[ CAS No. 66086-33-7 ]

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Quality Control of [ 66086-33-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 66086-33-7 ]

SDS Specification

Alternatived Products of [ 66086-33-7 ]

Product Details of [ 66086-33-7 ]

CAS No. :	66086-33-7	MDL No. :	MFCD00008808
Formula :	C₁₂H₁₈O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FBCRUXRGQFLOMC-UHFFFAOYSA-N
M.W :	226.27	Pubchem ID :	545317
Synonyms :

Safety of [ 66086-33-7 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P261-P280-P305+P351+P338-P310	UN#:	3261
Hazard Statements:	H314-H335	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 66086-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 66086-33-7 ]
Downstream synthetic route of [ 66086-33-7 ]

[ 66086-33-7 ] Synthesis Path-Upstream 1~3

1
[ 66086-33-7 ]
[ 18305-60-7 ]

Reference： [1] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3834 - 3837

2
[ 66086-33-7 ]
[ 7633-38-7 ]
[ 18305-60-7 ]

Reference： [1] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3834 - 3837

3
[ 66086-33-7 ]
[ 30448-43-2 ]

Reference： [1] Chemische Berichte, 1980, vol. 113, # 2, p. 531 - 541

[ 66086-33-7 ] Synthesis Path-Downstream 1~68

1
[ 66086-33-7 ]
[ 5077-67-8 ]
[ 137579-09-0 ]

Reference： [1]Tetrahedron Letters,1991,vol. 32,p. 4687 - 4690

2
[ 66086-33-7 ]
[ 7387-57-7 ]
3-<2',3',5'-tri-O-acetyl-(β-D-ribofuranosyl)>-7H-7-oxo-9-t-butoxycarbonylpyrimido<2,1-i>purine [ No CAS ]

Reference： [1]Heterocycles,1995,vol. 41,p. 1197 - 1206

3
[ 66086-33-7 ]
[ 7473-98-5 ]
5,5-Dimethyl-4-phenyl-2,5-dihydro-furan-2,3-dicarboxylic acid di-tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With triphenylphosphine In dichloromethane for 24h; Ambient temperature;

Reference： [1]Yavari, Issa; Mosslemin, Mohammad Hossein [Tetrahedron, 1998, vol. 54, # 31, p. 9169 - 9174]

4
[ 66086-33-7 ]
[ 5077-67-8 ]
4-Ethyl-2,5-dihydro-furan-2,3-dicarboxylic acid di-tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron,1998,vol. 54,p. 9169 - 9174

5
[ 66086-33-7 ]
[ 80-71-7 ]
di-tert-butyl (E)-2-(2-methyl-5-oxo-1-cyclopentenyl)-2-butenodioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
36%	With triphenylphosphine In dichloromethane at -10 - 20℃; for 6h;

Reference： [1]Ramazani, Ali; Mohammadi, Bagher; Noshiranzadeh, Nader [Phosphorus, Sulfur and Silicon and the Related Elements, 2003, vol. 178, # 4, p. 767 - 771]

6
[ 354-38-1 ]
[ 66086-33-7 ]
[ 603-35-0 ]
C₃₂H₃₅F₃NO₅P [ No CAS ]
C₃₂H₃₅F₃NO₅P [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2003,vol. 178,p. 2183 - 2187

7
[ 66086-33-7 ]
[ 893-33-4 ]
di-tert-butyl 4-(2-naphthoyl)-3-trifluoromethyl-cyclobut-2-ene-1,2-dicarboxylate [ No CAS ]

Reference： [1]Synthesis,2004,p. 1029 - 1032

8
[ 66086-33-7 ]
[ 69065-98-1 ]
di-tert-butyl 4-ethoxy-1-(2-fluorophenyl)-5-oxo-2,5-dihydro-1H-pyrrole-2,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With triphenylphosphine In dichloromethane at 20℃; for 24h;

Reference： [1]Yavari; Nasiri; Djahaniani [Polish Journal of Chemistry, 2004, vol. 78, # 10, p. 1871 - 1876]

9
[ 5027-32-7 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 4,5,5-triacetyl-3-methylcyclopent-3-ene-1,2-dicarboxylate [ No CAS ]

Reference： [1]Mendeleev Communications,2005,vol. 15,p. 250 - 252

10
[ 54078-29-4 ]
[ 931-53-3 ]
[ 66086-33-7 ]
di-tert-butyl-2'-cyclohexyliminospiro[1,8-diazaflorene-9,5'(1')-oxacyclopant(3')ene]-3',4'-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	In dichloromethane at 38℃;

Reference： [1]Maghsoodlou, Malek Taher; Hazeri, Nourollah; Khorassani, Sayyed Mostafa Habibi; Marandi, Ghasem; Nassiri, Mahmoud [Journal of Heterocyclic Chemistry, 2006, vol. 43, # 2, p. 481 - 484]

11
[ 54078-29-4 ]
[ 66086-33-7 ]
[ 2769-71-3 ]
di-tert-butyl-2'-(2,6-dimethylphenylimino)spiro[1,8-diazaflorene-9,5'(1')-oxacyclopant(3')ene]-3',4'-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	In dichloromethane at 38℃;

12
[ 442-51-3 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 2-(harmin-1-yl)-3-(triphenylphosphoranylidene)butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2006,vol. 181,p. 567 - 572

13
[ 136-85-6 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 2-(5-methylbenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]
di-tert-butyl 2-(6-methylbenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2006,vol. 181,p. 865 - 877

14
[ 94-97-3 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 2-(6-chlorobenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]
di-tert-butyl 2-(5-chlorobenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2006,vol. 181,p. 865 - 877

15
[ 66086-33-7 ]
[ 2198-53-0 ]
[ 603-35-0 ]
di-tert-butyl 2-(2,6-dimethylacetanilide-N₁-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	In ethyl acetate at 20℃; for 6h;

Reference： [1]Maghsoodlou, Malek Taher; Hazeri, Norollah; Khorassani, Sayyed Mostafa Habibi; Heydari, Reza; Nassiri, Mahmoud; Marandi, Ghasem; Moeeni, Zohreh; Niromand, Uranous; Torbaghan, Zahra Eskandari [Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 4, p. 865 - 877]

16
[ 5018-30-4 ]
[ 66086-33-7 ]
[ 603-35-0 ]
2,3-di-tert-butyl 1,1-dimethyl 1-methoxy-3-(1,1,1-triphenyl-λ⁵-phosphanylidene)-1,1,2,3-propanetetracarboxylate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2007,vol. 182,p. 595 - 600

17
[ 3148-73-0 ]
[ 66086-33-7 ]
[ 1038-95-5 ]
di-tert-butyl 2-(N,N'-diacetylhydrazino)-3-(tri-p-tolylphosphanylidene)butanedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	In acetone at -10℃;

Reference： [1]Sabounchei, Seyyed Javad; Nemattalab, Hassan [Journal of Chemical Research, 2007, # 6, p. 353 - 355]

18
[ 3148-73-0 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 2-(N,N'-diacetylhydrazino)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	In acetone at -10℃;

Reference： [1]Sabounchei, Seyyed Javad; Nemattalab, Hassan [Journal of Chemical Research, 2007, # 6, p. 353 - 355]

19
[ 5053-24-7 ]
[ 66086-33-7 ]
[ 64035-64-9 ]
pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid di-tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	Stage #1: 2-methylthio-1,3-thiazole; Trimethylsilylmethyl trifluoromethanesulfonate In acetonitrile at 20℃; for 0.5h; Stage #2: Di-tert-butyl acetylenedicarboxylate With cesium fluoride In acetonitrile at 20℃; for 2h; Further stages.;

Reference： [1]Berry, Craig R.; Zificsak, Craig A.; Gibbs, Alan C.; Hlasta, Dennis J. [Organic Letters, 2007, vol. 9, # 21, p. 4099 - 4102]

20
[ 66086-33-7 ]
[ 30448-43-2 ]

Reference： [1]Chemische Berichte,1980,vol. 113,p. 531 - 541

21
[ 40842-04-4 ]
[ 66086-33-7 ]
C₂₀H₂₈O₆ [ No CAS ]
C₂₀H₂₈O₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
21%	With hydrogen In dichloromethane at 20℃;

Reference： [1]Tanaka, Ken; Sagae, Hiromi; Toyoda, Kazuki; Hirano, Masao [Tetrahedron, 2008, vol. 64, # 5, p. 831 - 846]

22
[ 52522-40-4 ]
[ 66086-33-7 ]
[PdC₄(COOt-Bu)₄]_n [ No CAS ]

Reference： [1]Organometallics,2005,vol. 24,p. 5537 - 5548

23
[ 1438-16-0 ]
[ 66086-33-7 ]
tert-butyl (5-oxo-2-thioxo-[1,3,4]thiadiazinan-6-ylidene)acetate [ No CAS ]

Reference： [1]Synthetic Communications,2008,vol. 38,p. 3700 - 3705

24
[ 94-97-3 ]
[ 66086-33-7 ]
[ 603-35-0 ]
di-tert-butyl 2-(5-chlorobenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2008,vol. 183,p. 2578 - 2583

25
[ 461-89-2 ]
[ 66086-33-7 ]
di-tert-butyl 2-(6-azauracil-3-yl)-3-(triphenylphosphoranylidene)-butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2009,vol. 184,p. 2959 - 2979

26
[ 2386-25-6 ]
[ 66086-33-7 ]
[ 603-35-0 ]
[ 1235482-09-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	In ethyl acetate at -5 - 20℃;

Reference： [1]Location in patent: experimental part Habibi-Khorassani, Sayyed Mostafa; Ebrahimi, Ali; Maghsoodlou, Malek Taher; Charati, Faramarz Rostami; Kazemian, Mohammad Amin; Karimi, Pouya [Phosphorus, Sulfur and Silicon and the Related Elements, 2010, vol. 185, # 3, p. 559 - 566]

27
[ 461-89-2 ]
[ 66086-33-7 ]
[ 603-35-0 ]
[ 1228566-69-5 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2011,vol. 186,p. 21 - 30

28
[ 66086-33-7 ]
[ 615-76-9 ]
[ 603-35-0 ]
[ 1268809-90-0 ]

Yield	Reaction Conditions	Operation in experiment
90%	In diethyl ether at -5 - 20℃; for 10h; chemoselective reaction;

Reference： [1]Location in patent: experimental part Habibi-Khorassani, Sayyed Mostafa; Maghsoodlou, Malek Taher; Hazeri, Nourallah; Bagherpour, Khatereh; Rostamizadeh, Mohsen; Najafi, Hamed [Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 1, p. 21 - 30]

29
[ 6332-56-5 ]
[ 66086-33-7 ]
[ 603-35-0 ]
[ 1257392-27-0 ]

Reference： [1]Collection of Czechoslovak Chemical Communications,2010,vol. 75,p. 785 - 805

30
[ 931-53-3 ]
[ 92-77-3 ]
[ 66086-33-7 ]
[ 1357266-46-6 ]

Yield	Reaction Conditions	Operation in experiment
89%	In ethyl acetate for 24h; Reflux;

Reference： [1]Location in patent: experimental part Hassanabadi, Alireza; Mosslemin, Mohammad H.; Anary-Abbasinejad, Mohammad; Ghasemi, Maryam [Synthetic Communications, 2011, vol. 41, # 24, p. 3714 - 3719]

31
[ 1134203-14-7 ]
[ 7188-38-7 ]
[ 66086-33-7 ]
di(tert-butyl) 2-[(tert-butylimino)methylene]-3-{(5Z)-5-[4-(dimethylamino)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}succinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	In dichloromethane at 20℃; for 48h;

Reference： [1]Location in patent: experimental part Baharfar, Robabeh; Porahmad, Nasim [Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 9, p. 1988 - 1996]

32
[ 931-53-3 ]
[ 66086-33-7 ]
[ 791-31-1 ]
[ 1344030-63-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	In dichloromethane at 20℃; for 8h;	Typical procedure for the preparation of dimethyl 2-((2,4,4-trimethylpentan-2-ylimino)methylene)-3-(triphenylsilyloxy)succinate (4a): General procedure: To a magnetically stirred solution of triphenylsilanol (0.28 g, 1.0 mmol) and dimethyl acetylenedicarboxylate (0.14 g, 1.0 mmol) in 10 mL CH2Cl2 was added, 1,1,3,3-tetramethyl-butyl isocyanide (0.14 g, 1.0 mmol). The mixture was finally stirred for 8 h at room temperature. The solvent was removed under vacuum and the products were thus obtained as yellow oil, yield 0.51 g (92%);

Reference： [1]Sarvary, Afshin; Shaabani, Shabnam; Shaabani, Ahmad; Ng, Seikweng [Tetrahedron Letters, 2011, vol. 52, # 45, p. 5930 - 5933]

33
[ 7188-38-7 ]
[ 66086-33-7 ]
[ 791-31-1 ]
[ 1344030-60-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	In dichloromethane at 20℃; for 8h;	Typical procedure for the preparation of dimethyl 2-((2,4,4-trimethylpentan-2-ylimino)methylene)-3-(triphenylsilyloxy)succinate (4a): General procedure: To a magnetically stirred solution of triphenylsilanol (0.28 g, 1.0 mmol) and dimethyl acetylenedicarboxylate (0.14 g, 1.0 mmol) in 10 mL CH2Cl2 was added, 1,1,3,3-tetramethyl-butyl isocyanide (0.14 g, 1.0 mmol). The mixture was finally stirred for 8 h at room temperature. The solvent was removed under vacuum and the products were thus obtained as yellow oil, yield 0.51 g (92%);

Reference： [1]Sarvary, Afshin; Shaabani, Shabnam; Shaabani, Ahmad; Ng, Seikweng [Tetrahedron Letters, 2011, vol. 52, # 45, p. 5930 - 5933]

34
[ 66086-33-7 ]
[ 14542-93-9 ]
[ 791-31-1 ]
[ 1344030-57-4 ]

Yield	Reaction Conditions	Operation in experiment
84%	In dichloromethane at 20℃; for 8h;	Typical procedure for the preparation of dimethyl 2-((2,4,4-trimethylpentan-2-ylimino)methylene)-3-(triphenylsilyloxy)succinate (4a): General procedure: To a magnetically stirred solution of triphenylsilanol (0.28 g, 1.0 mmol) and dimethyl acetylenedicarboxylate (0.14 g, 1.0 mmol) in 10 mL CH2Cl2 was added, 1,1,3,3-tetramethyl-butyl isocyanide (0.14 g, 1.0 mmol). The mixture was finally stirred for 8 h at room temperature. The solvent was removed under vacuum and the products were thus obtained as yellow oil, yield 0.51 g (92%);

Reference： [1]Sarvary, Afshin; Shaabani, Shabnam; Shaabani, Ahmad; Ng, Seikweng [Tetrahedron Letters, 2011, vol. 52, # 45, p. 5930 - 5933]

35
[ 4113-97-7 ]
[ 7188-38-7 ]
[ 66086-33-7 ]
[ 1381804-53-0 ]

Yield	Reaction Conditions	Operation in experiment
89%	In 1,4-dioxane at 25℃; for 12h;

Reference： [1]Location in patent: scheme or table Baharfar, Robabeh; Baghbanian, Seyed Meysam [Chinese Chemical Letters, 2012, vol. 23, # 6, p. 677 - 680]

36
[ 66086-33-7 ]
[ 30478-88-7 ]
[ 1422144-73-7 ]

Reference： [1]Combinatorial Chemistry and High Throughput Screening,2012,vol. 15,p. 816 - 821

37
[ 66086-33-7 ]
[ 60-56-0 ]
di-tert-butyl 2-(1-methylimidazol-2-yl-sulfanyl)fumarate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With pyridine; In dichloromethane; at 20℃; for 2h;	General procedure: A mixture of pyridine (1 mmol) in 3 mL dichloromethane was added dropwise to a magnetically stirred solution of 2-mercapto-1-methylimidazole or 5-mercapto-1-methyltetrazole (1 mmol) and acetylenic esters (1 mmol) in 15 mL dichloromethane. The reaction mixture was then stirred for 2 h at room temperature. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using hexane-ethyl acetate as eluent. The solvent was removed under reduced pressure to afford the product.

Reference： [1]Journal of Chemical Research,2013,vol. 37,p. 523 - 525

38
[ 66086-33-7 ]
[ 13183-79-4 ]
di-tert-butyl 2-(1-methyltetrazol-2-yl-sulfanyl)fumarate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With pyridine; In dichloromethane; at 20℃; for 2h;	General procedure: A mixture of pyridine (1 mmol) in 3 mL dichloromethane was added dropwise to a magnetically stirred solution of 2-mercapto-1-methylimidazole or <strong>[13183-79-4]5-mercapto-1-methyltetrazole</strong> (1 mmol) and acetylenic esters (1 mmol) in 15 mL dichloromethane. The reaction mixture was then stirred for 2 h at room temperature. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using hexane-ethyl acetate as eluent. The solvent was removed under reduced pressure to afford the product.

Reference： [1]Journal of Chemical Research,2013,vol. 37,p. 523 - 525

39
[ 119-65-3 ]
[ 28868-76-0 ]
[ 66086-33-7 ]
di-tert-butyl 2-(1-(1,3-dimethoxy-1,3-dioxopropan-2-ylidene)isoquinolin-2(1H)-yl)maleate [ No CAS ]

Reference： [1]Chinese Chemical Letters,2013,vol. 24,p. 979 - 983

40
[ 1003-56-1 ]
[ 66086-33-7 ]
di-tert-butyl 4-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 7661 - 7664
Angew. Chem.,2014,vol. 126,p. 7793 - 7796,4

41
[ 1003-56-1 ]
[ 66086-33-7 ]
(1S,6S)-di-tert-butyl 4-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]
(1R,6R)-di-tert-butyl 4-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 7661 - 7664
Angew. Chem.,2014,vol. 126,p. 7793 - 7796,4

42
[ 1003-68-5 ]
[ 66086-33-7 ]
di-tert-butyl 6-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 7661 - 7664
Angew. Chem.,2014,vol. 126,p. 7793 - 7796,4

43
[ 1003-68-5 ]
[ 66086-33-7 ]
(1S,6S)-di-tert-butyl 6-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]
(1R,6R)-di-tert-butyl 6-methyl-3-oxo-2-azabicyclo[4.2.0]octa-4,7-diene-7,8-dicarboxylate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2014,vol. 53,p. 7661 - 7664
Angew. Chem.,2014,vol. 126,p. 7793 - 7796,4

44
[ 66086-33-7 ]
[ 575-03-1 ]
[ 555-16-8 ]
di-tert-butyl (2E)-2-[hydroxy(4-nitrophenyl)methyl]-3-{(2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)oxy}but-2-enedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
30%	With triethylamine; In tetrahydrofuran; at 20℃;	General procedure: To a magnetically-stirred solution of 7-hydroxycoumarin derivatives (2 mmol), aromatic aldehydes (2 mmol) and NEt3 (2 mmol) in THF (8 mL) a mixture of dialkyl acetylenedicarboxylate (2 mmol) in THF (2 mL) was added in 15 min. The reaction mixture was then allowed to stand at room temperature for 0.5-10 h. After completion of the reaction as indicated by thin-layer chromatography (TLC) (n-hexane/EtOAc, 1:1), the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (Merck, 230-400 mesh) using a mixture of n-hexane/EtOAc (1:1) as eluent to afford the pure product as a light yellow powder.

Reference： [1]Journal of the Brazilian Chemical Society,2015,vol. 26,p. 218 - 223

45
[ 110-26-9 ]
[ 66086-33-7 ]
[ 121-45-9 ]
di-tert-butyl 2-[acryloyl(acryloylaminomethyl)amino]-3-(dimethyphosphono)succinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	In dichloromethane; at 20℃; for 5.25h;	General procedure: To a stirred mixture of N,N-methylenediacrilamide (0.154 g, 1 mmol) and dialkylacetylenedicarboxylate (1 mmol) in CH2Cl2 (5 mL) was added, drop wise, a mixture oftrialkyl(aryl) phosphite (1 mmol) in CH2Cl2 (3 mL) at room temperature over 15 min.After completion of the reaction (about 5 h), as indicated by TLC (EtOAc/hexane, 3:2), thesolvent was removed under reduced pressure, the solid residue was washed with cold Et2O(2 × 5 mL), to afford the pure adducts.

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2015,vol. 190,p. 440 - 448

46
[ 110-26-9 ]
[ 66086-33-7 ]
[ 122-52-1 ]
di-tert-butyl 2-[acryloyl(acryloylaminomethyl)amino]-3-(diethylphosphono)succinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	In dichloromethane; at 20℃; for 5.25h;	General procedure: To a stirred mixture of N,N-methylenediacrilamide (0.154 g, 1 mmol) and dialkylacetylenedicarboxylate (1 mmol) in CH2Cl2 (5 mL) was added, drop wise, a mixture oftrialkyl(aryl) phosphite (1 mmol) in CH2Cl2 (3 mL) at room temperature over 15 min.After completion of the reaction (about 5 h), as indicated by TLC (EtOAc/hexane, 3:2), thesolvent was removed under reduced pressure, the solid residue was washed with cold Et2O(2 × 5 mL), to afford the pure adducts.

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2015,vol. 190,p. 440 - 448

47
[ 101-02-0 ]
[ 110-26-9 ]
[ 66086-33-7 ]
di-tert-buthyl 2-[acryloyl(acryloylaminomethyl)amino]-3-(diphenylphosphono)succinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	In dichloromethane; at 20℃; for 5.25h;	General procedure: To a stirred mixture of N,N-methylenediacrilamide (0.154 g, 1 mmol) and dialkylacetylenedicarboxylate (1 mmol) in CH2Cl2 (5 mL) was added, drop wise, a mixture oftrialkyl(aryl) phosphite (1 mmol) in CH2Cl2 (3 mL) at room temperature over 15 min.After completion of the reaction (about 5 h), as indicated by TLC (EtOAc/hexane, 3:2), thesolvent was removed under reduced pressure, the solid residue was washed with cold Et2O(2 × 5 mL), to afford the pure adducts.

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2015,vol. 190,p. 440 - 448

48
[ 2510-03-4 ]
[ 66086-33-7 ]
di(tert-butyl) 2-dicyano(1,2-dihydro-4-naphthalenyl)methyl-3-(1-dicyanomethylene-1,2,3,4-tetrahydro-2-naphthalenyl)succinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With triethylamine In ethanol at 20℃; for 10h;	General procedure for the preparation of compounds 5a-d General procedure: To a mixture of 2-(3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile 4 (2mmol) and dialkyl acetylenedicarboxylate 2 (1mmol) in EtOH (5mL) was added triethylamine (6 drops). The mixture was stirred at room temperature. After completion, monitored by TLC, the mixture was filtered and the precipitate washed with ethanol (2×4mL) to afford the pure product 5a-d.

Reference： [1]Alizadeh, Abdolali; Hosseini, Seyed Yasub; Sedighian, Hadi; Bayat, Fahimeh; Zhu, Zhe; Dusek, Michal [Tetrahedron, 2015, vol. 71, # 41, p. 7885 - 7891]

49
[ 119-65-3 ]
[ 29310-88-1 ]
[ 66086-33-7 ]
di(tert-butyl) 3-[(2-oxo-2H-chromen-3-yl)carbonyl]pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	Stage #1: isoquinoline; 3-bromoacetylcoumarin In acetonitrile at 20℃; for 1h; Stage #2: Di-tert-butyl acetylenedicarboxylate With triethylamine In acetonitrile for 4h;	General procedure (exemplified for 3a) General procedure: A solution of isoquinoline (1 mmol, 129 mg) and 3-(2-bromoacetyl)coumarin (1a) (1 mmol, 266 mg) in acetonitrile (5 ml) were magnetically stirred for 1 h at r.t. Then, triethylamine (1 mmol, 101 mg) was added to the mixture and orange participate was formed. Then, dialkyl acetylenedicarboxylate (1 mmol, 142 mg) was added dropwise to the mixture during 5 min and the solution stirred for 4 h. After completion of the reaction [about 5 h; TLC (AcOEt/hexane 1:3)], the mixture was filtered and the precipitate was washed with EtOH (4 ml) to afford the pure product 3a-i (Table 1).

Reference： [1]Alizadeh, Abdolali; Ghanbaripour, Rashid [Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8785 - 8796]

50
[ 4160-61-6 ]
[ 66086-33-7 ]
[ 603-35-0 ]
C₃₇H₄₃O₇PS [ No CAS ]
C₃₇H₄₃O₇PS [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane; at -10 - 20℃;	General procedure: To a magnetically stirred solution of methyl 4-oxotetrahydro-2H-thiopyran-3-carboxylate (0.35 g, 2 mmol) and triphenylphosphine (0.52 g, 2 mmol) in CH2Cl2 (10 mL) at-10 C was added drop wise a solution of dialkyl acetylenedicarboxylate (2 mmol) in CH2Cl2 (3 mL) over 10 min. The mixture was allowed to stand at room temperature for 20-30 min. The solvent was removed under reduced pressure andthe residue was precipitated in diethyl ether then filtered andd ried. The products 3a-cwere obtained aswhite powders. Compounds 3a-c were refluxed in toluene for 2 h. After completionof the reaction as indicated by thin layer chromatography (TLC; n-hexane/EtOAc, 3:1), the solvent was removed underreduced pressure and viscous residue was purified by silica gel (Merck silica gel, 230-400 mesh) column chromatography usingn-hexane/ethyl acetate (7:3). The solvent was removed under reduced pressure and products 5a-c were obtained as yellowoils.

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2016,vol. 191,p. 939 - 943

51
[ 66086-33-7 ]
[ 3867-18-3 ]
tert-butyl 3-(3-(tert-butoxy)-2-hydroxy-3-oxopropyl)-1H-indole-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%	In dimethyl sulfoxide at 80℃; for 12h; Schlenk technique;
66%	In dimethyl sulfoxide at 120℃; for 24h;	46 Example 46 tert-Butyl 3- (3- (tert-butoxy) -2-hydroxy-3-oxopropyl) -1H-indole-2-carboxylate Take a reaction tube,Adding 2-vinyl aniline 24 mg,Butynedoate di-tert-butyl ester 250 mg,Dimethyl sulfoxide 1 mL,And the mixture was stirred at 120 ° C for 24 hours.After completion of the reaction, 10 mL of ethyl acetate was added to harden the reaction, washed with 5 mL of brine, the organic phase was separated, the aqueous phase was extracted three times with ethyl acetate,Combine organic phase,Separated by column chromatography to give 3- (3- (tert-butoxy) -2-hydroxy-3-oxopropyl) lH-indole-2-carboxylate 48mg, yield 66%.

Reference： [1]Shen, Tao; Zhang, Yiqun; Liang, Yu-Feng; Jiao, Ning [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13147 - 13150]
[2]Current Patent Assignee: PEKING UNIVERSITY - CN106831533, 2017, A Location in patent: Paragraph 0307; 0308; 0309; 0310

52
[ 931-53-3 ]
[ 550-24-3 ]
[ 66086-33-7 ]
di-tert-butyl 2-(cyclohexylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

53
[ 119072-55-8 ]
[ 550-24-3 ]
[ 66086-33-7 ]
di-tert-butyl 2-(tert-butylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

54
[ 550-24-3 ]
[ 66086-33-7 ]
[ 119072-54-7 ]
di-tert-butyl 2-(2,6-dimethylphenylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

55
[ 66086-33-7 ]
[ 7633-38-7 ]
[ 18305-60-7 ]

Yield	Reaction Conditions	Operation in experiment
64.912 % de	With formic acid; triethanolamine; palladium dichloride In N,N-dimethyl-formamide at 50℃; for 24h; Inert atmosphere; Overall yield = 34 %Spectr.;

Reference： [1]Suzuki, Hideyuki; Satoh, Ikkyu; Nishioka, Hiromi; Takeuchi, Yasuo [Tetrahedron Letters, 2017, vol. 58, # 40, p. 3834 - 3837]

56
[ 66086-33-7 ]
[ 4996-21-8 ]
[ 100-63-0 ]
di-t-butyl 4-(4-chlorophenyl)-1-(phenylamino)-1H-pyrrole-2,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With triphenylphosphine; In dichloromethane; at 20℃; for 10h;	General procedure: Amixture of dimethyl acetylenedicarboxylate (142 mg, 1 mmol) in CH2Cl2 (3 mL) was added drop wise to amagnetically stirred solution of triphenylphosphine (262 mg, 1 mmol) and phenylhydrazine (108 mg, 1 mmol)in CH2Cl2 (10 mL). The reaction mixture was then stirred for 1 min. 4-Chlorophenylglyoxal monohydrate (186mg, 1 mmol) was added, and the reaction mixture was stirred for more 10 hr at room temperature. Thesolvent was evaporated, and the residue was purified by column chromatography on silica gel using ethylacetate-hexane mixture (4:1 ratio) as eluent to give the product (308 mg, 80%) as a white solid.

Reference： [1]Arkivoc,2017,vol. 2017,p. 141 - 147

57
[ 15119-34-3 ]
[ 66086-33-7 ]
di-tert-butyl 2-(3-cyano-2-oxo-2H-chromen-4-yl)but-2-enedioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	In dichloromethane; at 20℃; for 6.08333h;	General procedure: A stirred solution of pyridine (1.0 mmol) and <strong>[15119-34-3]2-oxo-2H-chromene-3-carbonitrile</strong> (1.0 mmol) in CH2Cl2 (15 mL) was treated dropwise with a solution of the acetylenic ester (1.0 mmol) in CH2Cl2 (2 mL) over 5min via a syringe. The reaction mixture was then stirred at roomtemperature for about 6 h. On reaction completion, as monitoredby TLC, the solvent was removed under vacuum and the products7a-g, were crystallised from the residue in ethanol to afford thebenzopyrano[3,4-a]quinolizine 7. For products 8a,b, the residue waspurified through plate chromatography (eluent: EtOAc/petroleumether) using 100-200 mesh silica gel to afford the desired product 8.

Reference： [1]Journal of Chemical Research,2017,vol. 41,p. 688 - 692

58
[ 66086-33-7 ]
[ 52267-39-7 ]
trans-1-benzyl 2,3-di-tert-butyl 1-methyl cyclopropane-1,1,2,3-tetracarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85.9%	With triphenyl-arsane; In ethanol; at 0 - 20℃; for 240h;	Triphenylarsine (3.17 g, 1 1 mmol) was dissolved in anhydrous EtOH (50 mL) and mixed with <strong>[52267-39-7]benzyl methyl malonate</strong> (4.6 g, 22.09 mmol). After the solution was cooled in an ice-water bath, it was added with di-tert-butyl acetylene dicarboxylate (5 g, 22.09 mmol). The reaction mixture was stirred at 0 C to room temperature for 10 days. EtOH was removed by rotary evaporation, and the residue was purified through silica gel column chromatography (220 g, 0 to 10 % EtOAc and hexane). Yield 9.2 g, 85.9 %. Ion found by LCMS: [M - 2tBu + H]+ = 323.

Reference： [1]Patent: WO2018/6063,2018,A1 .Location in patent: Page/Page column 386

59
[ 4437-22-3 ]
[ 66086-33-7 ]
di-tert-butyl (3aRS,6SR,7RS,9aSR)-6H,7H-3a,6:7,9a-diepoxybenzo[de]isochromene-6a,9b(1H,3H)-dicarboxylate [ No CAS ]
di-tert-butyl (3aRS,6SR,6aS,7SR,9aRS,9bSR)-6a,9b-dihydro-6H,7H-3a,6:7,9a-diepoxybenzo[de]isochromene-4,5(1H,3H)-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 46% 2: 20%	In benzene at 80℃; for 47h;

60
[ 4437-22-3 ]
[ 66086-33-7 ]
di-tert-butyl (3aRS,6SR,6aS,7SR,9aRS,9bSR)-6a,9b-dihydro-6H,7H-3a,6:7,9a-diepoxybenzo[de]isochromene-4,5(1H,3H)-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
20%	In o-xylene at 140℃; for 10h;
15%	In o-xylene at 140℃; for 10h; chemoselective reaction;

Reference： [1]Borisova, Kseniya K.; Kvyatkovskaya, Elizaveta A.; Nikitina, Eugeniya V.; Aysin, Rinat R.; Novikov, Roman A.; Zubkov, Fedor I. [Journal of Organic Chemistry, 2018, vol. 83, # 8, p. 4840 - 4850]
[2]Kvyatkovskaya, Elizaveta A.; Borisova, Kseniya K.; Epifanova, Polina P.; Senin, Aleksey A.; Khrustalev, Victor N.; Grigoriev, Mikhail S.; Bunev, Alexander S.; Gasanov, Rovshan E.; Polyanskii, Kirill B.; Zubkov, Fedor I. [New Journal of Chemistry, 2021, vol. 45, # 41, p. 19497 - 19505]

61
[ 13678-67-6 ]
[ 66086-33-7 ]
di-tert-butyl (3aRS,6SR,7RS,9aSR)-6H,7H-3a,6:7,9a-diepoxybenzo[de]isothiochromene-6a,9b(1H,3H)-dicarboxylate [ No CAS ]
C₂₂H₂₈O₆S [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2018,vol. 83,p. 4840 - 4850

62
[ 66086-33-7 ]
[ 74965-38-1 ]
tri-tert-butyl quinoline-1,2,3(2H)-tricarboxylate [ No CAS ]

Reference： [1]Organic Letters,2018,vol. 20,p. 4584 - 4588

63
[ 13678-67-6 ]
[ 66086-33-7 ]
di-tert-butyl (3aRS,6SR,7RS,9aSR)-6H,7H-3a,6:7,9a-diepoxybenzo[de]isothiochromene-6a,9b(1H,3H)-dicarboxylate [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2020,vol. 2020,p. 156 - 161

64
[ 2033-29-6 ]
[ 66086-33-7 ]
C₁₄H₁₄Cl₂N₂O₃ [ No CAS ]

Reference： [1]RSC Advances,2021,vol. 11,p. 24466 - 24473

65
[ 66086-33-7 ]
[ 14925-09-8 ]
C₂₅H₂₇NO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31%	With bis(1-methyl-1-phenylethyl)peroxide In dimethyl sulfoxide at 20℃; for 24h; Irradiation;	15 Implementation example 15 0.018g (0.1mmol) N-methylbenzidine-2-amine 1a, 0.045g (0.2mmol) butyne dicarboxylate 2c, 0.054g (0.2mmol) dicumyl peroxide , 2mL DMSO was sequentially added to a 10ml thick-walled pressure-resistant tube, under the irradiation of 24W blue LED, the reaction was magnetically stirred for 24h, and the progress of the reaction was monitored by TLC. After the reaction is over, column chromatography is separated [petroleum ether (6090)/ethyl acetate (15:1)] to obtain 8-phenyl-3,4-dicarboxylate tert-butyl quinoline 3i, a white solid 13mg The yield was 31%.

Reference： [1]Current Patent Assignee: ANHUI UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN113444041, 2021, A Location in patent: Paragraph 0047-0048

66
[ 4437-22-3 ]
[ 66086-33-7 ]
di-tert-butyl (2RS,5SR)-2-[(cyclopenta-1,3-dien-1-ylmethoxy)methyl]-2,5-diethenyl-2,5-dihydrofuran-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: benzene / 47 h / 80 °C 2: C₃₀H₃₇Cl₂N₃Ru / benzene / 6 h / 100 °C / 1500.15 Torr / Autoclave

Reference： [1]Kvyatkovskaya, Elizaveta A.; Borisova, Kseniya K.; Epifanova, Polina P.; Senin, Aleksey A.; Khrustalev, Victor N.; Grigoriev, Mikhail S.; Bunev, Alexander S.; Gasanov, Rovshan E.; Polyanskii, Kirill B.; Zubkov, Fedor I. [New Journal of Chemistry, 2021, vol. 45, # 41, p. 19497 - 19505]

67
[ 4437-22-3 ]
[ 66086-33-7 ]
di-tert-butyl (2RS,2aSR,3RS,5aSR,8aSR,8bRS)-2,8a-diethenyl-2a,8,8a,8b-tetrahydro-2H,3H-3,5a-epoxyfuro[2,3,4-de]isochromene-4,5(6H)-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: o-xylene / 10 h / 140 °C 2: C₃₀H₃₇Cl₂N₃Ru / benzene / 6 h / 100 °C / 1500.15 Torr / Autoclave

68
[ 4437-22-3 ]
[ 66086-33-7 ]
di-tert-butyl (3aRS,6SR,7RS,9aSR)-6H,7H-3a,6:7,9a-diepoxybenzo[de]isochromene-6a,9b(1H,3H)-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	In benzene at 80℃; for 47h; chemoselective reaction;

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 66086-33-7 ]

Quality Control of [ 66086-33-7 ]

Related Doc. of [ 66086-33-7 ]

Product Details of [ 66086-33-7 ]

Safety of [ 66086-33-7 ]

Application In Synthesis of [ 66086-33-7 ]

[ 66086-33-7 ] Synthesis Path-Upstream 1~3

[ 66086-33-7 ] Synthesis Path-Downstream 1~68

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry