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Chemical Structure| 695183-75-6 Chemical Structure| 695183-75-6

Structure of 695183-75-6

Chemical Structure| 695183-75-6

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Product Details of [ 695183-75-6 ]

CAS No. :695183-75-6
Formula : C7H13NO3
M.W : 159.18
SMILES Code : O=C([C@H]1NC[C@@H](O)CC1)OC
MDL No. :MFCD18828200

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Application In Synthesis of [ 695183-75-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 695183-75-6 ]

[ 695183-75-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 695183-75-6 ]
  • [ 915976-32-8 ]
YieldReaction ConditionsOperation in experiment
96% With potassium carbonate; In tetrahydrofuran; water; at 20.0℃; for 24.0h;Inert atmosphere; Cooling with ice; Methyl (2S, 5S) -5-hydroxypiperidin-2-carboxyate (21.10 g, 131.93 mmol) was dissolved in THF (240 mL) in a flask. Then K 2CO 3 (46.60 g, 337 mmol) was dissolved in H 2O (120 mL) , and the solution was added into the flask under ice-bath condition. The reaction mixture was mixed uniformly, then Boc 2O (45 mL, 200 mmol) was added dropwise slowly under ice-bath condition. The mixture was stirred at room temperature for 24 h. The mixture was extracted with EtOAc (200 mL×3) , and the combined organic layers were dried over anhydous Na 2SO 4, concentrated in vacuo to give yellow oil (33 g, 96%) . [2350] MS (ESI, pos. ion) m/z: 282.3 [M+23] +.
 

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