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Chemical Structure| 676494-70-5 Chemical Structure| 676494-70-5

Structure of 676494-70-5

Chemical Structure| 676494-70-5

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Product Details of [ 676494-70-5 ]

CAS No. :676494-70-5
Formula : C13H10N2O3
M.W : 242.23
SMILES Code : O=C(C1=CC=C(OC2=CC=C(C=O)C=C2)N=C1)N
MDL No. :MFCD30549207

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Application In Synthesis of [ 676494-70-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 676494-70-5 ]

[ 676494-70-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 676494-70-5 ]
  • [ 64090-19-3 ]
  • [ 676495-63-9 ]
YieldReaction ConditionsOperation in experiment
21% Combine 6- (4-formyl-phenoxy)-nicotinamide (compound of example 332, step 1) (0.299 g, 1.23 mmol), 1- (4-fluoro-phenyl)-piperizine, bis hydrochloride salt (0.314 g, 1. 24 MMOL), TRIETHYLAMINE (0.36 mL, 2.58 mmol) in methanol (12 mL) and stir. After 23 h, add sodium borohydride (0.108 g, 2.85 mmol). After 1 d, concentrate and purify the residue by silica gel chromatography (25 : E 4: 1 methylene chloride: methanol) to provide 0.107 g (21 %) of the title compound as a white solid: high resolution mass spectrum (electrospray): m/z calc for C23H24FN402 407.1883, found 407.1883 ; 1H NMR (methanol-d4) : 8.67 (d, 1H, J= 2. 4 HZ), 8.30 (dd, 1H, J= 2. 4 ; 8.8 HA 7. 52-7.47 (m, 2H), 7.20-7.15 (m, 2H), 7.05 (d, 1H, J = 7.8 Hz), 7.01 (d, 4H, J= 6.3 Hz), 3.66 (s, 2H), 3.21-3. 16 (M, 4H), 2.74-2. 68 (m, 4H).
 

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• Acyl Group Substitution • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Julia-Kocienski Olefination • Knoevenagel Condensation • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nomenclature of Ethers • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Ethers • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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