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Chemical Structure| 7169-06-4 Chemical Structure| 7169-06-4

Structure of 7169-06-4

Chemical Structure| 7169-06-4

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Product Details of [ 7169-06-4 ]

CAS No. :7169-06-4
Formula : C9H9ClO3
M.W : 200.62
SMILES Code : O=C(Cl)C1=CC=CC(OC)=C1OC
MDL No. :MFCD03424705
InChI Key :JQNBCSPQVSUBSR-UHFFFAOYSA-N
Pubchem ID :2758392

Safety of [ 7169-06-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 7169-06-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7169-06-4 ]

[ 7169-06-4 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 141-97-9 ]
  • [ 7169-06-4 ]
  • [ 38480-94-3 ]
  • 3
  • [ 506-82-1 ]
  • [ 7169-06-4 ]
  • [ 38480-94-3 ]
  • 6
  • [ 7169-06-4 ]
  • [ 67984-81-0 ]
  • 7
  • [ 34589-97-4 ]
  • [ 7169-06-4 ]
  • C18H19NO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Pyridine (4 mL) was added to 2- methoxybenzoylmethylammonium chloride (8a)/benzoylmethylammonium chloride (8b) salt (0.5 mmol) and stirred for 10 min at room temperature. To this mixture, above corresponding acid chloride was added slowly and stirred for 1 h under nitrogen atmosphere. After completion of the reaction, water (4 mL) was added, neutralized with 3 N HCl, and extracted with EtOAc (2 × 20 mL). The combined organic layer was washed with water (2 × 15 mL), brine (15 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. To this crude, acetic anhydride (3 mL) followed by conc. H2SO4 (0.1 mL) were added at room temperature and the mixture was stirred at 90C for 1 h. After completion of the reaction, cooled to room temperature, H2O (5 mL) was added. The mixture was neutralized with saturated aqueous NaHCO3 and extracted with EtOAc (2 × 25 mL). The combined organic layer was washed with water (2 × 15 mL), brine (15 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude was purified by column chromatography (EtOAc:hexane = 1:3) to afford the pure oxazole product.
  • 8
  • [ 34589-97-4 ]
  • [ 7169-06-4 ]
  • 2-(2,3-dimethoxyphenyl)-5-(2-methoxyphenyl)oxazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% General procedure: b) Pyridine (4 mL) was added to a solution of <strong>[34589-97-4]2-methoxybenzoylmethylammonium chloride</strong>(Compound 8a) / benzoylmethylammonium chloride (Compound 8b)Was added to the salt (0.5 mmol) and stirred at ambient temperature for 10 min.To the mixture was slowly added the corresponding acid chloride,And the mixture was stirred under a nitrogen atmosphere for 1 hour. After completion of the reaction,Water (4 mL) was added, neutralized with 3N HCl, extracted with EtOAc (2 x 20 mL). The combined organic solvent layers were washed with H2O (2 x 15 mL) and brine (15 mL), dried over anhydrous Na2SO4,And concentrated in vacuo.To this crude compound was added acetic anhydride (3 mL) followed by saturated H 2 SO 4 (0.1 mL) at room temperature, and the mixture was stirred at 90 C. for 1 hour. After completion of the reaction, the reaction mixture was cooled to room temperature,H2O (5 mL) was added. The mixture was neutralized with saturated NaHCO3 solution and extracted with EtOAc (2 x 25 mL).The combined organic solvent layers were washed with H2O (2 x 15 mL) and brine (15 mL), dried over anhydrous Na2SO4 and concentrated in vacuo.Column chromatography (EtOAc: Hexane = 1: 3)The crude compound was purified by silica gel column chromatography to obtain a pure oxazole compound.
59% b) Pyridine (4 mL) was added to a salt of <strong>[34589-97-4]2-methoxybenzoylmethylammonium chloride</strong> (compound 8a) / benzoylmethylammonium chloride (compound 8b) (0.5 mmol)The mixture was stirred at room temperature for 10 minutes.To this mixture,The corresponding acid chloride is slowly added,And the mixture was stirred under a nitrogen atmosphere for 1 hour.After completion of the reaction,Water (4 mL) was added,Neutralized with 3N HCl,And extracted with EtOAc (2 x 20 mL). The combined organic solvent layers were washed with H2O (2 x 15 mL) and brine (15 mL)And dried over anhydrous Na2SO4,And concentrated in vacuo.To this crude compound was added acetic anhydride (3 mL) followed by saturated H 2 SO 4 (0.1 mL) at room temperature, and the mixture was stirred at 90 C. for 1 hour.After completion of the reaction, the reaction mixture was cooled to room temperature,H2O (5 mL) was added.The mixture was neutralized with saturated NaHCO3 solution,And extracted with EtOAc (2 x 25 mL).The combined organic solvent layers were washed with H2O (2 x 15 mL) and brine (15 mL), dried over anhydrous Na2SO4 and concentrated in vacuo. The crude compound was purified by column chromatography (EtOAc: Hexane = 1: 3) to obtain a pure oxazole compound.
 

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