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3-(6-bromo-3-nitroquinolin-4-yl)aminocyclopentanol[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
100%
With triethylamine; In dichloromethane; at 20℃; for 2.5h;
(XIX) Scheme XIX Intermediate 432: 3-(6-bromo-3-nitroquinolin-4-yl)aminocyclopentanol 1.69 g (5.9 mmol) of Compound 3 and 1.226 g (8.9 mmol) of <strong>[1184919-69-4]3-aminocyclopentanol hydrochloride</strong> (a mixture of cis and trans isomers) were dissolved in 20 ml of dichloromethane, added with 3.3 ml (23.6 mmol) of triethylamine, stirred at room temperature for 2.5 h to precipitate out solids, filtered, washed with a small amount of dichloromethane, and pumped to dryness to afford a yellow solid (2.154 g). Yield: 100%. LC-MS: 351.8, 353.8 [M+1]+, tR = 1.822 min.
4-((6-bromo-3-nitroquinolin-4-yl)amino)-1-methylcyclohexanol[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
Intermediate 460: 4-((6-bromo-3-nitroquinolin-4-yl)amino)-1-methylcyclohexanol 0.5 g (2.6 mmol) of Intermediate 459 and 0.86 g (8.5 mmol) of triethylamine were added into 20 ml of dichloromethane, stirred for 10 min, and then added with 0.5 g (1.7 mmol) of Intermediate 3, and stirred at room temperature overnight. The reaction solution was evaporated to dryness and purified by passing through a silica gel column, and collected two product fractions, to afford 170 mg of yellow solid (a mixture of cis and trans isomers). LC-MS: 380,382 [M+1]+, tR = 2.036&2.107 min.
Chemistry
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Material Science
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120K+ Compounds
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