Home Cart Sign in  
Chemical Structure| 65527-54-0 Chemical Structure| 65527-54-0

Structure of 65527-54-0

Chemical Structure| 65527-54-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 65527-54-0 ]

CAS No. :65527-54-0
Formula : C5H9NO2S
M.W : 147.20
SMILES Code : [H][C@]1(CSCCN1)C(O)=O
MDL No. :MFCD01318713

Safety of [ 65527-54-0 ]

Application In Synthesis of [ 65527-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65527-54-0 ]

[ 65527-54-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59237-53-5 ]
  • [ 65527-54-0 ]
  • [ 1236119-13-3 ]
YieldReaction ConditionsOperation in experiment
52% To a suspension of (R)-thiomorpholine-3-carboxylic acid (1.009 g, 6.86 mmol) in THF was added <strong>[59237-53-5]methyl 6-chloro-5-nitronicotinate</strong> (1.35 g, 6.23 mmol) and potassium carbonate (2.58 g, 18.70 mmol). The suspension was heated to reflux for 3 hours. The crude orange solution was allowed to cool to RT and filtered through a pad of celite which was washed with DCM (50 mL), and transferred to a bomb hydroginator. To the solution was added triphenyl phosphite (0.019 ml, 0.061 mmol), platinum (0.238 g, 0.061 mmol), and ammonium metavanadate. The vessel was sealed and pressurized to 140 psi with stirring for 24 h at room temperature. The vessel was depressurized and the mixture was diluted with DCM (100 mL) and refluxed for 30 minutes. The hot mixture was filtered through celite and concentrated to yield 887 mg (52percent) of the product as a white solid. [M+H] calc'd for C12H13N3O3S, 280; found, 280.
 

Historical Records

Technical Information

Categories