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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 655-12-9 Chemical Structure| 655-12-9

Structure of 655-12-9

Chemical Structure| 655-12-9

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Product Details of [ 655-12-9 ]

CAS No. :655-12-9
Formula : C8H5ClF2O
M.W : 190.57
SMILES Code : CC(C1=CC(F)=C(Cl)C=C1F)=O
MDL No. :MFCD00068247

Safety of [ 655-12-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 655-12-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 655-12-9 ]

[ 655-12-9 ] Synthesis Path-Downstream   1~1

  • 1
  • potassium hypochlorite [ No CAS ]
  • [ 655-12-9 ]
  • [ 132794-07-1 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; potassium hydroxide; In water; EXAMPLE 1 Preparation of 4-Chloro-2,5-difluorobenzoic Acid A 3.6 liter aqueous solution containing 500 g (5.5 mole) of potassium hypochlorite and 115 g potassium hydroxide, was taken in a 5 liter, 3-necked round-bottomed flask equipped with a Trubore stirrer, a thermometer, an addition funnel and a water condenser. 228.5 g (1.2 mole) of 4'-chloro-2',5'-difluoroacetophenone was dissolved in 550 ml of chloride and the solution was slowly added to the flask via the addition funnel. The temperature was not allowed to exceed 40 C. After the addition was complete, the heterogeneous mixture was stirred vigorously at reflux (40 C.) for 18 hours. The reaction mixture was cooled to room temperature and filtered. The solid was dried and then suspended in 2200 ml of water containing 120 ml of concentrated HCl. It was stirred, filtered, washed with water, and dried in an oven to a constant weight of 177 g. It had a melting point of 154.7 C. The CH2 Cl2 layer was rotovapped to recover 30 g (13%) of the starting ketone, 4'-chloro-2',5'-difluoroacetophenone. The conversion of the ketone into acid was 87%. The yield of 4-chloro-2,5-difluorobenzoic acid was 88%.
 

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