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Chemical Structure| 774-74-3 Chemical Structure| 774-74-3

Structure of 774-74-3

Chemical Structure| 774-74-3

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Product Details of [ 774-74-3 ]

CAS No. :774-74-3
Formula : C8H5Cl3O2
M.W : 239.48
SMILES Code : O=C(Cl)COC1=CC=C(Cl)C=C1Cl
MDL No. :MFCD00045225
InChI Key :FUJSJWRORKKPAI-UHFFFAOYSA-N
Pubchem ID :69887

Safety of [ 774-74-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H314-H332
Precautionary Statements:P260-P261-P264-P270-P271-P280-P301+P312-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P321-P322-P330-P363-P405-P501
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 774-74-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 774-74-3 ]

[ 774-74-3 ] Synthesis Path-Downstream   1~3

  • 3
  • [ 774-74-3 ]
  • [ 120068-37-3 ]
  • [ 927435-33-4 ]
YieldReaction ConditionsOperation in experiment
73.5% With dmap; triethylamine; In 1,2-dichloro-ethane; at 0℃; for 8h;Reflux; With magnetic stirring,In a 50 mL three-neck flask containing a thermometer and a constant pressure funnel, add 4.8 mmol of <strong>[120068-37-3]fipronil</strong> [Chemical name:5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole-3-carboxamide],20m dry 1,2-dichloroethane (DCE), ice bath below 0C,0.5 mmol of 4-dimethylaminopyridine (DMAP) and 6.5 mmol of triethylamine are added, and a solution of the acid chloride in 5 ml of 1,2-dichloroethane is added dropwise. The ice bath is withdrawn and the temperature is slowly raised to reflux.Reaction for 8 hours,Cool to room temperatureWash twice with 1% dilute hydrochloric acid and rinse twice.The organic phase is dried over anhydrous sodium sulfate and dissolved.Column chromatography with petroleum ether and ethyl acetate (5:1 by volume) gave a white solid with the structural formula I-41N-[3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)4-trifluoromethylsulfinyl-1H-pyrazol-5-yl]-2-(2,4-dichlorophenoxy)acetamide2.26 g. The yield based on <strong>[120068-37-3]fipronil</strong> was 73.5%.
 

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