Alternatived Products of [ 7560-43-2 ]
Product Details of [ 7560-43-2 ]
CAS No. : | 7560-43-2 |
MDL No. : | MFCD00460746 |
Formula : |
C11H12O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | WLJBRXRCJNSDHT-BQYQJAHWSA-N |
M.W : |
176.21
|
Pubchem ID : | 5314312 |
Synonyms : |
|
Application In Synthesis of [ 7560-43-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 7560-43-2 ]
- Downstream synthetic route of [ 7560-43-2 ]
- 1
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[ 7560-43-2 ]
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[ 946-99-6 ]
Yield | Reaction Conditions | Operation in experiment |
99.5% |
|
1) Under argon protection,Methyl p-methylcinnamate,Mix the auxiliary with 1,2-dichloroethane,Control the reaction temperature to 120 C,Pressure to 5 atmospheres,After stirring for 1.5 hours,Maintain reaction conditions,A mixed aqueous solution of tetrabutylammonium bromide and glacial acetic acid was added dropwise to control the dropwise addition time to 2 h, and after the completion of the dropwise addition, the temperature was controlled to 150 C.The pressure is up to 8 atmospheres and the reaction ends at 5h.The molar ratio of methyl methyl cinnamate, tetrabutylammonium bromide and glacial acetic acid is 1:0.82:1.6; the concentration of tetrabutylammonium bromide in the mixed aqueous solution is 20% by mass; The ratio of ester to 1,2-dichloroethane was 1 g: 5.2 mL.The auxiliary material is prepared by grinding diatomaceous earth to 250 mesh, adding to a mixture of potassium bromate aqueous solution and toluene, heating to reflux and separating water, removing water, evaporating the remaining toluene, and uniformly grinding the obtained solid. Obtained at 260 C for 2.5 h; the mass ratio of diatomaceous earth to potassium bromate aqueous solution is 1:3.2; the volume ratio of potassium bromate aqueous solution to toluene is 1:4.5; the concentration of potassium bromate aqueous solution is 18% by mass; p-methylcinnamic acid The molar ratio of the methyl ester to the potassium bromate in the auxiliary is 1: (0.25 to 0.28).2) After cooling the system, pour into 3 volumes of water, add dichlorohexane to extract, and the ratio of methyl methyl cinnamate to dichloromethane is 1g: 4.5mL; after extraction, layering, organic layer After washing with water and drying over anhydrous sodium sulfate, the solvent was concentrated by evaporation on a rotary evaporator to give the product. The molar yield was 99.5% and the GC purity was 99.3%. |
- 2
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[ 6443-85-2 ]
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[ 7560-43-2 ]
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threo-methyl 4-cyano-4-(pyridin-3-yl)-3-(4-methylphenyl)butanoate
[ No CAS ]
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erythro-methyl 4-cyano-4-(pyridin-3-yl)-3-(4-methylphenyl)butanoate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
16%; 19% |
With sodium methylate; In methanol; at 50℃; for 24h;Inert atmosphere; |
0724] Under protective gas (Ar), 0.1 ml of 30% strength methanolic sodium methoxide solution was added to 1.200 g (6.810 mmol) of methyl 3-(4-methylphenyl)acrylate and 0.805 g (6.810 mmol) of pyridin-3-ylacetonitrile in 6.0 ml of methanol, and the mixture was stirred at 50 C. for 24 h. The reaction mixture was poured into ice-water and extracted three times with ethyl acetate, and the combined organic phases were dried over sodium sulphate. The solvent was removed under reduced pressure. Chromatography of the residue on silica gel (ethyl acetate/heptane=85:15) gave, successively, 0.361 g (16% of theory) of threo-methyl 4-cyano-4-(pyridin-3-yl)-3-(4-methylphenyl)butanoate and 0.427 g (19% of theory) of erythro-methyl 4-cyano-4-(pyridin-3-yl)-3-(4-methylphenyl)butanoate. The configuration was assigned by comparison of the chemical shifts of the respective CHCN doublets at 4.13 ppm and 4.44 ppm, respectively, in the 1H-NMR (CDCl3). The lower-field signal was assigned to the erythro-diastereomer, analogously to the literature. 1H-NMR in CDCl3 see Table 2. |