6845-81-4|2-(Benzo[d][1,3]dioxol-5-yl)acetyl chloride| Ambeed

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CAS No. :	6845-81-4
Formula :	C₉H₇ClO₃
M.W :	198.60
SMILES Code :	O=C(Cl)CC1=CC=C(OCO2)C2=C1
MDL No. :	MFCD03424722

Yield	Reaction Conditions	Operation in experiment
80%	In pyridine; dichloromethane; at 120℃; for 0.0833333h;Microwave irradiation;	2-(2-benzo[1 ,31dioxol-5-yl-acetylamino)-4,6-difluoro-benzoic acid (V) To a solution of commercially available benzo[1 ,3]dioxol-5-yl-acetyl chloride (3.70 g, 18.70 mmol) in anhydrous dichloromethane (20 mL) was added <strong>[126674-77-9]2-amino-4,6-difluoro-benzoic acid</strong> (2.20 g, 12.5 mmol). After the addition of pyridine (5 mL), the mixture was heated under microwave condition at 120C for 5 minutes. The solvent was evaporated and the residue was diluted with 2 N HCI solution to induce the precipitation of a brown solid which was filtered, washed with water and dried under vacuum at 50C, to afford the title compound (3.34 g, 80% yield).1 H-NMR (400 MHz), delta (ppm, DMSO-cie): 12.21 (bs, 1 H), 10.65 (bs, 1 H), 7.93 (m, 1 H), 7.07 (m, 1 H), 6.90 (d, 1 H), 6.88 (d, 1 H), 6.80 (dd, 1 H), 5.99 (s, 2 H), 3.66 (bs, 2 H).
80%	With pyridine; In dichloromethane; at 120℃; for 0.0833333h;Microwave irradiation;	Step 22-(2-benzo[1,3]dioxol-5-yl-acetylamino)-4,6-difluoro-benzoic acid (V)To a solution of commercially available benzo[1,3]dioxol-5-yl-acetyl chloride (3.70 g, 18.70 mmol) in anhydrous dichloromethane (20 mL) was added <strong>[126674-77-9]2-amino-4,6-difluoro-benzoic acid</strong> (2.20 g, 12.5 mmol). After the addition of pyridine (5 mL), the mixture was heated under microwave condition at 120 C. for 5 minutes. The solvent was evaporated and the residue was diluted with 2 N HCl solution to induce the precipitation of a brown solid which was filtered, washed with water and dried under vacuum at 50 C., to afford the title compound (3.34 g, 80% yield).1H-NMR (400 MHz), delta (ppm, DMSO-d6): 12.21 (bs, 1H), 10.65 (bs, 1H), 7.93 (m, 1H), 7.07 (m, 1H), 6.90 (d, 1H), 6.88 (d, 1H), 6.80 (dd, 1H), 5.99 (s, 2H), 3.66 (bs, 2H).
	With pyridine; In dichloromethane; at 120℃; for 0.0833333h;Microwave irradiation;	General procedure: To a solution of acyl chlorides (18.70 mmol) in anhydrous dichloromethane (20 mL) was added 2-amino-benzoic acid derivatives 4 (12.5 mmol). After the addition of pyridine (5 mL), the mixture was heated under microwave condition at 120 C for 5 min. The solvent was evaporated and the residue was diluted with 2 N HCl solution to induce the precipitation of a brown solid which was filtered, washed with water and dried under vacuum at 50 C, to afford the 2-acylamine-benzoic acids 5. A stirred solution of compounds 5 (25 mmol) in acetic anhydride (50 mL) was refluxed for 10 min. The solvent was removed in vacuum and the residue was taken up in diethyl ether, to provide after filtration and drying the title benzoxazin-4-ones 6. A solution of benzoxazin-4-ones 6 (20.2 mmol) and aminoguanidine hydrogencarbonate (20.2 mmol) in pyridine (25 mL) was heated under microwave condition at 180 C for 30 min. The reaction was cooled at room temperature and diluted with methanol/water 1:1 to induce the precipitation of a brown solid which was washed with a mixture MeOH/H2O 8:2, to afford the desired compounds

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Prevention
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Response
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P320
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P321
P322
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P378
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P391	Collect spillage. Hazardous to the aquatic environment
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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P370 + P378	In case of fire:
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P401
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Disposal
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 6845-81-4

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CAS No.: 6845-81-4

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