] H), 8.37 (d, [1] H), 8.60 (s, [1] H).
 

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