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CAS No. : | 70737-12-1 | MDL No. : | MFCD16621446 |
Formula : | C3H7Cl2NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZPKRTCMWHONHLA-UHFFFAOYSA-N |
M.W : | 144.00 | Pubchem ID : | 12680765 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P264-P271-P280-P302+P352-P304+P340+P312 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In diethyl ether; at 0℃; | A suspension of methyl chloroacetimidate hydrochloride (170 g, 1.58 mole, prepared by treating a solution of chloroacetonitrile in 1 :1 Et2OiMeOH with HCI gas at 0 0C, stirring at this temperature overnight and concentrating the reaction mixture to dryness) in DCM (2 L) was treated with 2-amino-5-nit.ro phenol (200 g, 1.3 mol). The EPO <DP n="50"/>suspension was stirred at room temperature for 24 hours then refluxed for 48 hours. The reaction mixture was washed with water (2 x 1L) and brine (1 x 1L), dried (Na2SO4), filtered and concentrated to give the crude product. The pure chloromethyl-benzoxazole (90 g, yellow solid) was obtained by chromatography on silica with 0 to 10 % MeOH in chloroform as eluent. | |
With hydrogenchloride; at 20℃;Cooling with ice; | 7.55g (100mmol) Compound IIIt was dissolved in 100mL anhydrous methanol,An ice-water bath to cool slowly leads to a dry HCl gas,To substantially saturated solution,Then stirred overnight at room temperature.The solid was collected by suction filtration,Vacuum-dried at room temperature,To give a white solid,It is the compound III. | |
With hydrogenchloride; at 20℃;Cooling with ice; | 7.55 g (lOO mmol) of compound II was dissolved in lOOmL anhydrous methanol, and the mixture was slowly passed through the ice-water bathHCl gas, until the solution is substantially saturated, and then stirred overnight at room temperature. The solid was collected by suction filtration and dried under vacuum at room temperature to give a white colorColor solid, that is, compound III. |
With hydrogenchloride; at 20℃;Cooling with ice; | 7.55 g (100 mmol) of compound II was dissolved in 100 mL anhydrous methanol. Cooled in the ice bath, dry HCl gas was slowly added until the solution was substantially saturated, followed by stirring overnight at room temperature. The solids were collected by suction filtration, and dried at room temperature in vacuum to give white solid, as the compound III. | |
With hydrogenchloride; at 20℃;Cooling with ice; | 7.55 g (100 mmol) of compound II was dissolved in 100 mL of anhydrous methanol and slowly passed through a dry lake of HCl under ice-cooling to cool the solution until the solution was saturated and stirred overnight at room temperature.The solid was collected by suction filtration and dried in vacuo at room temperature to give the title compound as a white solid. | |
With hydrogenchloride; In tert-butyl methyl ether; water; at 2℃; for 15h; | Into a mechanically stirred reactor, 3.02 kg (40 mol) of chloroacetonitrile was introduced.Methanol (moisture content 0.05%)1.28kg (40mol) and 33kg of methyl tert-butyl ether,Cool down to 2 C,Controlling a slow and uniform flow of 1.6 kg (44 mol) of dry HCl gas below this temperature,After the ventilation is completed,After stirring for 15 h, a large amount of white needle crystals were formed;The filter residue was filtered to obtain iminochloroethyl methyl ether hydrochloride.18kg of methanol was placed in the reaction kettle.Stirring to 50 C, then adding 6.1 kg of the iminochloroethyl methyl ether hydrochloride,And maintaining the reaction at 45 C for 2.5 hours;The reaction solution was stirred and cooled to 0 C.Filtered; the filtrate was stirred and warmed to 20 C.Adding 0.9 kg (8.07 mol) of semicarbazide hydrochloride,And maintaining the reaction at this temperature for 70 hours;The reaction solution was filtered, and the filtrate was concentrated to dryness under reduced pressure at 50 C to 50 C.The obtained solid was added with 6.5 kg of isopropanol.Heat and reflux for 30 min,The filtrate was filtered while hot, and the filtrate was cooled and crystallized at 5 C.Made of white fine needle crystals,Is 3-chloromethyl-1,2,4-triazolin-5-one, filtered,Drying at 50 C under vacuum to obtain a white powdery solid3-chloromethyl-1,2,4-triazolin-5-one 0.64kg,The total molar yield (based on semicarbazide hydrochloride) is 60%,The HPLC purity was 99.3%, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | In dichloromethane; | (A) 2-chloromethylbenzothiazole To a solution of aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride [prepared according to procedures described by R. Rogers and D. G. Nielson, Chem. Rev., 61, 179 (1961)] (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. |
71% | In dichloromethane; | A. 2-chloromethylbenzthiazole To a solution of aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride [prepared according to procedures described by R. Roger and D. G. Neilson, Chem. Rev., 61, 179 (1961)] (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water (3X); dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. |
71% | In dichloromethane; | (A) 2-chloromethylbenzothiazole To a solution of aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride [prepared according to procedures described by R. Rogers and D. G. Nielson, Chem. Rev., 61, 179 (1961)](8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. |
71% | In dichloromethane; | A. 2-Chloromethylbenzthiazole To a solution of 2-aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water (3X); dried over MgSO4 and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. 1 Prepared according to the procedure described in Roger et al., Chem. Rev., 61, 179 (1961). |
71% | In dichloromethane; | (B) 2-chloromethylbenzothiazole To a solution of aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. 1 Prepared according to procedures described by R. Rogers and D. G. Nielson, Chem. Rev., 61, 179 (1961). |
71% | In dichloromethane; | A. 2-chloromethylbenzthiazole To a solution of aminothiophenol (8.3 g) in methylene chloride at 0 C. is added methyl chloroacetimidate hydrochloride [prepared according to procedures described by R. Rogers and D. G. Nielson, Chem. Rev., 61, 179 (1961)] (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water (3X); dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120-135 C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; | (1) 2-(4-Methoxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride 2 ml of a methanolic solution containing 1.064 g of 4-methoxyiminopiperidine was added to a solution of 1.195 g of <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> in 4 ml of absolute methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off and the concentrate was mixed with anhydrous ether. The crystals which separated out were collected by filtration and washed with ether, giving 1.5 g of 2-(4-methoxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride. | |
In methanol; | (1) 2-(4-Methoxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride 2 ml of a methanolic solution containing 1.064 g of 4-methoxyiminopiperidine was added to a solution of 1.195 g of <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> in 4 ml of absolute methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off and the concentrate was mixed with anhydrous ether. The crystals which separated out were collected by filtration and washed with ether, giving 1.5 g of 2-(4-methoxyiminopiperidin-1-yl)-2-iminoethylchloride hydrochloride. NMR Spectrum (60 MHz, D2 O) δ ppm: 2.50-3.02 (4H, multiplet); 3.25-4.07 (4H, multiplet); 3.86 (3H, singlet); 4.57 (2H, singlet). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; | (1) 2-(3-Oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride 8.64 g of 2-oxopiperazine were added to a solution of 12.4 g of <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> in 44.8 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, a small amount of insoluble material was filtered off and the solvent was distilled off from the filtrate. Ether was added to the residue, and the precipitated crystals were collected by filtration and washed with ether, giving 18.0 g of 2-(3-oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride. | |
In methanol; | (1) 2-(3-Oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride 8.64 g of 2-oxopiperazine were added to a solution of 12.4 g of <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> in 44.8 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, a small amount of insoluble material was filtered off and the solvent was distilled off from the filtrate. Ether was added to the residue, and the precipitated crystals were collected by filtration and washed with ether, giving 18.0 g of 2-(3-oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride. NMR Spectrum (60 MHz, D2 O) δ ppm: 3.40-3.69 (2H, multiplet); 3.69-4.13 (2H, multiplet); 4.27 (2H, singlet); 4.59 (2H, singlet). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; | (1) 2-[(3RS)-3-Carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride 1.28 g of (3RS)-3-carbamoylpiperidine were added to a solution of 1.44 g of methyl 2-chloroacetimidate hydrochloride in 5 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; at 0 - 45℃; for 18.5h;Heating / reflux; | a.; A suspension of <strong>[70737-12-1]methyl chloroacetimidate hydrochloride</strong> (170 g, 1.58 mole, prepared by treating a solution of chloroacetonitrile in 1 :1 Et2O:MeOH with HCI gas at 0 0C, stirring at this temperature overnight and concentrating the reaction mixture to dryness) in DCM (100 mL) was cooled to 0 0C and treated with 2-amino-4-nitro phenol (6.4 g, 0.067 mol). The yellow suspension was stirred for 30 minutes at 0 0C and then at room temperature for 2 hours. The reaction was then heated to 45 0C for 16 hours. The reaction mixture was concentrated to dryness, and the product was crystallized from MeOH to yield a pale yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; at 20℃; for 72h;Heating / reflux; | A suspension of <strong>[70737-12-1]methyl chloroacetimidate hydrochloride</strong> (170 g, 1.58 mole, prepared by treating a solution of chloroacetonitrile in 1 :1 Et2OiMeOH with HCI gas at 0 0C, stirring at this temperature overnight and concentrating the reaction mixture to dryness) in DCM (2 L) was treated with 2-amino-5-nit.ro phenol (200 g, 1.3 mol). The EPO <DP n="50"/>suspension was stirred at room temperature for 24 hours then refluxed for 48 hours. The reaction mixture was washed with water (2 x 1L) and brine (1 x 1L), dried (Na2SO4), filtered and concentrated to give the crude product. The pure chloromethyl-benzoxazole (90 g, yellow solid) was obtained by chromatography on silica with 0 to 10 % MeOH in chloroform as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10.7 g | In methanol; for 1.5h;Reflux; | A mixture of methyl 3-(4-hydroxy-3-nitrophenyl)propanoate (2) (10.0 g, 44.4 mmol) and Pd/C (10%, 2.3 g, 2.22 mmol) was stirred tempestuously in 150 mL methanol under hydrogen (1.0 atm) for 1.0 h. The solution was filtered. The filtrate was concentrated to give a white solid, which was mixed with <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> (7.70 g, 53.29 mmol) in 150 mL methanol. The resulting mixture was heated at reflux for 1.5 h, and then it was cooled to room temperature and removed solvent in vacuum. The residue was diluted with 150 mL ethyl acetate. The organic layer was washed with 50 mL saturated NaHCO3 aqueous, then brine and dried over anhydrous Na2SO4. The solvent was removed to give a crude product, which was over silica gel column eluting with petroleum ether/ethyl acetate (10:1) to give compound 3 (10.7 g, 95%) as a colorless oil; 1H NMR (300 MHz, CDCl3) δ 7.54 (s, 1H, ArH), 7.45 (d, 1H, ArH, J = 9.0 Hz), 7.22 (dd, 1H, ArH, J = 8.4 Hz, 1.3 Hz), 4.73 (s, 2H, CH2), 3.65 (s, 3H, CH3), 3.05 (t, 2H, CH2, J = 7.7 Hz), 2.66 (t, 2H, CH2, J = 7.7 Hz); HRMS-ESI+: C12H12ClNO3 calcd [M + H]+ 254.0584, found 254.0573. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In N,N-dimethyl-formamide; at 80℃; for 3h; | 12.96g (90mmol) of compound III and 5.13g (90mmol) IV-1 was dissolved in 100mL dry DMF,Stirring at room temperature,Was added 12.14g (120mmol) triethylamine,Then the reaction temperature was raised to 80 deg.] C,Until completion of the reaction checked by TLC (typically 3 hours).After completion of the reaction,The reaction mixture was poured into 300mL ice water coolish,Stirring,Using the extracted with CH2Cl2 100mL × 3,The combined extract phase,Dried over anhydrous sodium sulfate.The desiccant was removed by suction,The filtrate was evaporated on a rotary evaporator,The residue was purified by column chromatography,To give the compound V-1,White solid | |
With triethylamine; In N,N-dimethyl-formamide; at 80℃; | 12 . 96g (90mmol) compound III and 5.13g (90mmol) IV-1 dissolved in 100 ml of dry DMF, stir at room temperature, adding 12.14g (120mmol) triethylamine, and then the temperature is increased to 80 C reaction, reaction is finished until the TLC check (usually 3 hours). After the completion of reaction, the reaction mixture after slightly cold 300 ml ice water, stirring, using 100 ml × 3 the CH 2 Cl 2 extraction, combined extract phase, drying anhydrous sodium sulfate. Suction filtering to drying agent, the filtrate on the rotary evaporimeter to dryness, the residue is purified using column chromatography, to obtain compound V-1, white solid, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
6.4 g | A mixture of compound 12 (1.1g, 3.0mmol) and Pd/C (10%, 0.2g) was stirred in 10mL MeOH under hydrogen (1atm) for 1h. The solution was filtered to give a white solid and it was mixed with <strong>[70737-12-1]methyl 2-chloroacetimidate hydrochloride</strong> (0.5g, 3.7mmol) in 25mL MeOH. The resulting mixture was heated at reflux for 2h, then it was cooled to room temperature and solvent was removed in vacuo. The residue was diluted with 50mL ethyl acetate and washed with 20mL saturated NaHCO3 aqueous solution, then brine and dried over anhydrous Na2SO4. The solvent was removed to give a crude product, which was over silica gel column eluting with petroleum ether/ethyl acetate (3:1) to give compound 13 (6.4g, 51%) as a colorless oil; 1H NMR (300MHz, CDCl3) δ 7.68 (s, 1H, ArH), 7.47 (d, 1H, ArH, J=8.4Hz), 7.33 (dd, 1H, ArH, J=8.1Hz, 1.5Hz), 7.23 (d, 2H, ArH, J=9.3Hz), 6.74 (d, 2H, ArH, J=8.7Hz), 4.81-4.77 (m, 1H, CH), 4.73 (s, 2H, CH2), 3.74 (s, 3H, CH3), 3.35 (d, 2H, CH2, J=5.4Hz), 1.25 (s, 9H, 3CH3); HRMS-ESI+: C22H25ClNO4 calcd [M+H]+: 402.1472, found 402.1471. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; at 20℃;Cooling with ice; | 7 . 55g (100mmol) compound II dissolved in 100 ml anhydrous methanol, under cooling ice slowly into the dry HCl gas, to the solution is substantially saturated, and then at room temperature overnight under stirring. Filtering collecting solid, vacuum drying at room temperature, to obtain white solid, compound III is. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In N,N-dimethyl-formamide; at 80℃; | 12.96 g (90mmol) of compound III and 8.91 g (90 mmol) of compound IV-1 were dissolved in 100mL of dry DMF, and the mixture was stirred at room temperature. 12.14g (120mmol) of triethylamine was added, the reaction temperature was then raised to 80 C, and TLC was checked till the completion of the reaction (typically 3 hours). After completion of the reaction, the reaction mixture was slightly cooled and poured into 300mL ice water, stirred, and extracted using 100 mL × 3 CH2Cl2. The extracted phases were combined, and dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration, and the filtrate was evaporated to dryness on a rotary evaporator. The residue was purified by column chromatography to give the compound V-1, a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; | 12.96 g (90 mmol) of compound III and 8.378 (90 ml) of IV-1 were dissolved in 100 ml of dry,After stirring, 12.14 g (120 mmol) of triethylamine was added and the temperature was raised to 80 C until the TLC check reaction was complete (usually 3 hours).After completion of the reaction,The reaction mixture was slightly cooled and poured into 300 mL of ice water, stirred, using 100 mL of X3 CH2C12Take the combined extraction phase and dry over anhydrous sodium sulfate. The desiccant was removed by suction filtration, and the filtrate was evaporated to dryness on a rotary evaporator to give the residueThe residue was purified by column chromatography to give the compound as a white solid | |
With triethylamine; In N,N-dimethyl-formamide; at 20 - 80℃; for 3h; | 12.96 g (90 mmol) of Compound III and 8.37 g (90 mmol) of IV-1 were dissolved in 100 mL of dry DMF and stirred at room temperature. 12.14 g (120 mmol) of triethylamine was added and the temperature was raised to 80 C until the TLC (Usually 3 hours).After completion of the reaction, the reaction mixture was slightly cooled and poured into 300 mL of ice water, stirred, and 100 mL of 3 CH2Cl2Extraction, combined extraction phase, anhydrous sodium sulfate drying.The filtrate was evaporated to dryness on a rotary evaporator and the resulting residue was purified by column chromatography to give compound V-1, white solid, ESI-MS, m / z = 169 ([M + H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; at 20℃; for 36h;Cooling with ice; | Ice bathChloroimine acetate methyl ester hydrochloride 4(3.6g, 25mmol)Dichloromethane (60mL)Adding amino alcohol (20mmol)And triethylamine (3.4 mL, 25 mmol).Return the system to room temperature and continue the reaction for about 36 hours.Stop stirring when the reaction system changes from white turbid to light pink.After filtering through celite, the solvent was removed under reduced pressure.The crude product was purified by column chromatography (PE/EtOAc = 2/1)A pure monooxazoline compound is obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | In methanol; for 70h; | Into a mechanically stirred reactor, 3.02 kg (40 mol) of chloroacetonitrile was introduced.Methanol (moisture content 0.05percent)1.28kg (40mol) and 33kg of methyl tert-butyl ether,Cool down to 2 ° C,Controlling a slow and uniform flow of 1.6 kg (44 mol) of dry HCl gas below this temperature,After the ventilation is completed,After stirring for 15 h, a large amount of white needle crystals were formed;The filter residue was filtered to obtain iminochloroethyl methyl ether hydrochloride.18kg of methanol was placed in the reaction kettle.Stirring to 50 ° C, then adding 6.1 kg of the iminochloroethyl methyl ether hydrochloride,And maintaining the reaction at 45 ° C for 2.5 hours;The reaction solution was stirred and cooled to 0 ° C.Filtered; the filtrate was stirred and warmed to 20 ° C.Adding 0.9 kg (8.07 mol) of semicarbazide hydrochloride,And maintaining the reaction at this temperature for 70 hours;The reaction solution was filtered, and the filtrate was concentrated to dryness under reduced pressure at 50 ° C to 50 ° C.The obtained solid was added with 6.5 kg of isopropanol.Heat and reflux for 30 min,The filtrate was filtered while hot, and the filtrate was cooled and crystallized at 5 ° C.Made of white fine needle crystals,Is 3-chloromethyl-1,2,4-triazolin-5-one, filtered,Drying at 50 ° C under vacuum to obtain a white powdery solid3-chloromethyl-1,2,4-triazolin-5-one 0.64kg,The total molar yield (based on semicarbazide hydrochloride) is 60percent,The HPLC purity was 99.3percent, |
Tags: 70737-12-1 synthesis path| 70737-12-1 SDS| 70737-12-1 COA| 70737-12-1 purity| 70737-12-1 application| 70737-12-1 NMR| 70737-12-1 COA| 70737-12-1 structure
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P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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