6628-68-8|Diethyl 2-phenethylmalonate| Ambeed

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Quality Control of [ 6628-68-8 ] Purity: 97% SDS Specification

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Product Details of [ 6628-68-8 ]

CAS No. :	6628-68-8
Formula :	C₁₅H₂₀O₄
M.W :	264.32
SMILES Code :	O=C(OCC)C(CCC1=CC=CC=C1)C(OCC)=O
MDL No. :	MFCD00026887
InChI Key :	LMFLGETWXFOVMQ-UHFFFAOYSA-N
Pubchem ID :	81119

Safety of [ 6628-68-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 6628-68-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6628-68-8 ]

[ 6628-68-8 ] Synthesis Path-Downstream 1~35

1
[ 504-29-0 ]
[ 6628-68-8 ]
3-phenethyl-pyrido[1,2-a]pyrimidine-2,4-dione [ No CAS ]

References: [1]Recueil des Travaux Chimiques des Pays-Bas,1954,vol. 73,p. 376,380.

2
[ 109-65-9 ]
[ 6628-68-8 ]
[ 854841-86-4 ]

References: [1]Annales de Chimie (Cachan, France),1931,vol. <10> 15,p. 425,505, 506.

3
[ 64-17-5 ]
[ 6628-68-8 ]
[ 3168-90-9 ]
[ 141-52-6 ]
14-methyl-12-oxo-6,7,12,13,14,15,16,17-octahydro-cyclopenta[a]phenanthrene-8-carboxylic acid [ No CAS ]

References: [1]Journal of the Chemical Society,1936,p. 50.

4
[ 6628-68-8 ]
[ 3168-90-9 ]
14-methyl-12-oxo-6,7,12,13,14,15,16,17-octahydro-cyclopenta[a]phenanthrene-8-carboxylic acid [ No CAS ]

References: [1]Journal of the Chemical Society,1936,p. 50.

5
[ 6628-68-8 ]
[ 3709-21-5 ]

Yield	Reaction Conditions	Operation in experiment
65%	With potassium hydroxide; In water;	b 2-Phenylethylmalonic Acid A mixture of diethyl 2-phenylethylmalonate (3.61 g) and potassium hydroxide (1.69 g, 2.5 eq) in water (15 ml) was refluxed for 2 h and cooled to room temperature. The solution was washed with diethyl ether (210 ml) and then acidified to pH 2 (5M hydrochloric acid). The aqueous phase was extracted with diethyl ether (220 ml). The combined extracts were washed with water (2*20 ml), saturated brine (20 ml), dried (MgSO4) and evaporated to give the title compound as a white solid (1.85 g, 65%); νmax (KBr) 3080(br), 1705 cm-1; δH [(CD3)2 CO], 2.18 (2H, m, CH2), 2.70 (2H, m, CH2), 3.40 (1H, t, J 7.4 Hz, CH), 7.25 (5H, m, Ph). DCIMS MNH4+
	With potassium hydroxide; In ethanol; at 0 - 20℃; for 24h;	General procedure: Sodium (1.0 equiv) is slowly added and dissolved in abs. ethanol (1.4mL/mmol). Then, diethyl malonate (1.0 equiv) is added dropwise and the resulting mixture is stirred during 30 min at room temperature. Then, the respective bromide is added dropwise at room temperature and the resulting mixture is refluxed during 24 h. After removal of volatiles, H2O is added and extractions with Et2O (×3) are performed. The combined organic layers are dried with Na2SO4 and evaporated to afford the crude product which is assumed to contain only the target monoalkylated diethyl ester of type 6. The residue is dissolved in EtOH (0.5 mL/mmol of 6) and cooled at 0C. At the same temperature, a solution of KOH (2.0 equiv) in EtOH (1.5 mL/mmol of 6) is slowly added. The mixture is stirred at rt and the progress of the reaction is followed by TLC, until diethylester 6 is fully consumed (if needed, up to 1.0 equiv of KOH is gradually added). Typically, reaction time is 24h. The mixture is concentrated and the residue is diluted H2O and Et2O. The aqueous phase is separated, washed with Et2O (×2), acidified with HCl 2M to pH ~1 and extracted with AcOEt (×3). The combined organic layers are dried over Na2SO4 and evaporated to afford diacid of type 7. The latter is dissolved/suspended to ΑcOEt (1.8 mL/mmol of 7) and Et2NH (1.2 equiv) is added slowly at 0 C. The temperature is raised at rt, ΗCHO (1.4 equiv) is added and the mixture is refluxed for 4 h. Then, the mixture is concentrated, treated with aq. NaHCO3 5% and washed with Et2O (×3). The aqueous phase is acidified with HCl 2M to pH ~1 and extracted with AcOEt (×3). The combined organic layers are dried over Na2SO4 and evaporated to afford acrylic acid of type 3 inadequately pure form to be used in the P-Michael reaction without further purification.

References: [1]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 5933 - 5949.
[2]Journal of the American Chemical Society,2020,vol. 142,p. 20942 - 20947.
[3]Patent: US6048852,2000,A .
[4]Journal of Medicinal Chemistry,1984,vol. 27,p. 967 - 978.
[5]Chemische Berichte,1906,vol. 39,p. 2210.
[6]Journal of the American Chemical Society,1924,vol. 46,p. 2845.
[7]Chemical and Pharmaceutical Bulletin,1987,vol. 35,p. 2388 - 2393.
[8]Journal of Medicinal Chemistry,2001,vol. 44,p. 4170 - 4175.
[9]Inorganic Chemistry,2010,vol. 49,p. 3261 - 3270.
[10]Organic Letters,2021,vol. 23,p. 5054 - 5059.
[11]Molecules,2022,vol. 27.
[12]Chemical Communications,2022,vol. 58,p. 1135 - 1138.

6
[ 6628-68-8 ]
[ 27491-34-5 ]

References: [1]Journal of the American Chemical Society,1948,vol. 70,p. 3177.

7
[ 6628-68-8 ]
[ 51052-71-2 ]
[ 137307-63-2 ]

References: [1]Journal of the American Chemical Society,1924,vol. 46,p. 2845.
[2]Journal of the American Chemical Society,1924,vol. 46,p. 2845.

8
[ 6628-68-8 ]
[ 854830-69-6 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 2923.

9
[ 6628-68-8 ]
[ 177260-46-7 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 2923.

10
[ 6628-68-8 ]
[ 873975-09-8 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 2923.

11
[ 6628-68-8 ]
(2-cyclopentyl-ethyl)-phenethyl-malonic acid diethyl ester [ No CAS ]

References: [1]Journal of the American Chemical Society,1941,vol. 63,p. 2991.

12
[ 54918-70-6 ]
[ 6628-68-8 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1925,vol. <2> 109,p. 126,139.

13
[ 996-82-7 ]
[ 622-24-2 ]
[ 6628-68-8 ]

References: [1]Journal of the Chemical Society,1923,vol. 123,p. 1755 - 1766.

14
[ 6628-68-8 ]
[ 105-36-2 ]
[ 109809-38-3 ]

References: [1]Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine,1957,vol. 25/5 A,p. 17,20.

15
sodium diethylmalonate [ No CAS ]
[ 103-63-9 ]
[ 6628-68-8 ]

References: [1]Chemische Berichte,1939,vol. 72,p. 1551,1554.
[2]Annales de Chimie (Cachan, France),1938,vol. <11> 9,p. 5,82.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1936,vol. 202,p. 1679.

16
[ 996-82-7 ]
[ 103-63-9 ]
[ 6628-68-8 ]

References: [1]Bulletin de la Societe Chimique de France,1970,p. 219 - 230.

17
[ 6628-68-8 ]
[ 106-95-6 ]
[ 4375-32-0 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 2923.

18
[ 6628-68-8 ]
[ 106-95-6 ]
[ 174312-75-5 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 2923.

19
[ 6628-68-8 ]
[ 107-13-1 ]
[ 127983-02-2 ]

References: [1]Journal of the Chemical Society,1950,p. 1683,1684.

20
[ 6628-68-8 ]
[ 1518-28-1 ]

References: [1]Canadian Journal of Chemistry,1979,vol. 57,p. 1025 - 1032.

21
[ 1559-02-0 ]
[ 23402-69-9 ]
[ 6628-68-8 ]

References: [1]Tetrahedron Letters,1972,p. 997 - 1000.

22
[ 103-63-9 ]
[ 105-53-3 ]
[ 6628-68-8 ]

Yield	Reaction Conditions	Operation in experiment
72%	With hydrogenchloride; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; mineral oil;	EXAMPLE 1 STR7 Diethyl 2-[2-(phenyl)ethyl]malonate According to the described procedure (J. Med Chem. 1984, 27, 967-978), to a 2 liter 3-neck round bottom flask was attached a pressure equalized addition funnel and a water cooled reflux condenser. A large Teflon coated magnetic stirring bar was added and the flask flamed dried under nitrogen. Sodium hydride (60% in mineral oil, 42 g, 1.06 moles) was added to the flask and the mineral oil removed by washing the solid three times with 40 mL of hexane. One liter of dry tetrahydrofuran (THF) (distilled over potassium/benzophenone) was added to the flask under nitrogen. A mineral oil bubbler was attached by a rubber septum to the flask and diethyl malonate was added dropwise over 1 h, keeping the temperature <18 C. When hydrogen evolution had ceased, 197.5 g of 1-bromoethyl benzene (1.06 mole) was added dropwise over 30 minutes with cooling (<30). The solution was gently refluxed overnight. The mixture was cooled to room temperature and poured into 200 mL of ice water containing 150 mmole of HCl and stirred 5 minutes. The organic layer was separated and the aqueous layer extracted with 3100 mL of ether. The organic layers were combined and washed with 2100 mL of saturated sodium bicarbonate and 1*100 mL of brine. The solution was dried over anhydrous MgSO4. The ether was removed under reduced pressure and the product distilled under vacuum (bp=146-148ã1.5 mm Hg). Recovered 203 g of product (yield=72%). 1 H-NMR (CDCl3, 200 mHz, d, ppm,) 7.4-7.2 (m, 5H), 4.3-4.16 (q, 4H), 3.4-3.3 (t, 1H), 2.74-2.64 (t, 2H), 2.32-2.18 (q, 2H), 1.36-1.26 (t, 6H).
71%	In hexane; N,N-dimethyl-formamide;	a Diethyl 2-phenylethylmalonate A solution of diethyl malonate (6.07 ml, 40 mmol) in dimethyl formamide (60 ml) at 0 C. was treated portionwise with sodium hydride (1.6 g, 40 mmol, 60% dispersion in oil) and stirred for 0.25 h. 2-Phenylethyl bromide (5.48 ml, 40 mmol) in dimethylformarnmide (30 ml) was added dropwise. The mixture was warmed to room temperature and stirred for 1 h. The mixture was diluted with diethyl ether (300 ml), washed with water (4200 ml), saturated brine (100 ml), dried (MgSO4) and evaporated. Flash chromatography on silica, eluding with 1% ethyl acetate in hexane, gave the title compound as a colourless oil (7.55 g, 71%); νmax (CH2 Cl2), 1726 cm-1; δH (CDCl3), 1.27 (6H, t, J 7 Hz, 2CH3), 2.21 (2H, m, CH2), 2.68 (2H, m, CH2), 3.34 (1H, t, J 7.6 Hz, CH), 4.18 (4H, q, J 7 Hz, 2*OCH2), 7.25 (5H, m, Ph). EIMS M+ 264, DCIMS+265.
	In ethanol;	a) 2-[(Acetylthio)methyl]-4-phenylbutanoic acid Phenethyl bromide (30 g., 160 mmole) was added, all at once, to a solution of sodium metal (6.5 g., 280 mmole) and diethyl malonate (45 g., 280 mmole) in absolute ethanol (90 ml.). After stirring for 30 minutes at room temperature, a white precipitate formed and the reaction temperature rose to 40. Stirring was continued overnight, then the mixture was heated at reflux for 6 hours. The solvent was removed in vacuo and the residue was partitioned between water (250 ml.) and ether (3 x 200 ml.). The organic extracts were combined, washed with brine, and dried (MgSO4). Removal of the ether in vacuo yielded an amber colored, viscous residue (46.2 g.). This material was distilled and the fraction boiling at 161 - 163/5 mm Hg. was collected to give 19.5 g. of diethyl(phenylethyl)malonate.

General procedure: Sodium (1.0 equiv) is slowly added and dissolved in abs. ethanol (1.4mL/mmol). Then, diethyl malonate (1.0 equiv) is added dropwise and the resulting mixture is stirred during 30 min at room temperature. Then, the respective bromide is added dropwise at room temperature and the resulting mixture is refluxed during 24 h. After removal of volatiles, H2O is added and extractions with Et2O (×3) are performed. The combined organic layers are dried with Na2SO4 and evaporated to afford the crude product which is assumed to contain only the target monoalkylated diethyl ester of type 6. The residue is dissolved in EtOH (0.5 mL/mmol of 6) and cooled at 0C. At the same temperature, a solution of KOH (2.0 equiv) in EtOH (1.5 mL/mmol of 6) is slowly added. The mixture is stirred at rt and the progress of the reaction is followed by TLC, until diethylester 6 is fully consumed (if needed, up to 1.0 equiv of KOH is gradually added). Typically, reaction time is 24h. The mixture is concentrated and the residue is diluted H2O and Et2O. The aqueous phase is separated, washed with Et2O (×2), acidified with HCl 2M to pH ~1 and extracted with AcOEt (×3). The combined organic layers are dried over Na2SO4 and evaporated to afford diacid of type 7. The latter is dissolved/suspended to ΑcOEt (1.8 mL/mmol of 7) and Et2NH (1.2 equiv) is added slowly at 0 C. The temperature is raised at rt, ΗCHO (1.4 equiv) is added and the mixture is refluxed for 4 h. Then, the mixture is concentrated, treated with aq. NaHCO3 5% and washed with Et2O (×3). The aqueous phase is acidified with HCl 2M to pH ~1 and extracted with AcOEt (×3). The combined organic layers are dried over Na2SO4 and evaporated to afford acrylic acid of type 3 inadequately pure form to be used in the P-Michael reaction without further purification.

References: [1]Journal of Medicinal Chemistry,1984,vol. 27,p. 967 - 978.
[2]Heterocycles,2000,vol. 53,p. 1317 - 1328.
[3]Patent: US5629343,1997,A .
[4]Patent: US6048852,2000,A .
[5]Journal of Organic Chemistry,2018,vol. 83,p. 5816 - 5824.
[6]Journal of Medicinal Chemistry,2004,vol. 47,p. 3282 - 3294.
[7]Journal of Medicinal Chemistry,2011,vol. 54,p. 5769 - 5785.
[8]Canadian Journal of Chemistry,1979,vol. 57,p. 1025 - 1032.
[9]Journal of Medicinal Chemistry,1999,vol. 42,p. 2610 - 2620.
[10]Journal of Medicinal Chemistry,2002,vol. 45,p. 3639 - 3648.
[11]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 113 - 121.
[12]Journal of Medicinal Chemistry,2001,vol. 44,p. 4170 - 4175.
[13]Patent: EP361365,1990,A1 .
[14]Journal of Medicinal Chemistry,2019,vol. 62,p. 1917 - 1931.
[15]Journal of the American Chemical Society,2020,vol. 142,p. 20942 - 20947.
[16]Molecules,2022,vol. 27.
[17]Chemical Communications,2022,vol. 58,p. 1135 - 1138.

23
[ 6628-68-8 ]
[ 623-91-6 ]
[ 114278-80-7 ]

References: [1]Monatshefte fur Chemie,1961,vol. 92,p. 51 - 71.

24
[ 100-42-5 ]
[ 14064-10-9 ]
[ 6628-68-8 ]

References: [1]Journal of Organic Chemistry,1990,vol. 55,p. 5688 - 5691.

25
[ 100-42-5 ]
[ 6628-68-8 ]
2-Oxo-3-phenethyl-5-phenyl-tetrahydro-furan-3-carboxylic acid ethyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,1991,vol. 56,p. 5328 - 5335.

26
[ 67-56-1 ]
[ 50-00-0 ]
[ 6628-68-8 ]
[ 113592-34-0 ]

References: [1]Chemische Berichte,1990,vol. 123,p. 875 - 879.

27
[ 934-32-7 ]
[ 6628-68-8 ]
4-hydroxy-3-(2'-phenylethyl)pyrimido-<1,2-a> benzimidazole-2-one [ No CAS ]

References: [1]Arzneimittel-Forschung/Drug Research,1983,vol. 33,p. 1517 - 1518.

28
[ 14396-64-6 ]
[ 6628-68-8 ]
Ethyl 6-bromo-2-carbethoxy-4,5-epoxy-2-(2-phenylethyl)-hexanoate [ No CAS ]

References: [1]Tetrahedron,1993,vol. 49,p. 3841 - 3848.

29
[ 6628-68-8 ]
Mangantriacetat [ No CAS ]
[ 118598-71-3 ]
[ 118629-54-2 ]
[ 118598-64-4 ]
[ 115860-31-6 ]

References: [1]Journal of Organic Chemistry,1989,vol. 54,p. 2713 - 2718.

30
[ 6628-68-8 ]
[ 122086-34-4 ]
[ 115860-31-6 ]

References: [1]Tetrahedron Letters,1989,vol. 30,p. 1289 - 1292.

31
[ 6628-68-8 ]
[ 118598-71-3 ]
[ 118629-54-2 ]
[ 118598-64-4 ]
[ 115860-31-6 ]

References: [1]Journal of Organic Chemistry,1989,vol. 54,p. 2713 - 2718.

32
[ 6628-68-8 ]
[ 85969-94-4 ]

References: [1]Tetrahedron Letters,1983,vol. 24,p. 163 - 166.

33
[ 6628-68-8 ]
[ 118598-70-2 ]
[ 115860-31-6 ]
2-Nitro-2-phenethyl-malonic acid diethyl ester [ No CAS ]

References: [1]Archiv der Pharmazie,1994,vol. 327,p. 515 - 523.
[2]Archiv der Pharmazie,1994,vol. 327,p. 515 - 523.
[3]Archiv der Pharmazie,1994,vol. 327,p. 515 - 523.

34
[ 6628-68-8 ]
[ 64-19-7 ]
[ 122086-34-4 ]
[ 115860-31-6 ]
2-Nitro-2-phenethyl-malonic acid diethyl ester [ No CAS ]

References: [1]Archiv der Pharmazie,1994,vol. 327,p. 515 - 523.

35
[ 50-00-0 ]
[ 6628-68-8 ]
[ 27356-87-2 ]

References: [1]Bulletin de la Societe Chimique de France,1970,p. 219 - 230.

Historical Records

Technical Information

• Acyl Group Substitution • Bouveault-Blanc Reduction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Ester Cleavage • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Specialized Acylation Reagents-Carbodiimides and Related Reagents

Related Functional Groups of
[ 6628-68-8 ]

Aryls

A286123 [5447-69-8]

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Esters

A170842 [37556-02-8]

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A101604 [597-55-7]

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A588001 [2985-39-9]

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 6628-68-8

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