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Chemical Structure| 72388-13-7 Chemical Structure| 72388-13-7

Structure of 72388-13-7

Chemical Structure| 72388-13-7

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Product Details of [ 72388-13-7 ]

CAS No. :72388-13-7
Formula : C7H16N2O3S
M.W : 208.28
SMILES Code : O=S(N1CCN(CCO)CC1)(C)=O
MDL No. :MFCD01212002

Safety of [ 72388-13-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 72388-13-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72388-13-7 ]

[ 72388-13-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19932-85-5 ]
  • [ 72388-13-7 ]
  • C14H18BrN3O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20℃;Inert atmosphere; General procedure: To a stirred solution of tert-butyl 6-nitro-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1carboxylate (CAS: 438200-95-4) (630 mg, 2.26 mmol), 2-(4-(methylsulfonyl)piperazin-1-ylethanol (CAS: 72388-13-7) (940 mg, 4.52 mmol) and PPh; (11186 mg, 4.52 mmol) in THF (30 mL) under Ar atmosphere at 0 C was added DEAD (984 mg, 5.65 mmol). The reaction mixture was stirred under Ar atmosphere at 50 C overnight. The reaction mixture was diluted with H2,O (50 mL) and extracted with EtOAc (3 X 50 mL). The combined organic extracts were washed with brine (SO mL), dried over anhydrous Na2SOuq,filtered and the filtrate was concentrated. The residue was purified bysilica gel chromatography (PE: EA = 1:1, v/v). The fractions were concentrated. The residue was dissolved in PE/EA(3/1, v/v, 20 mL), stirred at room temperature for 16 h, during which time white precipitate was formed. The mixture was filtered and the filter cake was collected to give intermediate 139 (1.36 g, 59% yield) as a white solid. Intermediates 212, 213, and 214 CHCI salt) were prepared respectively via an analogous reaction protocol as described for the preparation offollowing intermediates in the column ‘Method used’
 

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