[ CAS No. 69088-97-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 69088-97-7 * Storage: {[proInfo.prStorage]}

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 69088-97-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 69088-97-7 ]

SDS Specification

Alternatived Products of [ 69088-97-7 ]

Product Details of [ 69088-97-7 ]

CAS No. :	69088-97-7	MDL No. :	N/A
Formula :	C₈H₈O₄S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	200.21	Pubchem ID :	-
Synonyms :

Safety of [ 69088-97-7 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 69088-97-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 69088-97-7 ]
Downstream synthetic route of [ 69088-97-7 ]

[ 69088-97-7 ] Synthesis Path-Upstream 1~4

1
[ 69088-97-7 ]
[ 874-89-5 ]

Reference： [1] Journal of Organic Chemistry, 2018,

2
[ 69088-97-7 ]
[ 73183-34-3 ]
[ 128376-64-7 ]

Reference： [1] Chemistry - A European Journal, 2011, vol. 17, # 25, p. 6913 - 6917

3
[ 1314538-55-0 ]
[ 69088-97-7 ]
[ 156866-52-3 ]

Reference： [1] Organic Letters, 2012, vol. 14, # 12, p. 3138 - 3141

4
[ 69088-97-7 ]
[ 17933-03-8 ]
[ 400744-83-4 ]

Reference： [1] Chemical Communications, 2012, vol. 48, # 14, p. 1967 - 1969

[ 69088-97-7 ] Synthesis Path-Downstream 1~53

1
[ 69088-97-7 ]
[ 28547-25-3 ]

Reference： [1]Journal of the American Chemical Society,1957,vol. 79,p. 745

2
[ 123-08-0 ]
[ 124-63-0 ]
[ 69088-97-7 ]

Yield	Reaction Conditions	Operation in experiment
96%	With triethylamine; In ethyl acetate; at 0 - 20℃; for 0.166667h;Green chemistry;	General procedure: To a solution of hydroxyarene (25.0 mmol) in ethyl acetate (75 mL) at 0 C was added triethylamine (5.06 g, 50.0 mmol) followed by MsCl (3.72 g, 32.5 mmol). After addition of MsCl, the ice-water bath was removed and the resulting thick slurry was vigorously stirred for 10 min. To the slurry was then added water (50 mL). The two-phase mixture was separated. The organic layer was washed with water (25 mL) and dried over anhydrous MgSO4. Removal of solvent under reduced pressure gave the corresponding pure aryl mesylate.
81.23%	With triethylamine; In dichloromethane; at 20℃; for 24h;	General procedure: 4-Hydroxy benzaldehyde (1.14 g, 9.36 mmol) was dissolved in dichloromethane (20 ml) and to this solutiontriethylamine (1.43 ml, 10.30 mmol) was added drop wisewith stirring. Various substituted sulfonyl chlorides (9.36mmol) were added to the mixture and stirred at room temperature for 24 h. The reaction mixture was extractedwith water (3 × 20 ml) and brine (3 × 20 ml) repeatedly for removing triethylamine hydrochloride salt. The organiclayer was dried, solvent removed and the residue wasobtained as solid product.
	With sodium bicarbonate; In pyridine;	Step 1 Methanesulfonic Acid 4-formylphenyl Ester At 0 C., methanesulfonyl chloride (9.51 ml, 0.123 mol) was added to a solution of 4-hydroxybenzaldehyde (15 g, 0.123 mol) in pyridine (12.91 ml, 0.160 mol). The reaction mixture was stirred at 0 C. for 3 h and left at room temperature for 16 h. It was given onto conc. hydrochloric acid/ice (200 ml/200 ml). The mixture was extracted with ethyl acetate (4300 ml). The combined organic layers were washed with a 5% aqueous solution of sodium hydrogen carbonate (3200 ml) and brine (100 ml). They were dried over magnesium sulphate. The solvent was removed in vacuo to give 22.87 g of crude methanesulfonic acid 4-formylphenyl ester, which was used in the next step without further purification. 1H-NMR (CDCl3) delta 13.22 (s, 3 H); 7.45 (d, 2 H); 8.00 (d, 2 H); 10.02 (s, 1 H).

	With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20℃; for 16h;	A mixture of 4-hydroxybenzaldehyde (5.0 gm, 1.0 eq, 40.98 mmol), anhydrous K2CO3 (17 g, 3 eq, 123 mmol), and methanesulfonylchloride (4.76 mL, 1.5 eq, 61.37 mmol) in dry DMF (200 mL) was stirred at RT for 16 h. The reaction mixture was diluted with ethyl acetate (200 mL) and washed with water and brine. Organic layer was dried (Na2SO4), condensed, and the residue obtained was chromatographed using ethyl acetate and hexanes to obtain the title compound as white solid (2.0 g, 25%). Mp: 60-62 C. [0236] 1H NMR (CDCl3, 200 MHz) delta: 3.21 (s, 3H); 7.45 (d, J=8.8 Hz, 2H); 7.95 (d, J=8.8 Hz, 2H); 10.01 (s, 1H). [0237] IR (neat) cm-1: 3024, 2932, 1701, 1591, 1502. [0238] Mass m/z (CI): 201 [M+1].
	With triethylamine; In ethyl acetate; at 0 - 20℃; for 1h;	In a round bottom flask, aldehyde phenol (1.22 g, 10 mmol) was dissolved in 30 mL of ethyl acetate, and Et3N (2.8 mL, 20 mmol), MsCl (1.0 mL, 13 mmol) was added at 0 C, and the ice water bath was removed after the addition. The reaction was carried out at room temperature, and the reaction was confirmed by TLC. The reaction was quenched with addition of water, extracted with ethyl acetate, the organic phase washed with water, wash with saturated brine, dry over anhydrous magnesium sulfate, filtered over silica gel. After the filtrate was concentrated, the next reaction was carried out.

Reference： [1]Helvetica Chimica Acta,1991,vol. 74,p. 654 - 661
[2]Synthesis,2015,vol. 47,p. 2578 - 2585
[3]Journal of the Chemical Society. Perkin transactions I,1980,vol. 1,p. 31 - 42
[4]Medicinal Chemistry Research,2018,vol. 27,p. 476 - 487
[5]Chemical and Pharmaceutical Bulletin,2002,vol. 50,p. 1634 - 1637
[6]Journal of the American Chemical Society,1957,vol. 79,p. 745
[7]Journal of Organic Chemistry,1979,vol. 44,p. 1166 - 1168
[8]Patent: US2003/195190,2003,A1
[9]Patent: US2003/229083,2003,A1 .Location in patent: Page 22
[10]Journal of Organic Chemistry,2010,vol. 75,p. 8571 - 8577
[11]Chemistry - A European Journal,2011,vol. 17,p. 6913 - 6917
[12]Journal of Organic Chemistry,2018,vol. 83,p. 14036 - 14048
[13]Patent: CN110117237,2019,A .Location in patent: Paragraph 0120-0122

3
[ 141-82-2 ]
[ 69088-97-7 ]
[ 69088-98-8 ]

Reference： [1]Helvetica Chimica Acta,1991,vol. 74,p. 654 - 661
[2]Journal of Organic Chemistry,1979,vol. 44,p. 1166 - 1168

4
[ 69088-97-7 ]
[ 4999-89-7 ]

Yield	Reaction Conditions	Operation in experiment
1.899 g	With sodium tetrahydroborate; In methanol; dichloromethane; at 20℃;	The product of the above step was dissolved in 20 mL of MeOH and 20 mL of DCM, and NaBH4 (491.8 mg, 13 mmol) was added portionwise. After the addition, the reaction was carried out at room temperature, and the reaction was confirmed by TLC. The reaction was quenched by the addition of saturated ammonium chloride and extracted with DCM. The organic phase is washed with water, washed with saturated brine, dried over anhydrous sodium sulfate, filtration and concentration, silica gel column chromatography, eluent: petroleum ether / ethyl acetate = 4:1, to give a colorless liquid 1.89 g, yield 95%.

Reference： [1]European Journal of Organic Chemistry,2017,vol. 2017,p. 4972 - 4983
[2]Journal of the Chemical Society. Perkin transactions I,1980,vol. 1,p. 31 - 42
[3]Journal of Organic Chemistry,2018,vol. 83,p. 14036 - 14048
[4]Patent: CN110117237,2019,A .Location in patent: Paragraph 0120-0121; 0123

5
[ 1076-38-6 ]
[ 69088-97-7 ]
3,3'-[4-[(methylsulfonyl)oxy]benzylidene]bis(4-hydroxy-coumarin) [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,2002,vol. 50,p. 1634 - 1637

6
[ 69088-97-7 ]
methanesulfonic acid 4-(hydroxyimino-methyl)-phenyl ester [ No CAS ]

Reference： [1]Synthesis,2003,p. 1018 - 1024

7
[ 35023-80-4 ]
[ 69088-97-7 ]
[ 849441-36-7 ]