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Chemical Structure| 736111-77-6 Chemical Structure| 736111-77-6

Structure of 736111-77-6

Chemical Structure| 736111-77-6

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Product Details of [ 736111-77-6 ]

CAS No. :736111-77-6
Formula : C9H15NO2
M.W : 169.22
SMILES Code : O=C([C@H]1NC2CCC1CC2)OC

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Application In Synthesis of [ 736111-77-6 ]

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  • Downstream synthetic route of [ 736111-77-6 ]

[ 736111-77-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109583-12-2 ]
  • [ 18107-18-1 ]
  • [ 736111-77-6 ]
YieldReaction ConditionsOperation in experiment
83.4% With methanol; In hexane; benzene; at 0 - 25℃; for 2.0h; e) 2-Aza-bicyclo[2.2.2]octane-(35)-carboxylic acid methyl ester[00238] 2-Aza-bicyclo[2.2.2]octane-(3S)-carboxylic acid (1.10 g, 7.09 mmol) was suspended in benzene (30 mL) and methanol (10 mL) and the mixture was cooled to 0 0C. A 2.0 M solution of (trimethylsilyl)diazomethane in hexanes (4.25 mL, 8.5 mmol) was added and the reaction was stirred at 0 0C for 1 h and then at 25 0C for 1 h. The mixture was concentrated in vacuo to afford the crude product, 2- aza-bicyclo[2.2.2]octane-(35)-carboxylic acid methyl ester (1.0 g, 5.91 mmol, 83.4% crude), as a solid, which was used directly in the next step without further purification. LC-MS (ESI) calcd for C9H15NO2 169.11, found 170.1 [M+H+].
 

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