* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 744 - 755
2
[ 110-85-0 ]
[ 446-52-6 ]
[ 736991-52-9 ]
Yield
Reaction Conditions
Operation in experiment
49.4%
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6 h; Inert atmosphere
50 ml round-bottom flask by adding 55A (1.0g, 8 . 1mmol), N, N-dimethylformamide (15 ml) to dissolve, then adding piperazine (836 mg, 9 . 7mmol) and K2CO3(1.68g, 12 . 2mmol), 130 °C reaction under 6h. After cooling to room temperature, diluted with water, ethyl acetate extraction, the combined organic phase dried with anhydrous sodium sulfate, concentrated after the silica gel column chromatography (petroleum ether: ethyl acetate = 5:1; dichloromethane: methanol =10:1) separation to obtain compound 55B (760 mg, yield 49.4percent).
Reference:
[1] Patent: CN105777632, 2016, A, . Location in patent: Paragraph 0481; 0482; 0483
3
[ 174855-57-3 ]
[ 736991-52-9 ]
Reference:
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 17, p. 4417 - 4423
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5605 - 5609
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6821 - 6830
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 20, p. 4615 - 4618
4
[ 111373-03-6 ]
[ 736991-52-9 ]
Reference:
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 744 - 755