65548-54-1|7,8-Dimethoxy-2-phenyl-4H-chromen-4-one| Ambeed

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CAS No. :	65548-54-1
Formula :	C₁₇H₁₄O₄
M.W :	282.29
SMILES Code :	O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC(OC)=C3OC

Yield	Reaction Conditions	Operation in experiment
94%	With potassium hydroxide; In N,N-dimethyl-formamide; at 20℃; for 2h;	To a solution of <strong>[38183-03-8]7,8-dihydroxy-2-phenyl-4H-chromen-4-one</strong> (<strong>[38183-03-8]7,8-dihydroxyflavone</strong>, 1a) (254 mg, 1 mmol) in DMF (5.0 mL) was added methyl iodide (0.25 mL, 4 mmol, 4 equiv) and K2CO3 (1.11 g, 8 mmol, 8equiv). The reaction mixture was stirred at room temperature for 2 h. DMF was evaporated in vacuo and water (30 mL) was added to the crude mixture followed by extraction with ethyl acetate (3 × 30mL). The combined organic phases were washed with brine and dried over Na2SO4 and concentrated in vacuo. The title compound was obtained after recrystallization from ethyl acetate as greenish needles (264 mg, 94%). Rf=0.65 (2% MeOH/CH2Cl2).
	With potassium carbonate; In acetone; at 60℃;	General procedure: Methyl iodide (25 mmol, 5 eq) was added to a solution of potassium carbonate (30 mmol, 6 eq) and flavones (5mmol, 1.0 equal) or isoflavones (5 mmol, 1.0 equal) in acetone (60 mL). The reaction mixture was stirred overnight at 60C, and the solvent was then evaporated in vacuum. The residue was purified by silica gel column chromatography, eluting with a solution of 15% MeOH in dichloromethane (Scheme S2), to yield yellow solid 15-19

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H200	Unstable explosive
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 65548-54-1

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CAS No.: 65548-54-1

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[ 65548-54-1 ] Synthesis Path-Downstream 1~5

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