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Chemical Structure| 775302-21-1 Chemical Structure| 775302-21-1

Structure of 775302-21-1

Chemical Structure| 775302-21-1

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Product Details of [ 775302-21-1 ]

CAS No. :775302-21-1
Formula : C15H13N3O
M.W : 251.28
SMILES Code : NC1=CC=CC(C2=NN=C(C3=CC=C(C)C=C3)O2)=C1
MDL No. :MFCD06760278

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Application In Synthesis of [ 775302-21-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 775302-21-1 ]

[ 775302-21-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20291-40-1 ]
  • [ 775302-21-1 ]
  • [ 1620517-26-1 ]
YieldReaction ConditionsOperation in experiment
61% With 3-Methylpyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 24h; In an ice-water bath, to a mixture of 8 (0.25g, 1mmol), EDC (0.4g), HOBt (0.3g) and monomethyl heptanedioate (17b, 0.15g) in DCM (10mL) was added 3-picoline (0.3mL), and after stirring for 24h, the reaction solution was diluted by DCM (20mL) and methanol (8mL). The organic solution was washed by 5% HCl, 5% NaOH and saturated NaHCO3 successively, dried over anhydrous Na2SO4, and then purified by column chromatography (DCM/EtOAc=10/1) to give 17a as a white solid (0.25g, yield: 61%). 17a was reduced by NaBH4 by a procedure similar to that for the preparation of 14 to give 17 as a white solid.
 

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