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Chemical Structure| 761440-65-7 Chemical Structure| 761440-65-7

Structure of 761440-65-7

Chemical Structure| 761440-65-7

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Product Details of [ 761440-65-7 ]

CAS No. :761440-65-7
Formula : C17H26N4O3
M.W : 334.41
SMILES Code : CN1CCN(C2CCN(C3=CC=C([N+]([O-])=O)C(OC)=C3)CC2)CC1
MDL No. :MFCD18072517

Safety of [ 761440-65-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 761440-65-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 761440-65-7 ]

[ 761440-65-7 ] Synthesis Path-Downstream   1~2

  • 2
  • 2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine [ No CAS ]
  • [ 761440-65-7 ]
  • [ 1097917-15-1 ]
YieldReaction ConditionsOperation in experiment
50.1% Step 5 Synthesis of N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (the compound of Formula (1)) To a mixture of 2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (the compound of Formula (13), 29.2 g) and ethanol (450 mL), methanesulfonic acid (19.0 mL) was added, and the resulting mixture was stirred at room temperature for 15 minutes. Subsequently, 4-chloro-N-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazin-2-amine (the compound of Formula (14), 30.0 g) was added thereto, followed by stirring at 100C for 5 hours. After the reaction mixture was allowed to cool, diethyl ether (900 mL) was added thereto and a precipitated solid was collected by filtration. The obtained solid was dissolved in water (300 mL) and adjusted to pH8 with a saturated aqueous sodium hydrogen carbonate solution, and then the resulting mixture was extracted three times with ethyl acetate (300 mL). After an organic layer obtained was washed with water and saturated brine and then dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; chloroform:methanol:saturated aqueous ammonia = 100:1:0 to 20:1:0.1) and then washed with ethanol to give N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (27.9 g, 50.1% yield) as a pale beige solid.
 

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