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Chemical Structure| 672883-68-0 Chemical Structure| 672883-68-0

Structure of 672883-68-0

Chemical Structure| 672883-68-0

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Product Details of [ 672883-68-0 ]

CAS No. :672883-68-0
Formula : C12H11ClF2O3
M.W : 276.66
SMILES Code : O=C(Cl)C1=CC=C(OC(F)F)C(OCC2CC2)=C1

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Application In Synthesis of [ 672883-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 672883-68-0 ]

[ 672883-68-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 672883-68-0 ]
  • [ 6294-52-6 ]
  • 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.72 g With potassium carbonate; In benzene; for 6h;Reflux; 4.1.1.4 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)benzamide 4d Obtained from the reaction of 2d with 3, yellow solid, yield 82% (072?gm), mp 155-156?C. 1HNMR (400?MHz, DMSO-d6) delta 9.97 (s, 1H, NH exchanged with D2O), 7.72 (s, 1H, Ar H), 7.62 (d, J?=?1.8, 8.2, 1H, Ar H), 7.40 (s, 1H, Ar H), 7.31 (d, J?=?1.8, 1H, Ar H), 7.22 (d, J?=?8.2, 1H, Ar H), 7.02 (s, 1H, CHF2), 3.98 (d, J?=?6.92, 2H, CH2), 3.81 (s, 3H, OCH3), 3.76 (s, 3H, OCH3), 1.30 (m, 1H, CH), 0.61 (m, 2H, 2 CH), 0.38 (m, 2H, 2 CH). 13C NMR (100?MHz, DMSO-d6) delta 164.80, 149.97, 148.64, 148.45, 142.84, 132.44, 129.51, 120.94, 119.56, 116.99, 115.45, 114.42, 114.03, 113.10, 111.59, 73.72, 56.50, 56.31, 10.43, 3.52. IR (KBr) upsilonmax?cm-1: 3259 (NH), 1647 (C=O). Elemental analysis calcd (%) for C21H20F2N2O5S (450.46): C, 55.99; H, 4.48; N, 6.22. Found: C, 56.23; H, 4.62; N, 6.39.
  • 2
  • [ 672883-68-0 ]
  • [ 777-12-8 ]
  • 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.64 g With potassium carbonate; In benzene; for 6h;Reflux; 4.1.1.8 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)benzamide 4h Obtained from the reaction of 2h with 3, white solid, yield 72percent (0.64?gm), mp 160-161?°C. 1HNMR (400?MHz, DMSO-d6) delta 10.34 (s, 1H, NH exchanged with D2O), 7.74 (m, 1H, Ar H), 7.54 (m, 1H, Ar H), 7.39 (s, 1H, CHF2), 7.26 (d, J?=?8.16, 1H, Ar H), 7.19 (d, J?=?8.48, 1H, Ar H), 3.93 (d, J?=?6.92, 2H, CH2), 1.23 (m, 1H, CH), 0.55 (m, 2H, 2 CH), 0.36 (m, 2H, 2 CH). 13C NMR (100?MHz, DMSO-d6) delta 170.53, 166.92, 149.86, 143.82, 133.98, 130.29, 129.11, 128.75, 126.10, 124.84, 122.75, 120.56, 119.44, 116.88, 115.18, 114.31, 73.58, 10.36, 3.48. IR (KBr) upsilonmax?cm-1: 3294 (NH), 1654 (C=O). Elemental analysis calcd (percent) for C20H15F5N2O3S (458.40): C, 52.40; H, 3.30; N, 6.11. Found: C, 552.67; H, 3.67; N, 6.39.
 

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