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Chemical Structure| 690632-04-3 Chemical Structure| 690632-04-3

Structure of 690632-04-3

Chemical Structure| 690632-04-3

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Product Details of [ 690632-04-3 ]

CAS No. :690632-04-3
Formula : C13H11NO3S
M.W : 261.30
SMILES Code : O=C(C1=C(C)N=C(C2=CC=C(OCC3)C3=C2)S1)O
MDL No. :MFCD01313483

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Application In Synthesis of [ 690632-04-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 690632-04-3 ]

[ 690632-04-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 690632-04-3 ]
  • [ 170017-74-0 ]
  • [ 1029431-70-6 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 80℃; for 15h; Example 10Preparation of Compound 11To a solution of 2-(2,3-dihydro-benzofuran-5-yl)-4-methyl-thiazole-5- carboxylic acid (0.10 mmol, 26 mg), λ/,λ/-diisopropylethylamine (0.50 mmol, 87 μl_) and HATU (0.10 mmol, 38 mg) in DMF (1 ml_) was added 4-(2-aminophenyl)- piperazine-1 -carboxylic acid te/t-butyl ester (0.10 mmol, 28 mg). The resulting reaction was heated to 80 0C and allowed to stir at this temperature for 15 h, after which time the reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting residue was treated with TFA (0.5 mL) with stirring for 10 minutes, then the TFA solution was concentrated in vacuo. The resulting residue was dissolved in DMSO/ACN (3:1), and purified using reverse phase HPLC to provide Compound 11 as an ammonium salt.
 

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