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Chemical Structure| 65202-53-1 Chemical Structure| 65202-53-1

Structure of 65202-53-1

Chemical Structure| 65202-53-1

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Product Details of [ 65202-53-1 ]

CAS No. :65202-53-1
Formula : C4H3IN2
M.W : 205.98
SMILES Code : IC1=NN=CC=C1
MDL No. :MFCD18412802

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Application In Synthesis of [ 65202-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65202-53-1 ]

[ 65202-53-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1120-95-2 ]
  • [ 65202-53-1 ]
YieldReaction ConditionsOperation in experiment
55% Preparation 119: 3-lodo-pyridazine (Prep119); A mixture of <strong>[1120-95-2]3-chloro-pyridazine</strong> (Prep118, 2.1 g, 18.4 mmol) and NaI, (4 g, 26.8 mmol) in57percent Hlaq (16 ml) was warmed at 50°C for 24 hours. After cooling the solution was basified with solid NaHCO3 and extracted with ethyl acetate. The organic phase was dried <n="125"/>(Na2SO4) and evaporated to give 2.1 g of the title compound as a light brown powder(55percent yield).MS (ES) (mlz): 207.2 [M+H]+.
  • 2
  • [ 65202-53-1 ]
  • [ 189178-09-4 ]
  • C36H21N7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); copper (I) iodide; triethylamine; In tetrahydrofuran; at 40℃; for 48h;Inert atmosphere; General procedure: Tris(4-ethynylphenyl)amine 7 (0.25 mmol) and correspondinghalogenated diazine 4ab or 5ac or 6 (1 mmol) were dissolved in dryTHF (10 ml) and Et3N (2.5 ml). Argon was bubbled through the solutionfor 10 min, whereupon [PdCl2(PPh3)2] (16 mg, 0.09 eq.) and CuI (4 mg,0.09 eq.) were added. The reaction mixture was stirred under argonatmosphere at 40 .C for 48 h. The solvents were evaporated in vacuo andthe residue was taken up in aq. NH4Cl (50 ml) and was extracted withCH2Cl2 (2 × 50 ml). The combined organic extracts were dried (Na2SO4)×and the solvents were evaporated in vacuo. The crude product was purifiedby column chromatography.
 

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