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Chemical Structure| 7294-50-0 Chemical Structure| 7294-50-0

Structure of 7294-50-0

Chemical Structure| 7294-50-0

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Product Details of [ 7294-50-0 ]

CAS No. :7294-50-0
Formula : C21H21B3O3
M.W : 353.82
SMILES Code : CC1=CC=CC=C1B2OB(C3=CC=CC=C3C)OB(C4=CC=CC=C4C)O2

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Application In Synthesis of [ 7294-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7294-50-0 ]

[ 7294-50-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7294-50-0 ]
  • [ 22651-87-2 ]
  • [ 3277-78-9 ]
YieldReaction ConditionsOperation in experiment
50% With copper(l) iodide; palladium(II) trifluoroacetate; triphenyl-arsane; norbornene; potassium carbonate; p-benzoquinone; In toluene; at 100℃; for 14h;Sealed tube; Molecular sieve; General procedure: A flame-dried 4.0 mL vial was charged with Pd(TFA)2 (9.9 mg, 0.03 mmol, 10 mol%), benzoquinone (3.3mg, 0.03 mmol, 10 mol%), CuI (17.1 mg, 0.09 mmol, 30 mol%), AsPh3 (27.6 mg, 0.09 mmol, 30 mol%),arylboroxine (0.3 mmol, 1.0 equiv, based on monomer) and substituted benzoic anhydride (0.6 mmol, 2.0equiv). The vial was directly transferred into a nitrogen-filled glovebox without caps. Then, K2CO3 (6.2 mg,0.045 mmol, 15 mol%) and 4Å molecular sieves (400 mg) were added. In another 4.0 mL vial, NBE (16.9mg, 0.18 mmol) was dissolved in 1.5 mL dry toluene. 0.5 mL of this NBE solution (5.64 mg, 0.06 mmol, 20mol%) was transferred into the reaction mixture, before another 3.5 mL dry toluene was added. The vialwas tightly sealed, transferred out of glovebox and stirred on a pie-block preheated to 100 oC for 14 hours.After completion of the reaction, the mixture was filtered through a thin pad of silica gel. The filter cakewas washed with ethyl acetate and the combined filtrate was concentrated. The residue was loaded to asmall amount of silica gel and then purified by flash column chromatography on silica gel to give thedesired ortho acylation product.
 

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