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Chemical Structure| 74289-57-9 Chemical Structure| 74289-57-9

Structure of 74289-57-9

Chemical Structure| 74289-57-9

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Product Details of [ 74289-57-9 ]

CAS No. :74289-57-9
Formula : C16H18ClP
M.W : 276.74
SMILES Code : ClP(C1=CC(C)=CC(C)=C1)C2=CC(C)=CC(C)=C2
MDL No. :MFCD01630841
InChI Key :FCEBDAANWYNQMO-UHFFFAOYSA-N
Pubchem ID :4187520

Safety of [ 74289-57-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 74289-57-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74289-57-9 ]

[ 74289-57-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 83004-13-1 ]
  • [ 74289-57-9 ]
  • [ 1283601-75-1 ]
YieldReaction ConditionsOperation in experiment
33% 2-Bromo-6-ethylpyridine (18.2 mmol) was dissolved in 40 ml of tetrahydrofuran [THF], and 1.65 M hexane solution of n-butyllithium (19.1 mmol) was added dropwise thereto with cooling with dry ice-ethanol bath and with stirring.Then, the mixed liquid obtained was stirred for 10 minutes to obtain a reaction mixture.To the reaction mixture obtained, chlorobis (3,5-dimethylphenyl) phosphide (16.8 mmol) dissolved in 20 ml of THF was added, and the temperature was brought back to room temperature and the stirring was carried out under room temperature for 3 hours to conduct the reaction.To the solution obtained, a little amount of water was added to quench the reaction, and a saturated aqueous sodium chloride solution was further added thereto.Next, to the solution obtained, ethyl acetate was added to stir and separate, and then, an ethyl acetate phase (an organic phase) was collected by separation.This organic layer was dried over anhydrous magnesium sulfate, and filtrated, and the filtrate obtained was concentrated under reduced pressure.The concentrate obtained was purified twice with silica gel chromatography (developer: hexane/ethyl acetate = 20/1) to obtain 2.07 g of bis(3,5-dimethylphenyl)(6-ethyl-2-pyridyl)phosphine (Yield 33percent).The purity calculated with 1H-NMR analysis was 97percent.1H-NMR (CDCl3, 600 MHz) : 5 7.44 (td, 1H, J=8.2 Hz), 7.03-6.95 (m, 7H), 7.03 (d, 1H, J=8 Hz), 6.83 (d, 1H, J=8 Hz), 2.83 (q, 2H, J=8 Hz), 2.26 (s, 12H), 1.27 (t, 3H, J= 8Hz)
  • 2
  • [ 1293-65-8 ]
  • [ 74289-57-9 ]
  • C26H25Br2FeOP [ No CAS ]
 

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