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Structure of 724788-22-1

Chemical Structure| 724788-22-1

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Product Details of [ 724788-22-1 ]

CAS No. :724788-22-1
Formula : C10H20N2O3
M.W : 216.28
SMILES Code : O=C(OC(C)(C)C)N[C@@H]1[C@@H](O)CNCC1
MDL No. :MFCD22384728
InChI Key :MLTCALYMVICSBJ-YUMQZZPRSA-N
Pubchem ID :58395893

Safety of [ 724788-22-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 724788-22-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 724788-22-1 ]

[ 724788-22-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19745-07-4 ]
  • [ 724788-22-1 ]
  • tert-butyl ((3S,4S)-1-(5-chloropyrazin-2-yl)-3-hydroxypiperidin-4-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
40% With potassium carbonate; In dimethyl sulfoxide; at 90℃; for 12h; A solution of <strong>[19745-07-4]2,5-dichloropyrazine</strong> (217 mg, 1.46 mmol), tert-butyl ((3S,4S)-3- hydroxypiperidin-4-yl)carbamate (300 mg, 1.387 mmol) and K2CO3 (575 mg, 2.25 mmol) in DMSO (2.3 mL) was stirred at 90 °C for 12 h, then at room temperature overnight. The reaction was diluted with water (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL), dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo. The crude was purified by silica chromatography (0-15percent MeOH/DCM) followed by reverse phase chromatography (0 to 98percent MeCN/water). The fractions containing product were combined, concentrated to remove most ACN, diluted with sat. NaHCCb (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL) and dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (180.7 mg, 40percent yield). MS (apci) m/z = 329.2 (M+H).
 

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