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Chemical Structure| 7461-11-2 Chemical Structure| 7461-11-2

Structure of 7461-11-2

Chemical Structure| 7461-11-2

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Product Details of [ 7461-11-2 ]

CAS No. :7461-11-2
Formula : C9H7ClN2
M.W : 178.62
SMILES Code : NC1=C2N=C(Cl)C=CC2=CC=C1
MDL No. :MFCD15147049

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Application In Synthesis of [ 7461-11-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7461-11-2 ]

[ 7461-11-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3973-08-8 ]
  • [ 7461-11-2 ]
  • N-(2-chloroquinolin-8-yl)thiazole-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
194 mg With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; Step 2) Preparation of N-(2-chloroquinolin-8-yl)thiazole-4-carboxamide: A solution of 2-chloroquinolin-8-amine (222 mg), thiazole-4-carboxylic acid (129 mg, 1eq), HATU (570 mg, 1.5 eq), and DIEA (246 uL, 2.0 eq) in DMF (3 mL) was stirred at room temperature overnight. The product was precipitated by the addition of water (20 mL), the product was collected by filtration and recrystallized from methanol to obtain the product as a grey solid (194 mg). The following material was prepared in a similar fashion:
 

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