Alternatived Products of [ 712-29-8 ]
Product Details of [ 712-29-8 ]
| CAS No. : | 712-29-8 |
MDL No. : | MFCD00039724 |
| Formula : |
C7H7N5O2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | XGWIBNWDLMIPNF-UHFFFAOYSA-N |
| M.W : | 193.16 |
Pubchem ID : | 135415975 |
| Synonyms : |
|
Application In Synthesis of [ 712-29-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 712-29-8 ]
- Downstream synthetic route of [ 712-29-8 ]
- 1
-
[ 712-29-8 ]
-
[ 108-24-7 ]
-
[ 694514-39-1 ]
Reference：
[1]Waller et al.
[Journal of the American Chemical Society, 1950, vol. 72, p. 4630,4632]
Karrer; Schwyzer
[Helvetica Chimica Acta, 1949, vol. 32, p. 423,432,][Helvetica Chimica Acta, 1950, vol. 33, p. 39,43]
Backer; Houtman
[Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 725,728]
- 2
-
[ 712-29-8 ]
-
[ 108-24-7 ]
-
[ 32363-58-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 78% |
In acetic acid for 3h; Heating; |
|
| 70% |
for 3h; Heating; |
|
Reference：
[1]Yao, Qizheng; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2003, vol. 86, # 1, p. 1 - 12]
[2]Boyle, Peter H.; Pfleiderer, Wolfgang
[Chemische Berichte, 1980, vol. 113, # 4, p. 1514 - 1523]
[3]Waller et al.
[Journal of the American Chemical Society, 1950, vol. 72, p. 4630,4632]
Karrer; Schwyzer
[Helvetica Chimica Acta, 1949, vol. 32, p. 423,432,][Helvetica Chimica Acta, 1950, vol. 33, p. 39,43]
Backer; Houtman
[Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 725,728]
- 3
-
[ 712-30-1 ]
-
[ 712-29-8 ]
-
[ 948-60-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sodium hydroxide |
|
|
With sodium hydroxide |
|
- 4
-
[ 712-29-8 ]
-
[ 3672-03-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With potassium hydroxide; zinc 1.) water, room temp., in dark, 5 min; 2.) 55 deg C, 1 min; |
|
- 5
-
[ 712-29-8 ]
-
[ 31969-10-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With hydrogen In trifluoroacetic acid for 1h; |
|
|
With hydrogen In trifluoroacetic acid at 20℃; for 4h; |
|
|
With hydrogen; benzenesulfonic acid In methanol at 70℃; for 15h; |
C27
Example C27; 8.12 mg of [Rh(COD)2]BF4 (20 μmoles) and 15.57 mg of BINAP (25 μmoles) are weighed, degassed and dissolved in a mixture of tetrahydrofuran and methanol. The solvents are condensed off under a high vacuum and the residue is taken up in 5 ml of methanol. A suspension of 0.39 g of 6-hydroxymethyl pterin (2 mmoles) (prepared as per P. H. Boyle et al., Chem. Ber.; vol. 113, page 1514, 1980) and 0.32 g of benzene sulphonic acid (2 mmoles) in 25 ml of methanol is added to the catalyst. The mixture is added in a nitrogen countercurrent to a 100 ml autoclave and hydrogenated at 70° C. and 80 bars hydrogen pressure for 15 hours. The conversion rate to 6-hydroxymethyl-5,6,7,8-tetrahydropterin is 85% and is determined by HPLC direct from the reaction solution. The HPLC method employed is the same one as is used for the quantitative determination of the tetrahydrofolic acid. |
Reference：
[1]Lunte, Craig E.; Kissinger, Peter T.
[Analytical Chemistry, 1983, vol. 55, p. 1458 - 1462]
[2]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
[3]Current Patent Assignee: MERCK KGAA - US2008/306263, 2008, A1
Location in patent: Page/Page column 18
- 6
-
[ 73978-41-3 ]
-
[ 712-29-8 ]
- 7
-
[ 712-29-8 ]
-
[ 4637-24-5 ]
-
2-(N,N-dimethylaminomethyleneamino)-6-hydroxymethylpteridin-4(3H)-one
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 94% |
In N,N-dimethyl-formamide at 50℃; for 2h; |
|
| Yield | Reaction Conditions | Operation in experiment |
|
Beim Aufbewahren in Trifluoressigsaeure wird die Substanz verestert (s. NMR); |
|
|
Ox. (alkal. wss. KMnO4, 100grad) -> Pterin-6-carbonsaeure; |
|
|
With oxygen; rose bengal In water-d2 Irradiation; |
|
|
In aq. buffer Enzymatic reaction; |
|
| Yield | Reaction Conditions | Operation in experiment |
|
With pteridine reductase: dihydrofolate reductase from Crithidia fasciculata at 30℃; pH 6.0; Michaelis constant determination, other pH; |
|
| Yield | Reaction Conditions | Operation in experiment |
|
6-Formyl-7,8-dihydro-pterin-hydrazon, Aufbewahren in Trifluoressigsaeure; |
|
|
6-Formylpterin VIII, NaBH4; |
|
- 11
-
[ 5221-17-0 ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With ethanol; iodine; sodium acetate bei pH 4; |
|
- 12
-
[ 96-26-4 ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sodium acetate; hydrazine hydrate; acetic acid |
|
|
With sodium acetate; hydrazine hydrate; acetic acid Reagens 4:H3BO3; |
|
Reference：
[1]Karrer; Schwyzer
[Helvetica Chimica Acta, 1949, vol. 32, p. 423,432,][Helvetica Chimica Acta, 1950, vol. 33, p. 39,43]
Current Patent Assignee: ROCHE HOLDING AG - CH250660, 1946, A
Current Patent Assignee: Hoffmann-La Roche - US2546959, 1947, A
Backer; Houtman
[Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 725,728]
Forrest; Walker
[Journal of the Chemical Society, 1949, p. 2077,2079 Anm.,2081]
[2]Karrer; Schwyzer
[Helvetica Chimica Acta, 1949, vol. 32, p. 423,432,][Helvetica Chimica Acta, 1950, vol. 33, p. 39,43]
Current Patent Assignee: ROCHE HOLDING AG - CH250660, 1946, A
Current Patent Assignee: Hoffmann-La Roche - US2546959, 1947, A
Backer; Houtman
[Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 725,728]
Forrest; Walker
[Journal of the Chemical Society, 1949, p. 2077,2079 Anm.,2081]
- 13
-
[ 26944-17-2 ]
-
2,5,6-triamino-3<i>H</i>-pyrimidin-4-one sulfate
[ No CAS ]
-
[ 694514-39-1 ]
-
[ 712-29-8 ]
- 14
-
[ 712-29-8 ]
-
[ 49754-41-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With phosphoric acid at 60 - 65℃; for 4h; |
|
- 15
-
[ 712-30-1 ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sodium tetrahydroborate |
|
- 16
-
[ 712-29-8 ]
-
[ 97-72-3 ]
-
N-{6-[(isobutyryloxy)methyl]-3,4-dihydro-4-oxopteridin-2-yl}isobutyramide
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 78% |
With pyridine for 4h; Heating; |
|
| 62% |
With pyridine for 5h; Reflux; |
|
Reference：
[1]Yao, Qizheng; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2003, vol. 86, # 1, p. 1 - 12]
[2]Location in patent: experimental part
Rehse, Joachim; Pfleiderer, Wolfgang
[Heterocycles, 2009, vol. 77, # 2, p. 953 - 970]
- 17
-
[ 712-29-8 ]
-
[ 4637-24-5 ]
-
[ 222612-05-7 ]
| Yield | Reaction Conditions | Operation in experiment |
| 85% |
In N,N-dimethyl-formamide at 20℃; for 2h; |
|
- 18
-
[ 712-29-8 ]
-
[ 945-24-4 ]
- 19
-
[ 712-29-8 ]
-
[ 522614-26-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 85 percent / dimethylformamide / 2 h / 20 °C
2: 76 percent / pyridine / 18 h / 20 °C |
|
- 20
-
[ 712-29-8 ]
-
2-amino-6-(hydroxymethyl)-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: 85 percent / dimethylformamide / 2 h / 20 °C
2: 76 percent / pyridine / 18 h / 20 °C
3: 71 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C
4: 73 percent / conc. aq. NH3 / methanol / 48 h / 20 °C |
|
- 21
-
[ 712-29-8 ]
-
2-amino-4-[2-(4-nitrophenyl)ethoxy]pteridin-6-methanol 6-acetate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 78 percent / acetic acid / 3 h / Heating
2: 70 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C
3: 61 percent / MeOH / 72 h / 20 °C |
|
- 22
-
[ 712-29-8 ]
-
[ 522614-28-4 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 85 percent / dimethylformamide / 2 h / 20 °C
2: 76 percent / pyridine / 18 h / 20 °C
3: 71 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C |
|
- 23
-
[ 712-29-8 ]
-
[ 522614-11-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 78 percent / acetic acid / 3 h / Heating
2: 70 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C |
|
- 24
-
[ 712-29-8 ]
-
N-{6-[(isobutyryloxy)methyl]-4-[2-(4-nitrophenyl)ethoxy]pteridin-2-yl}isobutyramide
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 78 percent / pyridine / 4 h / Heating
2: 41 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C |
|
- 25
-
[ 59-30-3 ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 40 percent aq. HBr / 2 h / 100 °C
2: NaBH4 |
|
- 26
-
[ 712-29-8 ]
-
6-[(4-azidobenzoyl)oxy]methyl}-5,6,7,8-tetrahydropterin
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 56 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 18 h / 20 °C
5: 91 percent / aq. HCl / methanol
6: DBU / dimethylformamide / 20 °C |
|
|
Multi-step reaction with 6 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 63 percent / N,N-dimethylpyridin-4-amine / pyridine / 25 h / 20 °C
5: 91 percent / aq. HCl / methanol
6: DBU / dimethylformamide / 20 °C |
|
Reference：
[1]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
[2]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
- 27
-
[ 712-29-8 ]
-
[ 325708-61-0 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C |
|
- 28
-
[ 712-29-8 ]
-
(2-amino-3,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl)methyl 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 75 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C
5: 78 percent / conc. HCl / methanol / 24 h / 20 °C
6: DBU / dimethylformamide / 14 h / 20 °C |
|
- 29
-
[ 712-29-8 ]
-
[ 325708-69-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C |
|
- 30
-
[ 712-29-8 ]
-
6-[3-(4-benzoylphenyl)-1-oxopropoxy]methyl}-5,6,7,8-tetrahydropterin
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 80 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C
5: 80 percent / aq. HCl / methanol / 24 h / 20 °C
6: DBU / dimethylformamide / 14 h / 20 °C |
|
- 31
-
[ 712-29-8 ]
-
[ 325708-72-3 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 56 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 18 h / 20 °C |
|
|
Multi-step reaction with 4 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 63 percent / N,N-dimethylpyridin-4-amine / pyridine / 25 h / 20 °C |
|
Reference：
[1]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
[2]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
- 32
-
[ 712-29-8 ]
-
[ 325708-82-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 75 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C |
|
- 33
-
[ 712-29-8 ]
-
[ 325708-89-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 80 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C
5: 80 percent / aq. HCl / methanol / 24 h / 20 °C |
|
- 34
-
[ 712-29-8 ]
-
[ 325708-78-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 80 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C |
|
- 35
-
[ 712-29-8 ]
-
2-(4-nitrophenyl)ethyl 2-amino-6-[(4-azidobenzoyl)oxy]methyl}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate hydrochloride
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 56 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 18 h / 20 °C
5: 91 percent / aq. HCl / methanol |
|
|
Multi-step reaction with 5 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 63 percent / N,N-dimethylpyridin-4-amine / pyridine / 25 h / 20 °C
5: 91 percent / aq. HCl / methanol |
|
Reference：
[1]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
[2]Groehn, Viola; Froehlich, Lothar; Schmidt, Harald H. H. W.; Pfleiderer, Wolfgang
[Helvetica Chimica Acta, 2000, vol. 83, # 10, p. 2738 - 2750]
- 36
-
[ 712-29-8 ]
-
2-(4-nitrophenyl)ethyl 2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-[({4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoyl}oxy)methyl]pteridine-5-carboxylate hydrochloride
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: H2 / PtO2 / trifluoroacetic acid / 4 h / 20 °C
2: 86 percent / pyridine / 12 h / 20 °C
3: 57 percent / dimethylformamide / 2.5 h / 20 °C
4: 75 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 14 h / 20 °C
5: 78 percent / conc. HCl / methanol / 24 h / 20 °C |
|
- 37
-
[ 712-29-8 ]
-
[ 73978-45-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 70 percent / 3 h / Heating
2: 8 percent / H2O / 7.5 h / Heating |
|
- 38
-
Folic acid
[ No CAS ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: Na2SO3; aqueous acetic acid
2: aqueous NaOH |
|
- 39
-
[ 712-29-8 ]
-
[ 98-11-3 ]
-
6-hydroxymethyl-5,6,7,8-tetrahydropterin
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 85% |
Stage #1: In tetrahydrofuran; methanol
Stage #2: 6-(hydroxymethyl)pterin; benzenesulfonic acid With hydrogen In methanol at 70℃; for 15h; |
C27 Beispiel C27
8,12 mg [Rh(COD)2]BF4 (20 umol) und 15,57 mg BINAP (25 umol) werden eingewogen, entgast und in einer Mischung aus Tetrahydrofuran und Methanol gelost. Die Losungsmittel werden im Hochvakuum abkondensiert und der Ruckstand in 5 ml Methanol aufgenommen. Zum Katalysator wird eine Suspension aus 0,39 g 6-Hydroxymethylpterin (2 mmol) (hergestellt nach P.H. Boyle et al., Chem. Ber.; Bd. 113, Seite 1514, 1980) und 0,32 g Benzolsulfonsaure (2 mmol) in 25 ml Methanol gegeben. Die Mischung wird im Stickstoffgegenstrom in einen 100 ml Autoklaven gegeben und bei 70oC und 80 bar Wasserstoffdruck 15 Stunden lang hydriert. Der Umsatz zu 6-Hydroxymethyl-5,6,7,8-tetrahydropterin betragt 85% und wird mit HPLC direkt aus der Reaktionslosung bestimmt. Die verwendete HPLC-Methode ist die gleiche, die fur die quantitative Bestimmung der Tetrahydrofolsaure verwendet wird. |
- 40
-
[ 712-29-8 ]
-
cobalt(II) acetate
[ No CAS ]
-
Co{2-amino-6-(hydroxymethyl)-4-oxopteridine}2(H2O)5*DMSO
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 79% |
With DMSO In tetrahydrofuran; dimethyl sulfoxide addn. of cobalt acetate in 5 ml DMSO to a warm (50-60 °C) soln. of HMP in 30 ml DMSO.; addn. of THF and chilling the mixt. overnight in a freezer.; |
|
- 41
-
[ 96-26-4 ]
-
2,5,6-triaminopyrimidin-4(3H)-one dihydrochloride
[ No CAS ]
-
[ 694514-39-1 ]
-
[ 712-29-8 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Stage #1: dihydroxyacetone; 2,5,6-triaminopyrimidin-4(3H)-one dihydrochloride With l-cysteine hydrochloride; sodium acetate In water at 20℃; for 2h;
Stage #2: In water at 20℃; for 24h; |
|
- 42
-
[ 712-29-8 ]
-
[ 6863-06-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With wildtype 6-hydroxymethyl-3,4-dihydropterin pyrophosphokinase from Escherichia coli; ATP Enzymatic reaction; |
|
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