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CAS No. : | 693-38-9 | MDL No. : | MFCD00059288 |
Formula : | C18H34O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UJRIYYLGNDXVTA-UHFFFAOYSA-N |
M.W : | 282.46 | Pubchem ID : | 69658 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Thermomyces lanuginosus lipase; In 2-methyltetrahydrofuran; at 60℃;Green chemistry; Enzymatic reaction; | General procedure: The acylation was carried out in a 10 mL Erlenmeyer shakingflask with an anhydrous 2-MeTHF (3 mL) containing 0.03 mmol<strong>[27208-80-6]polydatin</strong> and 0.27 mmol vinyl donors. The reactants were wellblended in an air-bath shaker with orbital stirring (200 rpm),and enzyme (5.5 U) was followed when the reaction temperaturereached the desired level. Aliquot fractions of reaction mixturewere periodically withdrawn during the reaction process and ana-lyzed by HPLC. Each acylation experiment was performed at leastin triplicate and the results were based on the average values. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With Novozym 435; In acetonitrile; at 20℃; for 3h;Inert atmosphere; Enzymatic reaction; | General procedure: To a suspension of (-)-<strong>[56-75-7]chloramphenicol</strong> (1, 100 mg, 0.301 mmol) and the corresponding enzyme (CAL-B or PSL, ratio 1:1 in weight respecting 1) in dry solvent (MeCN or 1,4-dioxane, 2.0 mL), the corresponding vinyl ester 3a-f (5 equiv., 1.505 mmol) was added under nitrogen atmosphere. The reaction was shaken at 20 or 30 C and 250 rpm, and aliquots were regularly analysed by HPLC. The reaction was stopped after complete consumption of the starting material, and then the enzyme was filtered off and washed with EtOAc (3 x 10 mL). Finally the solvent was evaporated under reduced pressure, and the reaction crude purified by flash chromatography on silica gel using mixtures of EtOAc/hexane to afford the desired ester (2'R,3'R)-2a-f. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96.5% | With sodium methylate at 60℃; for 1.5h; Neat (no solvent); | |
With sodium methylate at 60℃; for 1.5h; | 2 Synthesis of N-stearoylethanolamine Using Vinyl Stearate Based on Procedures Described for Other Acyl Donors The yields of N-stearoyl and N-palmitoylethanolamines were studied as a function of varying one of four variables while keeping the other three variables constant: sodium methoxide concentration, molar ratio of ethanolamine to fatty acid vinyl ester, reaction temperature and time. [0078] To determine the catalyst concentration, ethanolamine (20 mmol) and vinyl stearate or palmitate (1 mmol) were mixed at 60° C. for 1 hour with different concentrations of sodium methoxide (0.5-4% for the synthesis of N-stearoylethanolamine, 1-4% for N-palmitoylethanolamine). [0079] To determine the reactant ratio, different quantities of ethanolamine (5-25 mmol) were reacted with 1 mmol fatty acid vinyl ester at 60° C. for 1 hour. Sodium methoxide at 1% was used to determine the molar ratio of ethanolamine to vinyl stearate, while 3% sodium methoxide was used to determine the molar ratio of ethanolamine to vinyl palmitate as these catalyst concentrations were confirmed to be better concentrations for the two reactions. [0080] After 20:1 molar ratio was confirmed as the optimal ratio for the synthesis, ethanolamine (20 mmol) and vinyl stearate or palmitate (1 mmol) were mixed at different temperatures (40-80° C.) for 1 hour with 1% or 3% sodium methoxide to determine the reaction temperature. [0081] Moreover, ethanolamine (20 mmol) and vinyl stearate (1 mmol) were mixed at 80° C. with 1% sodium methoxide to determine the reaction time, as 80° C. was chosen as a better reaction temperature. The same ratio of reactants was mixed at 60° C. with 3% sodium methoxide to determine the reaction time for the N-palmitoylethanolamine synthesis. [0082] For all the products, the excess ethanolamine was removed from the product by addition of distilled water (5 mL) and crystallization of the amide at 6° C. for one hour. N-acylethanolamines were washed three more times with water. All the above experiments were conducted in duplicate. | |
With potassium methanolate In methanol at 65℃; for 3h; | 4 In the reaction kettle adding 1mmol palmitic acid vinyl ester and 25mmol mono-ethanolamine, adding the substrate of reaction mass percentage of 2% of potassium methoxide methanol solution (30% wt) as catalyst, in the 65 °C, reaction under the condition of 300 rpm 3h. For 6 °C distilled water wash off the excess of the mono-ethanolamine. The use of mixed solvent (hexane: isopropanol=1:1, v/v) the reaction product dissolved and diluted to a suitable concentration, by HPLC-ELSD analysis, palmitic acid monoethanolamide content is 97.38%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With 2,2-dimethoxy-2-phenylacetophenone; In dichloromethane;UV-irradiation; | Fmoc-Cys(Trt)-OH 1.3 (2.1 g) was treated with a solution of TFA/DCM (v/v, 1 : 1, 15 mL) at room temperature for 3 h. The TFA solution was then concentrated under a stream of N2, diluted with FhO/MeCN (1: 1, 30 mL) containing 0.1% TFA, and lyophilised yielding a white amorphous solid 1.4 (2060 mg, 59%); m/z (ESI-MS) 344.1 ([M+H]+ requires 344.1). The solid (500 mg, 1.39 mmol) was dissolved in DCM (5 mL) with vinyl palmitate 1.2 (615 mg, 2.18 mmol) and DMPA (374 mg, 1.45 mmol) and the solution was irradiated under UV light (365 nm) until TLC confirmed complete consumption of the starting material; Fmoc-Cys-OH 1.4. The solvent was evaporated in vacuo and the crude reaction mixture purified by flash column chromatography (petroleum ether/EtOAc, 3:2; followed by MeOH/DCM, 5:95), and the resulting yellow oil was lyophilised to afford the title compound 1.1 as a pale yellow solid (255 mg, 86% yield); m/z (ESI-MS) 626.4 ([M+H]+ requires 646.4). [ ]2^ - 7.4 (c 0.012 in CHCb) (lit. {Eur. J. Org. Chem. 2016, 2608-2616) - 8.5 c 0.398, MeOH). NMR (400 MHz; CDCb): deltaEta = 7.76 (d, / = 7.5 Hz, 2H, 2 x Ar- H), 7.60 (d, / = 6.6 Hz, 2H, 2 x Ar-H), 7.39 (t, / = 7.4 Hz, 2H, 2 x Ar-H), 7.31 (m, 2H, 2 x Ar-H), 5.73 (d, / = 7.7 Hz, 1H, N-H), 4.66-4.65 (m, 1H, a-CH), 4.44-4.41 (m, 2H, Fmoc- CH2), 4.24-4.20 (m, 3H, Fmoc-CH and H-4), 3.14 (dd, / = 13.5, / = 4.5, 6.8 Hz, 1H, beta- CH2a), 3.07 (dd, / = 14.2, / = 5.3, 1Eta, beta-0), 2.78 (t, / = 6.1 Hz, 2H, H-5), 2.29 (t, / = 15.2, 2H, H-5), 1.58 (m, 2H, H-6), 1.31-1.24 (m, 26H), 0.88 (t, / = 5.6, 3H, H-7) ppm. 13C NMR (100 MHz; CDCb): 5c = 174.9 (C, C=0), 174.0 (C, C=0), 155.1 (C, OCONH), 143.8 (CH, ArCH), 143.8 (CH, ArCH), 141.4 (CH, ArCH), 127.9 (CH, ArCH), 127.1 (CH, ArCH), 120.1 (CH, ArCH), 67.5 (CH2, Fmoc-CH2), 63.2 (CH2, -CH2), 53.7 (CH, a-CH), 47.2 (CH, Fmoc-CH), 34.5 (CH2, beta-Omicron2), 34.3 (CH2, C-5), 32.1 (CH2), 31.4 (CH2, C-3), 29.7 (CH2), 29.6 (CH2), 29.5 (CH2), 29.4 (CH2), 29.3 (CH2), 25.0 (CH2), 22.8 (CH2), 14.2 (CH3, C-7) ppm. (0776) Spectroscopic data and optical rotation were in good agreement with those previously reported in Eur. J. Org. Chem. 2016, 2608-2616. |
13% | With 2,2-dimethoxy-2-phenylacetophenone; In dichloromethane; N,N-dimethyl-formamide; for 6h;UV-irradiation; | Fmoc-Cys-OH (100 mg, 0.29 mmol) is dissolved in degassed, anhydrous DMF (500 mu). Vinyl palmitate (90 mu, 0.3 mmol) and DMPA (5.0 mg, 20 muetaetaomicronIota) are dissolved in degassed CH2CI2 (200 mu). The two solutions are combined and the resultant mixture irradiated for 6 hr (365 nm UV) in a standard photochemical apparatus. When no further change in the reaction mixture can be observed by TLC, solvent is removed under reduced pressure. The crude product is purified by silica gel flash chromatography (3: 1 EtOAc: n-hexanes + 2% AcOH), followed by lyophilization from 1 : 1 H20: MeCN + 0.1% TFA to afford the title compound as a powdery white solid (24 mg, 13%). Structure of the desired product 200 is confirmed by mass spectrometry. |
13% | With 2,2-dimethoxy-2-phenylacetophenone; In dichloromethane; N,N-dimethyl-formamide; for 6h;Inert atmosphere; UV-irradiation; | Fmoc-CysOH (100 mg, 0.29 mmol) was dissolved in degassed anhydrous DMF (500 yL). The palmitic acid was added(90yL, 0.3mmo 1) and DMPA (5.Omg, 20mupiomicron 1) were dissolved in degassed CH2C12 (200yL). The two solutions were mixed and the resulting mixture was irradiated in a standard photochemical apparatus for 6 hours (365 nm UV). When no further change in the reaction mixture was observed by TLC, the solvent was removed at a reduced pressure. The crude product was purified by flash chromatography on silica gel (3: 1 EtOAc: n-hexane + 2% Ac0H) followed by lyophilization from 1: lH20: MeCN + 0.1% TFA to provide the title compound as a powdery white solid (24 mg, 13%) . The structure of the desired product 200 was confirmed by mass spectrometry. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With Candida antarctica Lipase type B; In acetonitrile; at 20℃; for 1h;Inert atmosphere; Enzymatic reaction; | General procedure: To a suspension of (-)-<strong>[15318-45-3]thiamphenicol</strong> (1, 50 mg,0.14 mmol) and CAL-B (50 mg) in dry MeCN (1.4 mL),the corresponding vinyl ester 4a-e (5 eq, 0.70 mmol)was added under nitrogen atmosphere, and the reactionshaken at 20 C and 250 rpm. Aliquots were regularlyanalyzed by HPLC and the reaction stopped whencomplete consumption of the starting material wasobserved (1-3 h, see Table 1). Finally, the enzyme wasfiltered off and washed with EtOAc (3 × 5 mL), the solventevaporated under reduced pressure, and the reaction crudepurified by flash chromatography on silica gel (60%EtOAc/hexane), affording the corresponding monoesters5a (96%), 5b (98%), 5c (94%), 5d (96%) and 5e (98%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With immobilized Candida antarctica Lipase B; In toluene; at 60℃; for 8h;Enzymatic reaction;Catalytic behavior; | The immobilized CALB, Novozyme 435, was purchasedfrom Novozyme. <strong>[127-40-2]Lutein</strong> and <strong>[127-40-2]lutein</strong> dipalmitate were purchasedfrom Sigma-Aldrich. Vinyl palmitate was purchasedfrom TCI Company. Other chemicals were all ofanalytical grade.In a typical experiment, 2 g of vinyl palmitate wasadded to a suspension of 400 mg <strong>[127-40-2]lutein</strong> and 400 mgNovozyme 435 in 20 mL of organic solvents under nitrogenatmosphere. The mixture was then gently shaken at250 rpm for 8 h. Aliquots were regularly taken and analyzedby high performance liquid chromatography (HPLC).After reaction, the enzyme catalyst Novozyme 435 wasfiltered out for repeated use, followed by the purification ofproducts by a column chromatograph, eluted with hexane/AcOEt 3:1. The structure of the product was confirmed byFT-IR and NMR analysis.The yield and purity of <strong>[127-40-2]lutein</strong> dipalmitate were determinedby high performance liquid chromatography usingthe SHIMADSU SPD-10AVP system equipped with aYMC30 column (5 lm, 4.6 9 250 mm) and a UV-Visdetector at 446 nm. For each measurement, 20 lL ofsample was injected and eluted at 1 mL/min with a binarymobile phase consisted of acetonitrile-methanol (3:1, v/v;solvent A) and methyl tert-butyl ether (solvent B). Elutionwas carried out with a gradient program: 100-40 % A in10 min, 40 % A in 10-20 min and 40-100 % A in20-25 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Ru catalyst at 140℃; | 4 Example 4 (0044) Separation of a vinyl palmitate/palmitic acid mixture from a transvinylation reaction by reactive distillation with vinyl acetate Example 4 (0044) Separation of a vinyl palmitate/palmitic acid mixture from a transvinylation reaction by reactive distillation with vinyl acetate (0045) 220 g/h of a mixture of palmitic acid (Carl Roth 5907.2) and catalyst (active Ru catalyst solution based on RuCl3, as disclosed in DE 102014206915, 1000 ppm Ru relative to palmitic acid) and 27.7 l/min of gaseous vinyl acetate were introduced into a 2 l glass reactor equipped with a dip tube. Vinyl acetate and the acetic acid formed were discharged in gaseous form and condensed outside the reactor. The reaction was performed with a constant reactor fill volume of 1750 ml, an average residence time of 6.7 hours and at an internal reactor temperature of 140° C. A mixture composed of 76 wt % vinyl palmitate, 20 wt % palmitic anhydride and 4 wt % palmitic acid was obtained. Removal of the vinyl palmitate was effected via a vacuum distillation at 150° C. (1 mbar abs.). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75%; 10% | With 2,2-dimethoxy-2-phenylacetophenone; In dichloromethane;Irradiation; | Irradiation at 365 nm of a solution of lmL total volume comprised of Fmoc-Cys-OH (3.4 mg, 10 mutauiotaomicronIota), vinyl pa lmitate ( 141 mg, 500 mutauiotaomicronIota) and DMPA (0.5 mg, 2 mutauiotaomicronIota) dissolved in CH2CI2 (approx. 850 muIota_) for 60 minutes afforded a product mixture composed of mono- palmitoylated Fmoc-Cys 5 as the major component and bis-palmitoylated Fmoc-Cys 6 (m/z ESI, 908.5 [M + H]) as the minor component (Scheme 4). After evaporation of the solvent each component could be isolated by column chromatography on silica, eluting firstly with 4: 1 hexa ne/ethyl acetate then switching to 2 : 1 hexane/ethyl acetate a nd fina lly 1 : 1 hexa ne/ethyl acetate. This afforded 5 (4.6 mg, 75%) a nd 6 (0.9 mg, 10%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With Candida antarctica lipase B In 2,2,4-trimethylpentane; acetone at 55℃; for 4.5h; Enzymatic reaction; regioselective reaction; | Enzymatic acylation of nucleoside General procedure: In a typical experiment, 6-azauridine (0.04 mmol), C. antarctica lipase B and vinyl ester were added into 2 mL anhydrous organic solvent and the mixture was incubated at a predetermined temperature in an orbital air-bath shaker (200 rpm). Aliquots were withdrawn at specified time intervals from the reaction mixture and then diluted 50-fold with corresponding mobile phase priorto HPLC analysis. Regioselectivity was defined as the molar ratio of the desired product to the total amount of ester products formed. All data are averages of experiments performed in triplicate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | With lipozyme TL IM from Thermomyces lanuginosus; In tert-Amyl alcohol; dimethyl sulfoxide; at 52.0℃; for 0.583333h;Flow reactor; Enzymatic reaction; | General procedure: Method C: 0.49 mmol of the <strong>[13241-33-3]neohesperidin</strong> was dissolved in10 mL 2-methyl -2-butanol/DMSO 4:1 (feed 1, ~0.049 M) and3.92 mmol vinyl laurate or vinyl palmitate were dissolved in 10 mL2-methyl-2-butanol (feed 2; ~0.39 M). Lipozyme TL IM (0.87 g)were filled in silica gel tubing (inner diameter ID 2.0 mm,length 1 m). The next reaction procedure is similar to Method B. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With lipozyme TL IM from Thermomyces lanuginosus; In tert-Amyl alcohol; dimethyl sulfoxide; at 52℃; for 0.583333h;Flow reactor; Enzymatic reaction; | General procedure: Method C: 0.49 mmol of the <strong>[20702-77-6]neohesperidin</strong> was dissolved in10 mL 2-methyl -2-butanol/DMSO 4:1 (feed 1, ~0.049 M) and3.92 mmol vinyl laurate or vinyl palmitate were dissolved in 10 mL2-methyl-2-butanol (feed 2; ~0.39 M). Lipozyme TL IM (0.87 g)were filled in silica gel tubing (inner diameter ID 2.0 mm,length 1 m). The next reaction procedure is similar to Method B. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With immobilised Candida antarctica lipase B In dichloromethane at 20℃; for 1.5h; Enzymatic reaction; regioselective reaction; | 4.3. General Procedure A: enzymatic acylation procedure General procedure: To a mixture of benzyl protected glycerol (1.0 equiv.) and vinyl ester of the appropriate saturated fatty acid (1.05e1.3 equiv.) in CH2Cl2 (3.5 mL/mmol of substrate) was added immobilised Candida antarctica lipase B (CAL) (4e10 wt% of total combined mass of substrates). The resulting suspension was stirred at room temperature at a rate not to imperil the solid supported lipase. After stirring for 1.5 h (or until full consumption of starting material as indicated by TLC) the lipase was separated by filtration and the filtrate concentrated in vacuo to give the crude product which was purified by either flash column chromatography or recrystallisation (where appropriate). Note: 1-Acyl-3-O-alkylglycerols should be purified via column chromatography using 4% boric acid impregnated silica gel as they are prone to acyl migration. 4.4. 3-O-Benzyl-1-hexadecanoyl-sn-glycerol, (S)-13 (S)-13 was prepared using General Procedure A, with 3-Obenzyl-sn-glycerol (100 mg, 0.55 mmol, 1.0 equiv.), vinyl palmitate (117 mg, 0.63 mmol, 1.15 equiv.) and CAL (18 mg) in CH2Cl2 (2.0 mL), with a 1.5 h reaction time. Purification via column chromatography (4% boric acid impregnated silica gel, petroleum ether/EtOAc (40%)) gave (S)-13 (90 mg, 0.48 mmol, 87%) as a colourless oil; [a]D 25 1.11 (c 9.0, CH2Cl2); IR (NaCl, nmax/cm1 ) 3459, 3064, 3031, 2924, 2853, 1739, 1174; 1 H NMR (400 MHz, CDCl3) dH 7.39e7.27 (5H, m, ArH), 4.56 (2H, s, OCH2Ar), 4.19 (1H, dd, J 11.5 and 4.5 Hz, CH2OCO), 4.14 (1H, dd, J 11.5 and 6.0 Hz, CH2’OCO), 4.07e4.00 (1H, m, CHOCO), 3.56 (1H, dd, J 9.5 and 4.5 Hz, CH2OBn), 3.50 (1H, dd, J 9.5 and 6.0 Hz, CH2’OBn), 2.51 (1H, bs, OH), 2.32 (2H, t, J 7.5 Hz, CH2COO), 1.67e1.56 (2H, m, CH2CH2COO), 1.38e1.24 (24H, m, 12 CH2), 0.88 (3H, t, J 6.5 Hz, CH3); 13C NMR (100 MHz, CDCl3) dC 174.1, 137.8, 128.6, 128.0, 127.9, 73.7, 71.0, 69.1, 65.5 34.3, 32.1, 29.83, 29.80, 29.75, 29.6, 29.5, 29.4, 29.3, 25.1, 22.8, 14.3; HRMS (ESI) calc. for C26H44O4Na [MNa] 443.3132, found 443.3127. |
Tags: 693-38-9 synthesis path| 693-38-9 SDS| 693-38-9 COA| 693-38-9 purity| 693-38-9 application| 693-38-9 NMR| 693-38-9 COA| 693-38-9 structure
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P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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