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Chemical Structure| 716362-14-0 Chemical Structure| 716362-14-0

Structure of 716362-14-0

Chemical Structure| 716362-14-0

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Product Details of [ 716362-14-0 ]

CAS No. :716362-14-0
Formula : C8H7ClFNO2
M.W : 203.60
SMILES Code : O=C(OC)C1=CC(N)=C(Cl)C=C1F
MDL No. :MFCD17276528
InChI Key :QAHQRQDFBRPYAO-UHFFFAOYSA-N
Pubchem ID :63022791

Safety of [ 716362-14-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332-H315-H319-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 716362-14-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 716362-14-0 ]

[ 716362-14-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 716362-14-0 ]
  • [ 951884-02-9 ]
YieldReaction ConditionsOperation in experiment
With copper(ll) bromide; isopentyl nitrite; In acetonitrile; at 65.0℃; for 2.0h; lsoamyl nitrite (12.7 ml_, 94.8 mmol) was added to 5-amino-4-chloro-2- fluoro-benzoic acid methyl ester (14.8 g, 72.9 mmol) in acetonitrile (280 mL), followed by addition of CuBr2 (21.1 g, 94.8 mmol). Then the mixture was heated at 65 0C with stirring for 2 hrs, followed by partition between ethyl acetate and water. The organic layer was then washed with saturated NaHCO3 and brine and was dried over Na2SO4. The filtrate was concentrated and purified by silica gel chromatography eluting with ethyl acetate/hexane (1/1 ) to yield 5-bromo-4-chloro-2-fluoro-benzoic acid methyl ester (14.O g). MS: 268.0 (M+) from GC-MS; tR=2.53 min (method 1 );
 

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