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[ CAS No. 729-17-9 ] {[proInfo.proName]}

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Chemical Structure| 729-17-9
Chemical Structure| 729-17-9
Structure of 729-17-9 * Storage: {[proInfo.prStorage]}
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CAS No. :729-17-9 MDL No. :MFCD01122234
Formula : C15H14O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 242.27 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 729-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 729-17-9 ]
  • Downstream synthetic route of [ 729-17-9 ]

[ 729-17-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 729-17-9 ]
  • [ 725-14-4 ]
YieldReaction ConditionsOperation in experiment
98%
Stage #1: With sodium hydroxide; water In tetrahydrofuran at 20℃; for 16.5 h; Heating / reflux
Stage #2: With hydrogenchloride In tetrahydrofuran; water
[0158] Step 2 : 4 -METHOXY-BIPHENYL-4-CARBOXYLIC acid. 1 N NAOH (148.5 mL, 148. 5 mmol) was added under nitrogen to a solution of 4 -METHOXY-BIPHENYL-4-CARBOXYLIC acid methyl ester (12. 0G, 49.5 mmol), prepared in the previous step, in 1 L of THF plus 250 ML of water at room temperature. After the addition the reaction was refluxed for 16.5 h (overnight). After cooling to approximately room temperature the reaction was acidified by the addition of 1 N HC1 and then concentrated under reduced pressure. The solid that formed was collected by filtration and dried under reduced pressure to give 4 -METHOXY-BIPHENYL-4-CARBOXYLIC acid (11. 11 G, 98percent) as a white solid, mp 245-250°C ; MS (ESI) M/Z 227 [M-H]-. Elemental Analysis for C14H1203 : Calc'd: C, 73.67 ; H, 5.30 ; N, 0.00 ; Found: C, 69.52 ; H, 5.01 ; N, 0.04.
Reference: [1] Patent: WO2005/30702, 2005, A1, . Location in patent: Page/Page column 60
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984, # 1, p. 35 - 38
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 7, p. 3732 - 3743
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