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Chemical Structure| 690631-99-3 Chemical Structure| 690631-99-3

Structure of 690631-99-3

Chemical Structure| 690631-99-3

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Product Details of [ 690631-99-3 ]

CAS No. :690631-99-3
Formula : C11H16N2O
M.W : 192.26
SMILES Code : OCC1=CC=C(N2CCCCC2)N=C1
MDL No. :MFCD05865147

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Application In Synthesis of [ 690631-99-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 690631-99-3 ]

[ 690631-99-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 690631-99-3 ]
  • [ 93247-78-0 ]
  • [ 1196047-33-2 ]
YieldReaction ConditionsOperation in experiment
Production Example 55 To (6-piperidin-1-ylpyridin-3-yl)methanol (0.61 g) was added methylene chloride (6.0 mL), and thionyl chloride (1.0 mL) was added dropwise thereto under ice-cooling. In addition, a catalytic amount of DMF was added thereto, followed by stirring at room temperature for 2 hours. Methylene chloride (5.0 mL) and thionyl chloride (1.0 mL) were added thereto, followed by stirring at 60°C overnight. The reaction mixture was concentrated under reduced pressure, and DMF (10 mL) was added thereto. Then, <strong>[93247-78-0]methyl 1H-indole-7-carboxylate</strong> (0.56 g) and potassium tert-butoxide (1.3 g) were added thereto under ice-cooling, followed by stirring at room temperature for 3 hours. The reaction mixture was extracted by adding ethyl acetate and water, and the organic layer was washed with brine, dried over anhydrous sodium sulfate, then filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5-70/30) to obtain methyl 1-[(6-piperidin-1-ylpyridin-3-yl)methyl]-1H-indole-7-carboxylate (0.12 g).
 

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