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Chemical Structure| 663925-96-0 Chemical Structure| 663925-96-0

Structure of 663925-96-0

Chemical Structure| 663925-96-0

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Product Details of [ 663925-96-0 ]

CAS No. :663925-96-0
Formula : C16H20ClNO3S
M.W : 341.85
SMILES Code : ClCC(C1=C(SC(OC(C)C)=N2)C2=C(OC(C)(C)C)C=C1)=O
MDL No. :MFCD22690466

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 663925-96-0 ]

[ 663925-96-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67442-07-3 ]
  • [ 1414360-77-2 ]
  • [ 663925-96-0 ]
YieldReaction ConditionsOperation in experiment
Example 10l-(4-teri-butoxy-2-isopropoxy-l,3-benzothiazol-7- l)-2-chloro-ethanoneA solution of n-butyllithium in hexanes (1.6 M, 0.41 mL, 0.65 mmoles) was added dropwise to a pre-cooled (-50 °C) solution of 7-bromo-4-tert-butoxy-2-isopropoxy-l,3-benzothiazole XVII (225 mg, 0.59 mmoles) in methyl tert-butyl ether (2.5 mL) maintaining a temperature below -45 °C. The mixture was allowed to warm to -20 °C and left to stir for 30 minutes. A solution of 2-chloro-N-methoxy-N-methyl acetamide (122 mg, 0.89 mmoles) in methyl tert- butyl ether (2.5 mL) was then added dropwise maintaining a temperature below -15 °C and the mixture allowed to stir for 20 minutes. The reaction was then quenched by the addition of saturated ammonium chloride solution (2.0 mL) and water (10.0 mL). The aqueous phase was extracted with methyl fert-butyl ether (2 x 10 mL) and the combined organic phases were dried (MgSC^), filtered and evaporated to give a pale orange solid. Purification by flash chromatography (isohexane/EtOAc, 95/5 to 90/10) gave title compound XVI as a beige solid (120 mg, 0.35 mmoles).1H NMR (500 MHz, CDC13) delta 7.75 (d, J= 8.5 Hz, 1H), 7.11 (d, J= 8.5 Hz, 1H), 5.46 (hept, J= 6.2 Hz, 1H), 4.79 (s, 2H), 1.50 (s, 9H), 1.47 (d, J= 6.2 Hz, 6H).
  • 2
  • [ 663925-82-4 ]
  • [ 67442-07-3 ]
  • [ 663925-96-0 ]
 

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