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Chemical Structure| 71879-50-0 Chemical Structure| 71879-50-0

Structure of 71879-50-0

Chemical Structure| 71879-50-0

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Product Details of [ 71879-50-0 ]

CAS No. :71879-50-0
Formula : C9H17NO2
M.W : 171.24
SMILES Code : O=C(OC)CCC1CCNCC1
MDL No. :MFCD09055353

Safety of [ 71879-50-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 71879-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71879-50-0 ]

[ 71879-50-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58656-98-7 ]
  • [ 71879-50-0 ]
  • [ 1246248-06-5 ]
YieldReaction ConditionsOperation in experiment
31% With potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 16h;Inert atmosphere; Methyl 3-(piperidin-4-yl)propanoate (WO2004/9212 A2) (206 mg, 1.11 mmol) was dissolved in N,N-dimethylformamide (10 mL), <strong>[58656-98-7]ter<strong>[58656-98-7]t-butyl 4-fluorobenzoate</strong></strong> (141 mg, 1.11 mol) and potassium carbonate (100 mg, 1.11 mol) were added, and the mixture was stirred at 120C under a nitrogen atmosphere for 16 hours. After the reaction was completed, a saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture under ice cooling, and ethyl acetate was further added to separate the layers. The resulting organic layer was separated, washed with saturated sodium chloride solution, and then dried with anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by NH silica gel column chromatography (hexane:ethyl acetate, 10:1, v/v) to give the title compound (126 mg; yield, 31%) as a colorless oily substance. 1H HMR (CDCl3, 400 MHz) : 81.2-1.4 (2H, m), 1.5-1.6 (10H, m), 1.6-1.7 (2H, m), 1.7-1.8 (2H, m), 2.4-2.5 (2H, m), 2.7-2.8 (2H, m), 3.7 (3H, s), 3.8-3.9 (2H, m), 6.8-6.9 (2H, m), 7.7-7.8 (1H, m), 7.8-7.9 (2H, m).
  • 2
  • [ 58656-98-7 ]
  • [ 71879-50-0 ]
  • C16H21NO4 [ No CAS ]
 

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