[ CAS No. 741683-19-2 ]

Name: 741683-19-2|3-Chloro-2-fluoroisonicotinic acid|97%
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Quality Control of [ 741683-19-2 ]

COA NMR CNMR HPLC LC-MS

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SDS

Alternatived Products of [ 741683-19-2 ]

Product Details of [ 741683-19-2 ]

CAS No. :	741683-19-2	MDL No. :	MFCD09031169
Formula :	C₆H₃ClFNO₂	Boiling Point :	404.1°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	175.54 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 741683-19-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 741683-19-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 741683-19-2 ]

[ 741683-19-2 ] Synthesis Path-Downstream 1~1

1
[ 1480-64-4 ]
[ 124-38-9 ]
[ 741683-19-2 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of diisopropylamine (97 ml) in THF (1200 ml), n butyl lithium (2.66M-hexane solution, 239 ml) was added at -78C. The reaction liquid was stirred for 30 minutes at said temperature, and into which a solution of the above compound (76.14 g) in THF (300 ml) was added dropwise, followed by an hour's stirring. Dry ice was added to the reaction liquid, and after the temperature of the system was raised to the ambient level, the reaction mixture was poured into water and condensed under reduced pressure. The residue was extracted with ether. Hydrochloric acid was added to the aqueous phase to adjust the latter's pH to 2, followed by extraction with ethyl acetate. The organic layer was combined with the extract and washed with saturated brine, dried over anhydrous magnesium sulfate and condensed under reduced pressure. The residue was recrystallized from ether-hexane to provide 3-chloro-2-fluoroisonicotinic acid (55.9 g).
		In a nitrogen atmosphere, 97 mL of diisopropylamine was dissolved in 1.2 L of tetrahydrofuran, and at -70C, 239 mL of 2.66 M n-butyllithium-hexane solution was dropwise added thereto. The solution was stirred for 30 minutes, and then tetrahydrofuran (300 mL) solution of 76.14 g of the compound obtained in the above 1 was dropwise added thereto at -70C. This was stirred for 1 hour, and dry ice was added to the reaction solution, heated up to room temperature, and 1 L of water and diethyl ether were added thereto. Its pH was controlled to 10 with aqueous 4 M sodium hydroxide solution added to it. Then, its pH was controlled to 1 to 2 with concentrated hydrochloric acid added to it, and this was extracted three times with diethyl ether. The organic layers were combined, washed with saturated saline water, and dried with sodium sulfate. The solvent was evaporated off under reduced pressure, the residue was crystallized from ether-hexane to obtain 55.9 g of the entitled compound as a pale yellow solid.

Reference： [1]Patent: EP1595867,2005,A1 .Location in patent: Page/Page column 34
[2]Patent: EP1726590,2006,A1 .Location in patent: Page/Page column 56-57

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Ghs Precautionary Statements

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P220	Keep/Store away from clothing/combustible materials.
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P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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P240	Ground/bond container and receiving equipment.
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P242	Use only non-sparking tools.
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P262	Do not get in eyes, on skin, or on clothing.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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P501	Dispose of contents/container to ...
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
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H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
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H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 741683-19-2 ]

Quality Control of [ 741683-19-2 ]

Related Doc. of [ 741683-19-2 ]

Product Details of [ 741683-19-2 ]

Safety of [ 741683-19-2 ]

Application In Synthesis of [ 741683-19-2 ]

[ 741683-19-2 ] Synthesis Path-Downstream 1~1

Related Functional Groups of [ 741683-19-2 ]

Fluorinated Building Blocks

Chlorides

Carboxylic Acids

Related Parent Nucleus of [ 741683-19-2 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 741683-19-2 ]

Related Parent Nucleus of
[ 741683-19-2 ]