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Chemical Structure| 719267-96-6 Chemical Structure| 719267-96-6

Structure of 719267-96-6

Chemical Structure| 719267-96-6

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Product Details of [ 719267-96-6 ]

CAS No. :719267-96-6
Formula : C5H8F2N2O
M.W : 150.13
SMILES Code : O=C(N)[C@H]1NCC(F)(F)C1
MDL No. :MFCD18828789

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Application In Synthesis of [ 719267-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 719267-96-6 ]

[ 719267-96-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 334769-80-1 ]
  • [ 719267-96-6 ]
  • [ 847943-30-0 ]
YieldReaction ConditionsOperation in experiment
56% With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In DMF (N,N-dimethyl-formamide);pH 6 - 7; Example 3F 2S (2S-CARBAMOYL-4, 4-DIFLUORO-PYRROLIDINE-1-CARBONYL)-5S-METHYL-PYRROLIDINE-1- carboxylic acid ter-butyl ester The compound from Example 3E (303 mg, 0.93 mmol), 5S-methyl- pyrrolidine-1, 2S-dicarboxylic acid 1-TERT-BUTYL ester (leq, prepared as described in Example 5) AND 2-(LH-BENZOKIAZOLE-1-YL)-L, 1, 3, 3-tetramethyluronium tetrafluoroborate (TBTU, 1.4 eq. ) were mixed in 2 mL of DMF, then Et3N was added until the pH of the mixture reached 6-7 (wet pH paper). The mixture was stirred overnight and purified by reverse-phase HPLC to provide the titled compound. (170 mg, 56percent).
 

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