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Chemical Structure| 749875-16-9 Chemical Structure| 749875-16-9

Structure of 749875-16-9

Chemical Structure| 749875-16-9

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Product Details of [ 749875-16-9 ]

CAS No. :749875-16-9
Formula : C7H3BrF3NO2
M.W : 270.00
SMILES Code : O=C(O)C1=C(Br)C=NC(C(F)(F)F)=C1
MDL No. :MFCD10687236
InChI Key :XNVAVQMVAYUTBA-UHFFFAOYSA-N
Pubchem ID :28306936

Safety of [ 749875-16-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 749875-16-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 749875-16-9 ]

[ 749875-16-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 518057-72-2 ]
  • [ 749875-16-9 ]
  • 5-bromo-N-(3-carbamoyl-4-fluorophenyl)-2-(trifluoromethyl)pyridine-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In Isopropyl acetate; at 20℃; for 1h; 5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid (107 mg, 0.40 mmol), 5-amino-2- fluoro-benzamide (71 mg, 0.46 mmol), triethylamine (350 mu, 2.51 mmol) and 2,4,6-tripropyl- 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (800 mu^ of 50 %w/v, 1.26 mmol) in isopropyl acetate (2 mL) was stirred at room temperature for 1 hour. The mixture was concentrated in vacuo and the residue was partitioned between DCM and saturated aqueous sodium bicarbonate. Layers were separated and the organic layer dried over magnesium sulfate, filtered and concentrated in vacuo to afford 5-bromo-N-(3- carbamoyl-4-fluoro-phenyl)-2-(trifluoromethyl)pyridine-4-carboxamide ( 161 mg, 100%) as a colourless oil. ESI-MS m/z calc. 404.97, found 408.1 (M+l)+; Retention time (Method F): 0.74 minutes ( 1.5 minutes run).
  • 2
  • [ 518057-72-2 ]
  • [ 749875-16-9 ]
  • N-(3-carbamoyl-4-fluorophenyl)-5-(4-fluoro-2-methoxyphenyl)-2-(trifluoromethyl)pyridine-4-carboxamide [ No CAS ]
 

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