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Chemical Structure| 66653-93-8 Chemical Structure| 66653-93-8

Structure of 66653-93-8

Chemical Structure| 66653-93-8

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Product Details of [ 66653-93-8 ]

CAS No. :66653-93-8
Formula : C9H6ClNO2
M.W : 195.60
SMILES Code : O=C1N(C)C(C2=C1C=CC=C2Cl)=O
MDL No. :MFCD30290740

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Application In Synthesis of [ 66653-93-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66653-93-8 ]

[ 66653-93-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 117-21-5 ]
  • [ 74-89-5 ]
  • [ 66653-93-8 ]
YieldReaction ConditionsOperation in experiment
82.5% With glacial acetic acid; In water monomer; toluene; at 50℃; (1) Add 300.0g of <strong>[117-21-5]3-chlorophthalic anhydride</strong> (1.64mol), 600mL of acetic acid and 600mL of toluene to the reaction bottle, and then heat up to 50±5 C, add 250.0g, 40wt% of the aqueous solution of monomethylamine (3.23mol) to the reaction bottle, drip heating to reflux water separation reaction, HPLC monitoring reaction completely.After the end of the reaction, the solvent was concentrated and recovered, and then 200mL of toluene was added to dissolve, cooled and crystallized, filtered, dried to give N-methyl-3-chlorophthalimide 265.0g, purity of 99.2%, yield of 82.5%.
(1) <strong>[117-21-5]3-chlorophthalic anhydride</strong> was placed in a reaction vessel, and <strong>[117-21-5]3-chlorophthalic anhydride</strong> and acetic anhydrideAdd 13ml: 45ml ratio, add acetic anhydride, stirring at 50 for 30min, to 3-chlorinated phthalic anhydride completely dissolved, will<strong>[117-21-5]3-chlorophthalic anhydride</strong> and methylamine aqueous solution in accordance with the 13g: 9ml ratio, then add the mass fraction of 30% methylamine water solubleLiquid, heated to reflux, toluene with water reaction 3.5-5h, then cooled to room temperature and cooled to below 10 with ice water,Filter, dry, that product A
 

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