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Chemical Structure| 759-65-9 Chemical Structure| 759-65-9
Chemical Structure| 759-65-9

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Methyloxalacetic acid diethyl ester is a member of the class of compounds known as beta-keto acids and derivatives.

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Product Details of Diethyl oxalpropionate

CAS No. :759-65-9
Formula : C9H14O5
M.W : 202.20
SMILES Code : O=C(OCC)C(C)C(C(OCC)=O)=O
MDL No. :MFCD00009163
InChI Key :OQOCQBJWOCRPQY-UHFFFAOYSA-N
Pubchem ID :97750

Safety of Diethyl oxalpropionate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Diethyl oxalpropionate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 759-65-9 ]

[ 759-65-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 759-65-9 ]
  • [ 38980-96-0 ]
  • [ 1240313-23-8 ]
  • [ 1240313-25-0 ]
YieldReaction ConditionsOperation in experiment
With sodium ethanolate; In ethanol; at 20℃; for 18h; A suspension of sodium ethoxide (940 mg, 13.8 mmol) in ethanol (4.5 ml) was added to a solution of <strong>[38980-96-0]4-(trifluoromethyl)benzamidine hydrochloride</strong> dihydrate (2.79 g, 12.4 mmol) and diethyl oxalpropiolate (2.6 ml, 13.8 mmol) in ethanol (30ml) and the resulting mixture stirred at ambient temperature for 18 hours. The reaction mixture was concentrated under reduced pressure, then dichloromethane was added and the solution dried over magnesium sulphate, filtered and evaporated under redcued pressure. The crude product was purified by chromatography on silica using hexane/ethyl acetate (3:2) as eluent to provide a mixture of 6-ethoxycarbonyl-4-hydroxy- 5-methyl-2-(4-trifluoromethylphenyl)-pyrimidine and 4,6-dihydroxy-6-ethoxycarbonyl-5- methyl-2-(4-trifluoromethylphenyl)-3,4-dihydropyrimidine as a pale brown solid (2.21 g).
 

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