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Chemical Structure| 7179-93-3 Chemical Structure| 7179-93-3

Structure of 7179-93-3

Chemical Structure| 7179-93-3

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Product Details of [ 7179-93-3 ]

CAS No. :7179-93-3
Formula : C6H13NO
M.W : 115.17
SMILES Code : CNCC1COCC1
MDL No. :MFCD09040652
InChI Key :ZUGRRINNTXSWBR-UHFFFAOYSA-N
Pubchem ID :16228714

Safety of [ 7179-93-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H335-H314
Precautionary Statements:P210-P240-P241-P242-P243-P260-P264-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P233-P403+P235-P405-P501
Class:3(8)
UN#:2733
Packing Group:

Application In Synthesis of [ 7179-93-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7179-93-3 ]

[ 7179-93-3 ] Synthesis Path-Downstream   1~6

YieldReaction ConditionsOperation in experiment
EXAMPLE 6 Preparation of 1-[N-{(tetrahydro-3-furanyl)methyl}-N-methylamino]-1-methylamino-2-nitroethylene (Compound No. 6) A mixture comprising 1.42 g of (tetrahydro-3-furanyl)methyl tosylate, 0.15 g of sodium iodide, 1.70 g of potassium carbonate and 18 ml of 40% methylamine in methanol solution was heated under reflux for 5 hours. After separation of insoluble matters by filtration, the reaction fluid was concentrated under a reduced pressure to obtain crude N-{(tetrahydro-3-furanyl)methyl}-N-methylamine.
  • 2
  • [ 554411-25-5 ]
  • [ 7179-93-3 ]
  • [ 1885-14-9 ]
  • [ 798533-06-9 ]
YieldReaction ConditionsOperation in experiment
80% EXAMPLE 25 3-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-1-methyl-1-(tetrahydro-furan-3-ylmethyl)-urea Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and <strong>[7179-93-3]methyl-(tetrahydro-furan-3-ylmethyl)-amine</strong>, the title compound was prepared as white crystals (80% yield). MS: m/e=406(M+H+), mp 185-186 C.
  • 3
  • [ 7179-93-3 ]
  • [ 1206677-83-9 ]
  • N-cyano-N'-{(tetrahydro-3-furanyl)methyl}-N-methylacetamidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; EXAMPLE 16 Preparation of N-cyano-N'-{(tetrahydro-3-furanyl)methyl}-N-methylacetamidine (Compound No. 51) A mixture comprising 1.0 g of N-{(tetrahydro-3-furanyl)methyl}-N-methylamine, 0.4 g of ethyl N-cyanoacetamidate and 10 ml of ethanol was stirred for 7 hours at room temperature. The reaction fluid was concentrated under a reduced pressure and purified by silica gel column chormatography (eluent: ethyl acetate) to obtain 0.38 g of N-cyano-N'-{(tetrahydro-3-furanyl)methyl}-N-methylacetamidine.
  • 4
  • [ 7179-93-3 ]
  • [ 1447723-92-3 ]
  • [ 1447726-06-8 ]
YieldReaction ConditionsOperation in experiment
44 mg With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80℃; for 3h; 7.08.01. 2-(3, 5-bis-(4-fiuoro-phenyl)-(l, 2, 4) triazol-l-yl)-l-(4-(6-(methyl-(tetrahydro- furan-3 -ylmethyl)-amino)-pyrimidin-4-yl)-piperazin- 1 -yl)-ethanone 58 mg <strong>[7179-93-3]methyl-(tetrahydro-furan-3-ylmethyl)-amine</strong> was added to 50 mg 2-(3, 5-Bis-(4-fluoro- phenyl)-(l, 2, 4) triazol-l-yl)-l-(4-(6-chloro-pyrimidin-4-yl)-piperazin-l-yl)-ethanone and 35 μ DIPEA in 1 mL DMSO. The reaction was stirred 3h at 80C. The mixture was purified by HPLC to give 44 mg of the desired product. Rt: 2.13 min (method M), (M+H)+: 575
44 mg With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80℃; for 3h; 7.08.01. 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-(methyl-(tetrahydro-furan-3-ylmethyl)-amino)-pyrimidin-4-yl)-piperazin-1-yl)-ethanone 58 mg <strong>[7179-93-3]methyl-(tetrahydro-furan-3-ylmethyl)-amine</strong> was added to 50 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 35 μl DIPEA in 1 mL DMSO. The reaction was stirred 3 h at 80 C. The mixture was purified by HPLC to give 44 mg of the desired product. Rt: 2.13 min (method M), (M+H)+: 575
  • 5
  • [ 7179-93-3 ]
  • C11H9F6NOS [ No CAS ]
  • C15H19F3N2OS [ No CAS ]
  • 6
  • [ 7179-93-3 ]
  • ethyl 4-chloro-5-ethylthieno[2,3-d]pyrimidine-6-carboxylate [ No CAS ]
  • ethyl 5-ethyl-4-[methyl(tetrahydrofuran-3-ylmethyl)amino]thieno[2,3-d]pyrimidine-6-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a stirred solution of ethyl 4-chloro-5-ethyl-thieno[2,3-d]pyrimidine-6- carboxylate (120 mg, 0.44 mmol) in CH2CI2 (5 mL) was added NEt3 (0.19 mL, 1.33 mmol) at 0 C. After stirring at this temperature for 5 minutes, A-methyl-l- tetrahydrofuran-3-yl-methanamine (56 mg, 0.49 mmol) dissolved in 1 ml of CH2CI2 was added, and the reaction stirred for 16 h at 25 C. After the starting material wasconsumed, the reaction was quenched with crushed ice, diluted with CH2CI2 (200 mL), and the mixture washed with water (3x25 mL). The organic layer was dried overanhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product carried forward without additional purification. MS (ESI) [M+H]+ 349.7
 

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