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Chemical Structure| 75772-01-9 Chemical Structure| 75772-01-9

Structure of 75772-01-9

Chemical Structure| 75772-01-9

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Product Details of [ 75772-01-9 ]

CAS No. :75772-01-9
Formula : C26H24ClOP
M.W : 418.89
SMILES Code : C1([P+](C2=CC=CC=C2)(COCC3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1.[Cl-]
MDL No. :MFCD00134180
InChI Key :GJPGLLAXZTYTFW-UHFFFAOYSA-M
Pubchem ID :11452854

Safety of [ 75772-01-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 75772-01-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75772-01-9 ]

[ 75772-01-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75772-01-9 ]
  • [ 7126-57-0 ]
  • ethyl 4-[(E)-2-(benzyloxy)ethenyl]-1H-pyrrole-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% The suspension of[(benzyloxy)methyl](triphenyl)phosphonium chloride (52, 9.00 g, 21.5 mmol) in dry THF (100 mL) wasstirred and cooled to -78 C, then butyllithium solution was added dropwise (7.75 mL, 19.4 mmol), andstirred at -78 C for 30 min. To this solution, <strong>[7126-57-0]ethyl 4-formyl-1H-pyrrole-2-carboxylate</strong> (53, 0.90 g, 5.38 mmol)dissolved in dry THF (10 mL) was added dropwise and the reaction was warmed to RT and stirred for 16h. The organic layer was washed with water, dried over MgSO4, filtered and purified by flashchromatography in hexane-ethyl acetate to give ethyl 4-[(E)-2-(benzyloxy)ethenyl]-1H-pyrrole-2-carboxylate (54, 0.80 g, 2.95 mmol, 55% yield). LC-MS [M+H]+: 272 m/z. 1H-NMR (500 MHz, CDCl3) δ 9.15(s, 1H), 7.37 (m, 4H), 7.22 (d, J = 1.1 Hz, 1H), 7.03 (s, 1H), 6.17 (t, J = 5.9 Hz, 1H), 5.27 (d, J = 6.5 Hz, 1H), 4.97(s, 2H), 4.32 (q, J = 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H).
 

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