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[ CAS No. 741683-19-2 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 741683-19-2
Chemical Structure| 741683-19-2
Chemical Structure| 741683-19-2
Structure of 741683-19-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 741683-19-2 ]

CAS No. :741683-19-2 MDL No. :MFCD09031169
Formula : C6H3ClFNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :PYLURACOOBPBPM-UHFFFAOYSA-N
M.W :175.54 Pubchem ID :12175428
Synonyms :

Safety of [ 741683-19-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 741683-19-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 741683-19-2 ]

[ 741683-19-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1480-64-4 ]
  • [ 124-38-9 ]
  • [ 741683-19-2 ]
YieldReaction ConditionsOperation in experiment
To a solution of diisopropylamine (97 ml) in THF (1200 ml), n butyl lithium (2.66M-hexane solution, 239 ml) was added at -78C. The reaction liquid was stirred for 30 minutes at said temperature, and into which a solution of the above compound (76.14 g) in THF (300 ml) was added dropwise, followed by an hour's stirring. Dry ice was added to the reaction liquid, and after the temperature of the system was raised to the ambient level, the reaction mixture was poured into water and condensed under reduced pressure. The residue was extracted with ether. Hydrochloric acid was added to the aqueous phase to adjust the latter's pH to 2, followed by extraction with ethyl acetate. The organic layer was combined with the extract and washed with saturated brine, dried over anhydrous magnesium sulfate and condensed under reduced pressure. The residue was recrystallized from ether-hexane to provide 3-chloro-2-fluoroisonicotinic acid (55.9 g).
In a nitrogen atmosphere, 97 mL of diisopropylamine was dissolved in 1.2 L of tetrahydrofuran, and at -70C, 239 mL of 2.66 M n-butyllithium-hexane solution was dropwise added thereto. The solution was stirred for 30 minutes, and then tetrahydrofuran (300 mL) solution of 76.14 g of the compound obtained in the above 1 was dropwise added thereto at -70C. This was stirred for 1 hour, and dry ice was added to the reaction solution, heated up to room temperature, and 1 L of water and diethyl ether were added thereto. Its pH was controlled to 10 with aqueous 4 M sodium hydroxide solution added to it. Then, its pH was controlled to 1 to 2 with concentrated hydrochloric acid added to it, and this was extracted three times with diethyl ether. The organic layers were combined, washed with saturated saline water, and dried with sodium sulfate. The solvent was evaporated off under reduced pressure, the residue was crystallized from ether-hexane to obtain 55.9 g of the entitled compound as a pale yellow solid.
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