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Chemical Structure| 6814-68-2 Chemical Structure| 6814-68-2

Structure of 6814-68-2

Chemical Structure| 6814-68-2

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Product Details of [ 6814-68-2 ]

CAS No. :6814-68-2
Formula : C9H11N3
M.W : 161.20
SMILES Code : NCCC1=NNC2=C1C=CC=C2
MDL No. :MFCD08450479

Safety of [ 6814-68-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 6814-68-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6814-68-2 ]

[ 6814-68-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20806-43-3 ]
  • [ 6814-68-2 ]
  • (S)-benzyl (1-((2-(1H-indazol-3-yl)ethyl)amino)-3-(benzyloxy)-1-oxopropan-2-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at -10℃; for 1h; A solution of 2-(lH-indazol-3-yl)ethanamine (240 mg, 1.49 mmol), (
75% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at -10℃; for 1h; A solution of 2-( 1H-indazol-3 -yl)ethanamine (240 mg, 1.49 mmol), (S)-3 -(benzyloxy)-2- (((benzyloxy)carbonyl)amino)propanoic acid (981 mg, 2.98 mmol) and diisopropylethylamine (578 mg, 4.47 mmol) in N,N-dimethylformamide (20 mL) was cooled to -10 C and treated with O-(7-azabbenzotriazol-1-yl)-N,N,N?,N?- tetramethyluronium hexafluorophosphate (1.70 g, 4.47 mmol). The mixture was stirred at -10 C for 1 h. After this time, the reaction mixture was treated with water (40 mL) and extracted with ethyl acetate (2 * 40 mL). The combined organics were washed with saturated aqueous sodium bicarbonate (40 mL), water (40 mL), and brine (40 mL); dried over sodium sulfate; filtered; and concentrated under reduced pressure. The residue was purified by column chromatography (40 g silica column, 0-100% ethyl acetate/heptane) to provide (S)-benzyl (l-((2-(lH-indazol-3- yl)ethyl)amino)-3-(benzyloxy)-l-oxopropan-2-yl)carbamate (535 mg, 75%) as a white solid: ESI MS m/z 473 [C27H28N4O4 + H]+.
 

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